Measurement model for respiratory-swallowing impairment

描述(申请人提供)：阻塞性呼吸道疾病是复杂的，涉及多个身体系统，有很高的发病率，并在年龄连续的极端脆弱患者中流行。我们认为，对吞咽的作用，特别是呼吸-吞咽协调的调查非常适合这项规划拨款的目标和目的，针对多个地点和多学科合作。具体目标是基于这样一个工作前提，即患有阻塞性呼吸道疾病的儿童和成人患者存在协调呼吸-吞咽功能问题，可能会加速和/或加剧肺部症状和状况。我们的协作团队将通过共识验证过程确定综合呼吸和吞咽功能优化研究所需的关键组件和措施并确定其优先顺序。具体目标1.召集一个多学科、协作的研究团队，他们在呼吸和吞咽协调、呼吸道异常和阻塞性呼吸道疾病方面拥有既定的、专注的专业知识。2.根据抽吸的风险模型和潜在发现的临床相关性，对需要立即研究的儿童和成人阻塞性呼吸道疾病的亚组进行优先排序和分层。3.获得标准化评估方案和多指标方法的共识验证，以量化呼吸和吞咽损害的严重程度(S)，并将这些潜在相关损害对患有上下呼吸道阻塞障碍的婴儿、儿童和老年人的临床结果的贡献联系起来。4.获得对捕捉总体患者结果的功能和健康状况衡量标准的共识验证。5.开发一项多点临床研究(R01)，测试呼吸吞咽测量模型与测量的可靠性和结构效度的评估，以及它们与患者预后的关系。

DESCRIPTION (provided by applicant): Obstructive airway disorders are complex, involve multiple body systems, have high morbidity, and are prevalent in fragile patients at the extremes of the age continuum. We believe that an investigation of the role of swallowing and, in particular, respiratory-swallowing coordination is ideally suited for the goals and objectives of this planning grant, targeting multiple sites and multidisciplinary collaboration. The Specific Aims are based on the working premise that pediatric and adult patients with obstructive airway disorders suffer from problems with coordinative respiratory-swallowing function that may accelerate and/or exacerbate the pulmonary symptoms and condition. The critical components and measures required for optimal study of integrated respiratory and swallowing function will be identified and prioritized by our collaborative team through a consensus validation process. Specific Aim 1. Convene a multidisciplinary, collaborative team of researchers with established, focused expertise in respiratory and swallowing coordination, airway abnormalities, and obstructive airway disorders. 2. Prioritize and stratify the subgroups of pediatric and adult obstructive airway disorders that warrant immediate study based on an at-risk model for aspiration and clinical relevance of the potential findings. 3. Obtain consensus validation for a standardized evaluation protocol and multi-metric approach to quantify the severity of respiratory and swallowing impairment(s) and to relate the contribution of these potentially- linked impairments to the clinical outcomes of infants, children, and aging adults with upper and lower obstructive airway disorder. 4. Obtain consensus validation for the functional and health status measures that capture the overall patient outcome. 5. Develop a multi-site clinical study (R01) that tests the respiratory-swallowing measurement model vis-a- vis assessment of reliability and construct validity of the measures, and their relationship to patient outcomes.