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Respiratory-Swallow Training in Veterans with Oropharyngeal Cancer

患有口咽癌的退伍军人的呼吸吞咽训练

基本信息

批准号：
8466756
负责人：
BONNIE J MARTIN-HARRIS
金额：
--
依托单位：
RALPH H JOHNSON VA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-03-01 至 2013-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8466756
关键词：
Ablation Acute Barium swallow Bolus Infusion Breathing Cancer Patient Characteristics Chronic Clinical Clinical Trials Coupled Data Deglutition Deglutition Disorders Diet Modification Disease Eating Feedback Generations Goals Head and Neck Cancer Head and neck structure Health Health system Impairment Individual Intake Intention Intervention Larynx Learning Life Link Liquid substance Literature Longevity Lung diseases Measurable Measures Mechanics Methods Modification Morbidity - disease rate Motor Multi-Institutional Clinical Trial Nature Operative Surgical Procedures Oral Organ Preservation Oropharyngeal Outcome Outcome Measure Patients Pattern Penetration Pharyngeal structure Phase Physiological Population Posture Prevention Protocols documentation Quality of life Radiation Recording of previous events Recovery Recovery of Function Regimen Rehabilitation therapy Research Resistance Respiration Respiration Disorders Respiratory System Risk Safety Series Severities Stroke Testing Therapeutic procedure Toxic effect Training Veterans abstracting chemotherapy cohort cost design drinking evidence base exhaust experience improved malignant oropharynx neoplasm muscular structure novel novel therapeutics patient population pressure primary outcome research clinical testing respiratory standard of care treatment effect trial comparing

项目摘要

DESCRIPTION (provided by applicant): PROJECT SUMMARY/ABSTRACT Swallowing impairments (dysphagia) represent the highest functional morbidity in veteran patients treated for oropharyngeal cancers with either surgical approaches followed by radiation or with more recent organ-preservation protocols. The nature of the impairments is often resistive to treatment and results in life-long health consequences and high cost burden on the VA health system. Recent preliminary data have linked alterations in the otherwise highly stable respiratory-swallowing phase pattern relationships to the swallowing impairment and penetration/aspiration and in this patient group. The immediate goal of this clinical trial is to test the effect of a novel respiratory-swallow intervention on swallowing impairment and penetration/aspiration in a cohort of chronically dysphagic veterans following treatment for oropharyngeal cancer. Patients presenting with a "non-optimal" respiratory-swallow phase pattern during liquid swallows and measurable swallowing impairment will learn an "optimal" physiologic pattern that facilitates both airway protective and mechanical advantages during swallowing. The broad goal of this research is to develop ideal respiratory- swallowing phase training methods and regimens that alone or combined with traditional swallowing treatments improve swallowing function in the acute phases of recovery and improve long term patient outcome. Our intention is to use these preliminary data to motivate a larger clinical trial to compare the effect of respiratory-swallow phase training with other evidenced based methods of swallowing treatment and expand the approach to other patient groups that have indications of respiratory- swallow phase impairments (e.g. pulmonary disease and stroke) contributing to impaired swallowing function.

描述（由申请人提供）：