The South African Infectious Disease Clinical Research Training Program

描述（由申请人提供）：南非正面临世界上最严重的结核病流行之一，发病率是其他发展中国家的两倍多，比美国或西欧目前的发病率高出60倍。如果要改善这种情况，重点突出和可持续的临床研究至关重要，南非必须具备进行传染病大规模社区试验的能力。不幸的是，一个健全的临床研究风气不是在这个国家的事态。由不同的美国和国际赞助商支持的项目通过提供研究伦理课程，鼓励追求基础科学和/或公共卫生的研究生证书或高级学位，并提供执行诊断和分子生物学程序所需技术的专业培训来提供帮助。然而，这些培训主要面向高级研究人员，而且往往要求调查人员参加在其他国家举办的培训。临床研究团队的其他成员几乎没有正式的发展选择，这些人通常没有机会和资源来追求专业发展，无论是在国内还是在国际上。南非传染病临床研究培训方案的长期目标是在整个临床研究团队中建立可持续的传染病研究能力。为了实现这一目标，SAIDCRTP将1）在开普敦大学（UCT）内建立可持续的研究能力，2）在UCT创建临床研究管理硕士学位课程，3）为其他南非人提供临床研究能力建设。这项申请与南非公民的公共健康高度相关。通过实现其目标和目的，SAIDCRTP将加强南非人进行的良好临床研究的执行，并通过专业发展计划和高质量的学术硕士学位课程扩大临床研究的教育机会。

DESCRIPTION (provided by applicant): South Africa is facing one of the worst tuberculosis epidemics in the world, with disease rates more than double those observed in other developing countries, and up to 60 times higher than those currently seen in the USA or Western Europe. Focused and sustainable clinical research is critical if the situation is to improve, and South Africa must possess the capacity to conduct large community trials in infectious diseases. Unfortunately, a sound clinical research ethos is not the state of affairs in this country. Programs supported from different U.S. and international sponsors are assisting by providing courses in research ethics, encouraging the pursuit of graduate certificates or advanced degrees in the basic sciences and/or public health, and offering specialized training in the performance of techniques necessary to perform diagnostic and molecular biology procedures. However, these are mostly geared to senior researchers and often require investigators to attend training in other countries. Few formal development options are available for other members of the clinical research team, and these individuals usually have little opportunity and resources to pursue professional development, either in-country or at international offerings. The long-term goal of the South Africa Infectious Disease Clinical Research Training Program (SAIDCRTP) is to build sustainable research capacity in infectious diseases within the total clinical research team. To accomplish this, SAIDCRTP will 1) build sustainable research capacity within the University of Cape Town (UCT), 2) create a masters degree program in clinical research administration at UCT, and 3) offer capacity building in clinical research to other South Africans. This application is highly relevant to the public health of South African citizens. By accomplishing its goal and objectives, SAIDCRTP will enhance the execution of good clinical research performed by South Africans, and expand education opportunities in clinical research through a professional development program and a high-quality academic masters degree program.