COLUMBIA CENTER FOR CHILDRENS ENVIRONMENTAL HEALTH

哥伦比亚儿童环境健康中心

• 批准号: 6623230
• 负责人: FREDERICA P PERERA
• 金额: $ 81.4万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-11-01 至 2004-05-06
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6623230
• 关键词: clinical research; environmental toxicology

The aim of this study is to lower the risk of asthma in young African American and Hispanic children living in northern Manhattan through two interventions, one at the community level and one at the household level. For the Community Education Intervention (CEI) the Center and its community partners, coordinated by West Harlem Environmental Action, Inc (WE ACT) will join with other community based organizations, including Alianza Dominicana, to develop, implement, and evaluate a community wide intervention to increase awareness of environmental health hazards, particularly airborne pollutants and allergens, and educate community members to take action and events held throughout Northern Manhattan. The CEI will be delivered through a combination of written and audiovisual materials, and public meetings and events held throughout Northern Manhattan. The CEI will be evaluated with data from maternal questionnaires from the cohort of 400 mothers enrolled in the developmental studies (see Ford and Perera projects). Using a single group pre-test-post-test research design, we hypothesize that from baseline to follow-up 24 months later the CEI intervention will: 1.1 Reach 10% of the wp,em aged 18-35 living in Northern Manhattan; and 1.2 Increase the percentage pf wp,em aged 18-35 who take steps to prevent or reduce environmental hazards in their households or in the community. The household intervention will consist of an Indoor Pollution and Allergen Control childhood. When the cohort of 400 children research their second birthday, we will enroll the 120 children (30%) with the highest total IgE levels--the best predictor of asthma at any age--for a one year trial of environmental strategies to prevent asthma. Enrolled families will be randomly assigned to treatment or control studies, and we will intervene in treatment group households to (a) clean and seal the preparation that includes antioxidant vitamins A, C, and E and selenium (Se), and (c) provide the child's mother with written materials and one-to-one counseling by the health educator about the importance of and methods for reducing environmental tobacco smoke (ETS) in the home. Control group families will be given a placebo intervention that includes a multi- vitamin preparation for children that does not contain the anti-oxidant vitamins and written materials about reducing exposure to ETS. Baseline data will be collected at each child's second birthday (24 months) and follow up data will be collected at 30 months (household allergen levels) and 36 months (all measures). We hypothesize that from baseline to follow up the treatment group will have, relative to controls: 2.1 reduced plasma levels of cotinine in children; 2.2 reduced household levels of cockroach and dust mite allergen; 2.3 higher plasma levels of vitamins A, C, and E and Se in children; 2.4 lower sera levels of total, cockroach-specific, rodent-specific, and dust mite-specific IgE in children; 2.5 fewer clinical signs or symptoms of asthma or allergies in children.

这项研究的目的是降低非洲年轻人患哮喘的风险 居住在曼哈顿北部的美国和西班牙裔儿童通过两个 干预措施，一项在社区一级，一项在家庭一级。 对于社区教育干预（CEI），该中心及其 社区合作伙伴，由 West Harlem Environmental Action, Inc 协调 （WE ACT）将与其他社区组织合作，包括 Alianza Dominicana，开发、实施和评估整个社区 干预措施以提高对环境健康危害的认识， 特别是空气污染物和过敏原，并对社区进行教育 成员采取行动并在整个曼哈顿北部举办活动。这 CEI 将通过书面和视听相结合的方式进行 材料以及在整个北部举行的公共会议和活动 曼哈顿。 CEI 将根据产妇的数据进行评估 对 400 名母亲的调查问卷 发展研究（参见福特和佩雷拉项目）。使用单个组 测试前-测试后研究设计，我们假设从基线到 24 个月后的后续行动，CEI 干预将： 1.1 达到 10% wp,em 年龄 18-35 岁，居住在曼哈顿北部； 1.2 增加 18-35 岁的 WP、EM 采取措施预防或减少的百分比 家庭或社区中的环境危害。这 家庭干预将包括室内污染和过敏原 控制童年。当 400 名儿童研究他们的第二个 生日，我们将录取IgE总量最高的120名儿童（30%） 水平——任何年龄哮喘的最佳预测指标——为期一年的试验 预防哮喘的环境策略。已报名的家庭将 随机分配到治疗或对照研究，我们将进行干预 在治疗组家庭中 (a) 清洁并密封以下制剂： 包括抗氧化维生素 A、C 和 E 以及硒 (Se) 和 (c) 为孩子妈妈提供书面材料并一对一 健康教育者就其重要性和方法进行咨询 减少家中环境烟草烟雾 (ETS)。对照组 家庭将接受安慰剂干预，其中包括多种 不含抗氧化剂的儿童维生素制剂 有关减少接触 ETS 的维生素和书面材料。基线 数据将在每个孩子两周岁（24 个月）时收集，并且 后续数据将在 30 个月时收集（家庭过敏原水平） 和 36 个月（所有措施）。我们假设从基线到遵循 相对于对照组，治疗组将出现： 2.1 血浆减少 儿童的可替宁水平； 2.2 减少家庭蟑螂数量 和尘螨过敏原； 2.3 维生素A、C和E的血浆水平升高 儿童中的硒； 2.4 降低蟑螂特异性总血清水平， 儿童中啮齿动物特异性和尘螨特异性 IgE；减少2.5 儿童哮喘或过敏的临床体征或症状。

项目成果

Potential health benefits of sustained air quality improvements in New York City: A simulation based on air pollution levels during the COVID-19 shutdown.

纽约市空气质量持续改善的潜在健康益处：基于 COVID-19 关闭期间空气污染水平的模拟。

• DOI: 10.1016/j.envres.2020.110555
• 发表时间: 2021
• 期刊: Environmental research
• 影响因子: 8.3
• 作者: Perera,Frederica;Berberian,Alique;Cooley,David;Shenaut,Elizabeth;Olmstead,Hollie;Ross,Zev;Matte,Thomas
• 通讯作者: Matte,Thomas

Coronary heart disease, chronic inflammation, and pathogenic social hierarchy: a biological limit to possible reductions in morbidity and mortality.

冠心病、慢性炎症和致病的社会等级：发病率和死亡率可能降低的生物学限制。

• 发表时间: 2004
• 期刊: Journal of the National Medical Association
• 影响因子: 3.3
• 作者: Wallace,Rodrick;Wallace,Deborah;Wallace,RobertG
• 通讯作者: Wallace,RobertG

Prenatal exposure to air pollution is associated with altered brain structure, function, and metabolism in childhood.

• DOI: 10.1111/jcpp.13578
• 发表时间: 2022-02
• 期刊: Journal of child psychology and psychiatry, and allied disciplines
• 作者: Brad Peterson;R. Bansal;Siddhant Sawardekar;Carlo Nati;Eman R Elgabalawy;Lori A. Hoepner;Wanda E Garcia;Xuejun Hao;A. Margolis;F. Perera;V. Rauh

Adaptation, punctuation and information: a rate-distortion approach to non-cognitive 'learning plateaus' in evolutionary process.

适应、标点符号和信息：进化过程中非认知“学习高原”的速率扭曲方法。

• DOI: 10.1023/a:1016381028734
• 发表时间: 2002
• 期刊: Acta biotheoretica
• 影响因子: 1.3
• 作者: Wallace,Rodrick

Adaptive chronic infection, structured stress, and medical magic bullets: do reductionist cures select for holistic diseases?

适应性慢性感染、结构性压力和医学灵丹妙药：还原论疗法是否会选择整体疾病？

• DOI: 10.1016/j.biosystems.2004.04.004
• 发表时间: 2004
• 期刊: Bio Systems.
• 作者: Wallace,Rodrick;Wallace,RobertG
• 通讯作者: Wallace,RobertG