CORE--BIOSTATISTICS AND COMPUTATIONAL BIOLOGY

核心--生物统计学和计算生物学

• 批准号: 6936117
• 负责人: Thomas B Kepler
• 金额: $ 22.8万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6936117
• 关键词: AIDS; HIV infections; bioinformatics; biomedical facility; computational biology; data collection methodology /evaluation; experimental designs; human data; immune response; mathematical model; nucleic acid sequence; patient /disease registry; protein sequence; statistics /biometry

DESCRIPTION (provided by applicant): The primary responsibilities of the Biostatistics and Computational Biology (BCB) research team will be to participate in the CFAR research effort by supplying experimental design and data-analytical consulting during the developmental stages of new projects and in the preparation of grant proposals and to work with investigators on innovative approaches to informatics and mathematical/statistical modeling. The areas supported will include clinical biostatistics and computational biology, including gene expression and all aspects of nucleic acid and protein sequence analysis. In collaboration with Duke University Laboratory of Computational Immunology, the BCB core will also support methodological development and mathematical modeling of viral and immune dynamics. There will be two modes of interaction with the CFAR investigators. Under the first, new innovative projects will be treated as collaborative endeavors with no charge-back to the client. The expectation is that compensation will accrue to the BCB as collaborators on grants and contracts arising from this new work. Furthermore, the BCB may gain the opportunity to submit applications for related methodological work. Under the second model, ongoing projects with funding for statistical and/or computational biological work as well as industry-sponsored projects can contract with the BCB on a for-fee basis. The BCB core is devoted to the establishment and maintenance of easy communication with the CFAR investigators and the other cores. The BCB director, Dr. Thomas B. Kepler, has expertise in immunology (and a secondary appointment in the Duke Department of Immunology) as well as computational biology and statistics, which are his primary research fields. The core group will be trained to understand the science and medicine and the language in which they are expressed.

描述（由申请人提供）：生物统计学和生物统计学的主要职责 计算生物学 (BCB) 研究团队将参与 CFAR 研究工作 在新项目的开发阶段和拨款提案的准备过程中提供实验设计和数据分析咨询，并与研究人员合作开发信息学和数学/统计建模的创新方法。支持的领域将包括临床生物统计学和计算生物学，包括基因表达以及核酸和蛋白质序列分析的各个方面。 BCB 核心还将与杜克大学计算免疫学实验室合作，支持病毒和免疫动力学的方法开发和数学建模。与 CFAR 调查员的互动有两种模式。在第一种情况下，新的创新项目将被视为合作成果，不会向客户退款。预计 BCB 作为合作者将通过这项新工作产生的赠款和合同获得补偿。此外，BCB 可能有机会提交相关方法学工作的申请。在第二种模式下，正在进行的为统计和/或计算生物学工作提供资金的项目以及行业赞助的项目可以签订合同 与 BCB 收费。 BCB 核心致力于建立和维护与 CFAR 调查员和其他核心的轻松通信。 BCB 主任 Thomas B. Kepler 博士拥有免疫学（并在杜克大学免疫学系担任次要职位）以及计算生物学和统计学方面的专业知识，这是他的主要研究领域。核心小组将接受培训，了解科学和医学以及表达它们的语言。