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Computational Core

计算核心

基本信息

批准号：
10229501
负责人：
Thomas B Kepler
金额：
$ 8.7万
依托单位：
BOSTON CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-08-01 至 2023-04-06
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10229501
关键词：
Achievement Address Adopted Affinity Antibodies Antibody Affinity Antigens B cell repertoire B-Lymphocytes Binding Cell Culture Techniques Cell Ontogeny Cells Collaborations Collection Computational Biology Computer software Computing Methodologies Data Data Analyses Data Analytics Data Management Resources Formulation Genes Goals Graph Human Resources Humoral Immunities Immunoglobulins Immunology Infection Influenza Influenza vaccination Knowledge Label Marshal Mathematics Metadata Methods Modeling Molecular Evolution Pattern Performance Probability Recording of previous events Research Research Personnel Research Project Grants Statistical Data Interpretation Statistical Methods Structure Techniques Uncertainty V(D)J Recombination Vaccines Work analytical method anti-influenza base computer program computing resources cross reactivity data access data management design large datasets open source programs response statistics success tool

项目摘要

Summary Core C, Kepler The overall goal of the research program is to design immunogens that elicit a broadly neutralizing response by applying the knowledge gained through the analysis of B-cell ontogeny following influenza-virus vaccination or infection. The achievement of this goal will require substantial use of methods from computational biology and statistics to effectively extract the relevant information from the large datasets that will be generated in pursuit of this goal. The primary objective of Core C (Computational Biology) is to provide the methods, expertise, and software to meet these essential needs. In particular, Core C will provide 1. Support to the P01 investigators for the analysis of immunoglobulin sequencing data, 2. Support for statistical data analysis including epitopic/paratopic distance and correlates of antibody function, and 3. A data management system for the organization and analysis of data generated within the program.

总结开普勒C核这项研究计划的总体目标是设计一种能引起广泛中和反应的免疫原通过应用通过分析流感病毒接种后B细胞个体发育获得的知识，或者感染实现这一目标将需要大量使用计算生物学的方法和统计数据，以有效地从将生成的大型数据集中提取相关信息，追求这个目标。核心C（计算生物学）的主要目标是提供方法，专业知识和软件来满足这些基本需求。核心C将提供 1.支持P01研究者分析免疫球蛋白测序数据， 2.支持统计数据分析，包括抗体的表位/互补位距离和相关性功能和 3.数据管理系统，用于组织和分析程序中生成的数据。