Computational Core
Computational Core
批准号:
10229501
负责人:
Thomas B Kepler
金额:
$8.7万
依托单位国家:
美国
项目类别:
财政年份:
2011
资助国家:
美国
项目状态:
已结题
起止时间:
2011-08-01 至 2023-04-06
关键词:
AchievementAddressAdoptedAffinityAntibodiesAntibody AffinityAntigensB cell repertoireB-LymphocytesBindingCell Culture TechniquesCell OntogenyCellsCollaborationsCollectionComputational BiologyComputer softwareComputing MethodologiesDataData AnalysesData AnalyticsData Management ResourcesFormulationGenesGoalsGraphHuman ResourcesHumoral ImmunitiesImmunoglobulinsImmunologyInfectionInfluenzaInfluenza vaccinationKnowledgeLabelMarshalMathematicsMetadataMethodsModelingMolecular EvolutionPatternPerformanceProbabilityRecording of previous eventsResearchResearch PersonnelResearch Project GrantsStatistical Data InterpretationStatistical MethodsStructureTechniquesUncertaintyV(D)J RecombinationVaccinesWorkanalytical methodanti-influenzabasecomputer programcomputing resourcescross reactivitydata accessdata managementdesignlarge datasetsopen sourceprogramsresponsestatisticssuccesstool
中文摘要
总结
英文摘要
Summary
Core C, Kepler
The overall goal of the research program is to design immunogens that elicit a broadly neutralizing response
by applying the knowledge gained through the analysis of B-cell ontogeny following influenza-virus vaccination
or infection. The achievement of this goal will require substantial use of methods from computational biology
and statistics to effectively extract the relevant information from the large datasets that will be generated in
pursuit of this goal. The primary objective of Core C (Computational Biology) is to provide the methods,
expertise, and software to meet these essential needs.
In particular, Core C will provide
1. Support to the P01 investigators for the analysis of immunoglobulin sequencing data,
2. Support for statistical data analysis including epitopic/paratopic distance and correlates of antibody
function, and
3. A data management system for the organization and analysis of data generated within the program.
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会议论文
Computational Component
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批准号:8717175
-
项目类别:
-
资助金额:$2.48万
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财政年份:2013
-
负责人:Thomas B Kepler
-
依托单位:
MICROSIMULATION OF ANTHRACIS-IMMUNE SYSTEM INTERACTION - ADJUVANT DEVELOPMENT
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批准号:8172397
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项目类别:
-
资助金额:$4.39万
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财政年份:2010
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负责人:Thomas B Kepler
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依托单位:
Modeling Immunity: responses to Bacilus anthracis and anthrax vaccination
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批准号:8159581
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项目类别:
-
资助金额:$1347.51万
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财政年份:2010
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负责人:Thomas B Kepler
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依托单位:
Biostatistical and Computational Biology
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批准号:7930105
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项目类别:
-
资助金额:$23.86万
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财政年份:2010
-
负责人:Thomas B Kepler
-
依托单位:
MICROSIMULATION OF ANTHRACIS-IMMUNE SYSTEM INTERACTION - ADJUVANT DEVELOPMENT
-
批准号:7958220
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项目类别:
-
资助金额:$4.39万
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财政年份:2009
-
负责人:Thomas B Kepler
-
依托单位:
MICROSIMULATION OF ANTHRACIS-IMMUNE SYSTEM INTERACTION
-
批准号:7715820
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项目类别:
-
资助金额:$2.85万
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财政年份:2008
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负责人:Thomas B Kepler
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依托单位:
MICROSIMULATION OF ANTHRACIS-IMMUNE SYSTEM INTERACTION
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批准号:7562688
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项目类别:
-
资助金额:$3.16万
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财政年份:2007
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负责人:Thomas B Kepler
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依托单位:
BIOINFORMATIC and COMPUTATIONAL BIOLOGY TRAINING PROGRAM
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批准号:7254253
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项目类别:
-
资助金额:$17.98万
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财政年份:2005
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负责人:Thomas B Kepler
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依托单位:
Modeling Immunity for Biodefense
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批准号:7952360
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项目类别:
-
资助金额:$205.81万
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财政年份:2005
-
负责人:Thomas B Kepler
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依托单位:
BIOINFORMATIC and COMPUTATIONAL BIOLOGY TRAINING PROGRAM
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批准号:6801265
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项目类别:
-
资助金额:$13.49万
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财政年份:2005
-
负责人:Thomas B Kepler
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依托单位:
CORE--BIOSTATISTICS AND COMPUTATIONAL BIOLOGY
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批准号:6936117
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项目类别:
-
资助金额:$22.8万
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财政年份:2005
-
负责人:Thomas B Kepler
-
依托单位:
BIOINFORMATIC and COMPUTATIONAL BIOLOGY TRAINING PROGRAM
-
批准号:7060326
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项目类别:
-
资助金额:$13.49万
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财政年份:2005
-
负责人:Thomas B Kepler
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依托单位:
Core--Computational medicine
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批准号:7052929
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项目类别:
-
资助金额:$17.12万
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财政年份:2005
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负责人:Thomas B Kepler
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依托单位:
Microsimulation of anthracis-immune system interaction
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批准号:6821849
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项目类别:
-
资助金额:$19.25万
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财政年份:2004
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负责人:Thomas B Kepler
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依托单位:
Microsimulation of anthracis-immune system interaction
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批准号:6902625
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项目类别:
-
资助金额:$23.1万
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财政年份:2004
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负责人:Thomas B Kepler
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依托单位:
Research Training in Immunology
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批准号:9292207
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项目类别:
-
资助金额:$24.58万
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财政年份:1988
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负责人:Thomas B Kepler
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依托单位:
Research Training in Immunology
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批准号:10246476
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项目类别:
-
资助金额:$29.26万
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财政年份:1988
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负责人:Thomas B Kepler
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依托单位:
Research Training in Immunology
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批准号:10024856
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项目类别:
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资助金额:$26.87万
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财政年份:1988
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负责人:Thomas B Kepler
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依托单位:
CORE--BIOSTATISTICS AND COMPUTATIONAL BIOLOGY
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批准号:7637985
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项目类别:
-
资助金额:$21.84万
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财政年份:--
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负责人:Thomas B Kepler
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依托单位:
Computational biology scientific research support component
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批准号:8681341
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项目类别:
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资助金额:$175.82万
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财政年份:--
-
负责人:Thomas B Kepler
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依托单位:
海外基金