Computational Component

计算组件

• 批准号: 8717175
• 负责人: Thomas B Kepler
• 金额: $ 2.48万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8717175
• 关键词: Affinity; Antibodies; B cell repertoire; Biological Assay; Computational Biology; Data; Exposure to; Genetic; Human Resources; Immune response; Infection; Informatics; Methods; Process; Research; Research Personnel; Structure; Vaccines; design; improved; novel vaccines; pathogen; tool

Core D will provide the informatics, computational biology, and statistical support for the analysis of antibody somatic genetics and the correlation of antibody genetics with affinity, neutralization capacity, and other correlates of protection. Core D personnel have developed state-of-the-art tools that permit such analyses to be conducted, and will apply these tools to the data generated by the investigators in the P01 research teams. Furthermore, Core D researchers will continue to develop methods as needed by the group as a whole.

核心D将为抗体体细胞遗传学的分析以及抗体遗传学与亲和力、中和能力和其他保护相关因素的相关性提供信息学、计算生物学和统计学支持。核心D人员已经开发了最先进的工具，可以进行这种分析，并将把这些工具应用于P01研究小组的调查人员产生的数据。此外，核心D研究人员将继续根据整个集团的需要开发方法。