ORWH: SCOR on Sex and Gender Factors Affecting Women's *

ORWH：影响女性的性和性别因素的 SCOR *

• 批准号: 6917920
• 负责人: KATHLEEN T. BRADY
• 金额: $ 89.21万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6917920
• 关键词: clinical research; drug abuse; female; gender difference; women' s health

DESCRIPTION (provided by applicant): The common thread that ties all of the projects of the proposed SCOR together is relapse to drug abuse. MUSC has demonstrated a long-standing interest in substance abuse research as is clearly evidenced by strength in both basic science and clinical research in this area. Importantly, the proposed investigative team has experience in conducting translational research in an NIAAA-funded center initiative since 1996. While our track record in research and clinical efforts in substance abuse is strong, MUSC does not presently have the same strength in women's health initiatives. The SCOR would provide a catalyst to growth in this area. In developing the SCOR application, we gathered individuals with a unique blend of expertise from across campus. The interdisciplinary and cross-college nature of this initiative should ensure the sharing of ideas from multiple perspectives and guarantee that the SCOR has maximum impact on research and the general culture within MUSC. Specific Aims of the MUSC SCOR: Specific Aim #1: To set the occasion for focused, coordinated, integrated and unified efforts along a single program of gender-related research in substance use disorders at MUSC. Specific Aim #2: To build an infrastructure to encourage and support gender-based research growth throughout the campus. Specific Aim #3: To attract trainees and new faculty to the area of research, particularly patient-oriented research, in women's health issues. Specific Aim #4: To centralize various individual research efforts currently underway, as well as those proposed in the SCOR. Specific Aim #5: To produce a regional education and training resource for research in women's health. There are a total of five research components. All are focused on gender issues in relapse to substance use disorders. However, the varied investigations range from an exploration of sex differences in response to pharmacologic agents to investigations of gender differences in drug reinstatement in rodents, craving in humans and gender-specific treatment paradigms. Component #1: Sex Differences in an Animal Model of Relapse: Dr. Ronald See, an experienced pharmacologist, will be exploring gender differences in several well-developed animal models of drug self-administration reinstatement. Component #2: Gender Differences in Response to Cues in Cocaine Dependence: Dr. Kathleen Brady will lead this study of gender differences in response to cocaine-related cues and negative emotional states in men and women. This study will take place in the GCRC and involves the measurement of HPA axis response as well as autonomic and subjective response. Component #3: Gender, Menstrual Cycle and Smoking Cue Reactivity: Dr. Himanshu Upadhyaya will conduct a project studying the effect of menstrual cycle on the reactivity to nicotine and negative affect cues in humans. Component #4: Gender Influence on Preclinical Alcohol Pharmacology: Dr. Larry Middaugh will be using a rodent model to investigate the impact of gender and estrus state on the rewarding effects of ethanol and ethanol-conditioned stimuli. Component #5: Vocational Training for Drug-Dependent Women. Dr. Carrie Randall, the Co-PI of this project, will lead the research team of nurses and an experimental psychologist in this applied research project investigating gender-specific vocational services programs in unemployed recovering substance abusing women. This is an opportune time to develop a focused effort on research in women's health at MUSC. In terms of the thematic focus of the proposed SCOR, there is a convergence of opportunities and expertise in translational research in neuroscience and addiction. A cadre of talented and experienced basic scientists and clinical researchers from throughout MUSC interested in the SCOR has emerged and interdisciplinary collaboration and communication has been established. There is strong support from the leadership of MUSC. The focus on women's health and substance use disorders is sorely needed and complements many of the ongoing University efforts. Thus, the timing and thematic focus seem to ideally support the development of a Specialized Center of Research on Sex and Gender Factors Affecting Women's Health at MUSC.

描述(由申请人提供)： 将拟议的SCOR的所有项目联系在一起的共同主线是旧病复发。MUSC对药物滥用研究表现出长期的兴趣，这一领域的基础科学和临床研究的实力清楚地证明了这一点。重要的是，拟议的调查小组自1996年以来在NIAAA资助的中心倡议中拥有进行翻译研究的经验。虽然我们在药物滥用方面的研究和临床工作记录良好，但MUSC目前在妇女健康倡议方面没有同样的实力。SCOR将为这一领域的增长提供催化剂。 在开发SCOR应用程序的过程中，我们从整个校园收集了具有独特专业知识的人员。这一倡议的跨学科和跨学院性质应确保从多个角度交流思想，并保证SCOR对MUSC的研究和一般文化产生最大影响。 MUSC SCOR的具体目标： 具体目标#1：为MUSC物质使用障碍性别相关研究的单一项目提供集中、协调、综合和统一的努力机会。 具体目标2：建立一个基础设施，以鼓励和支持校园内基于性别的研究增长。 具体目标#3：吸引受训人员和新教师进入妇女健康问题的研究领域，特别是以病人为导向的研究。 具体目标#4：集中目前正在进行的各种个人研究工作，以及SCOR中提议的工作。 具体目标5：为妇女健康研究提供区域教育和培训资源。 总共有五个研究部分。所有这些都集中在复发性药物使用障碍的性别问题上。然而，不同的研究范围从对药物反应的性别差异的探索到对啮齿动物恢复药物的性别差异、人类的渴望和针对性别的治疗范例的调查。 组成部分1：复发动物模型中的性别差异：经验丰富的药理学家Ronald See博士将在几个发展良好的恢复药物自我给药的动物模型中探索性别差异。 第二部分：可卡因依赖线索反应的性别差异：凯瑟琳·布雷迪博士将领导这项研究，研究男性和女性对可卡因相关线索和消极情绪状态的反应的性别差异。这项研究将在GCRC进行，涉及HPA轴反应以及自主和主观反应的测量。 内容3：性别、月经周期和吸烟线索反应：Himanshu Upadhyaya博士将开展一个项目，研究月经周期对人体对尼古丁和负性情绪线索的反应性的影响。 组成部分4：性别对临床前酒精药理学的影响：Larry Middaugh博士将使用一个啮齿动物模型来研究性别和发情状态对乙醇和乙醇条件刺激的奖励效应的影响。 构成部分5：药物依赖妇女的职业培训。该项目的合作伙伴Carrie Randall博士将领导由护士和实验心理学家组成的研究团队，在这一应用研究项目中调查失业康复药物滥用妇女的特定性别职业服务计划。 这是在南加州大学集中力量开展妇女健康研究的好时机。就拟议的SCOR的主题重点而言，神经科学和成瘾方面的翻译研究机会和专业知识汇聚在一起。来自南加州大学各地对SCOR感兴趣的有才华和经验的基础科学家和临床研究人员组成的干部队伍已经出现，并建立了跨学科的合作和交流。得到了MUSC领导层的大力支持。对妇女健康和药物使用障碍的关注是迫切需要的，这是对大学正在进行的许多努力的补充。因此，这一时机和主题重点似乎理想地支持在南加州大学建立一个影响妇女健康的性别和性别因素专门研究中心。