Assessment Of Multiple Analytes In Women With Osteoporos

骨质疏松症女性多种分析物的评估

• 批准号: 7013041
• 负责人: Terry M. Phillips
• 金额: --
• 依托单位: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7013041
• 关键词: analytical method; capillary electrophoresis; clinical research; comorbidity; depression; epidemiology; female; human subject; immunoaffinity chromatography; method development; microarray technology; neuropeptides; osteoporosis; patient oriented research; women' s health

Bone loss in women pre- and post-menopause is a serious clinical condition affecting a reasonably large proportion of the general public. Depression is a compounding condition that has been shown to accentuate pathways leading to bone loss and suggesting a mind-body connection. The POWER study conducted at the NIH Clinical Center is designed to study the interactions of depression and severity of osteoporosis in pre-menopausal women. The DBEPS Ultramicro Analytical Immunochemistry Resource has undertaken to develop a panel of analytical techniques (recycling immunoaffinity chromatography [RIC]; immunoaffinity microarrays; immunoaffinity capillary electrophoresis [ICE]) to study a number of different systemic pathways that possibly may be involved in the connection between osteoporosis and depression. To date cohorts of both normal and depressed age-matched women have been recruited into the study. The study is ongoing, and although many potentially interesting findings have arisen, the cohorts are double-blinded and the codes will not be broken until the end of the recruitment phase.

绝经前和绝经后妇女的骨丢失是一种严重的临床状况，影响相当大比例的公众。抑郁症是一种复合性疾病，已被证明会加重导致骨质流失的途径，并暗示身心联系。在NIH临床中心进行的POWER研究旨在研究绝经前妇女抑郁症和骨质疏松症严重程度的相互作用。DBEPS超微分析免疫化学资源已着手开发一组分析技术（再循环免疫亲和色谱[RIC];免疫亲和微阵列;免疫亲和毛细管电泳[ICE]），以研究可能参与骨质疏松症和抑郁症之间联系的许多不同的系统途径。到目前为止，正常和抑郁年龄匹配的女性队列已被招募到研究中。该研究正在进行中，尽管出现了许多潜在的有趣结果，但队列是双盲的，直到招募阶段结束才揭盲。