2006 Diffraction Methods in Structual Biology Conference

描述(由申请人提供)：将于2006年7月16日至21日在缅因州刘易斯顿的贝茨学院举行的戈登研究会议：结构生物学中的衍射方法，请提供部分支持。多年来，这个两年一度的会议一直被誉为主要会议，专注于对阐明生物分子结构至关重要的衍射方法的发展。2006年的会议包括介绍中子衍射、电子显微镜技术、电子衍射和全细胞衍射成像。加强所有这些研究领域之间的互动对于结构生物学领域的未来发展至关重要，特别是为了解决未来的NIH路线图倡议，这些倡议将利用各种实验和计算技术解决许多数量级的成像问题。其他会议将是介绍和讨论NIGMS计划在结构基因组学和膜蛋白生产方面正在开发的一些新技术的论坛。为了推动衍射方法的发展，X射线数据收集、分析、结构确定和验证领域的领导者将介绍他们的最新方法学进展。这总是为参与者提供一个很好的机会，让他们直接从新方法的开发者那里学习，并将这些知识带回他们的家乡机构。参与者以前包括衍射法的开发者，以及那些将这些方法应用于生物分子结构和功能研究的人。2006年，衍射界以外的邀请正在扩大范围，这是有意识地决定将相关但目前尚未整合的领域的研究人员聚集在一起的结果。演讲者将包括该领域最知名的一些人，以及开始崭露头角的年轻调查人员。戈登会议是非正式的，有足够的机会让大约125名与会者在餐饮和其他活动中与大约30名演讲者互动。将鼓励青少年参加，并在演讲后有时间进行讨论，并举行一次专门讨论从海报演示中挑选出来的演讲的会议。

DESCRIPTION (provided by applicant): Partial support is requested for the Gordon Research Conference: Diffraction Methods in Structural Biology to be held at Bates College, Lewiston, Maine; July 16 through 21, 2006. This biennial conference has, for many years, had the reputation as the premier conference focusing on the development of the diffraction methods that are central to the elucidation of biomolecular structure. Sessions in the 2006 meeting include presentations about neutron diffraction, electron microscopy techniques, electron diffraction, and whole cell diffraction imaging. An increased interaction between all of these research areas is essential for the future development of the field of structural biology, in particular to address future NIH Roadmap initiatives that will tackle imaging problems across many orders of magnitude using a wide variety of experimental and computational techniques. Other sessions will be forums for the presentation and discussion of some of the new technologies being developed by NIGMS programs in structural genomics and membrane protein production. To advance the development of diffraction methods, leaders in the fields of X-ray data collection, analysis, structure determination and validation will present their recent methodological advances. This always provides a great opportunity for participants to learn directly from the developers of new methods, and take this knowledge back to their home institutions. Participants have previously included developers of diffraction methodology, and those applying these methods to studies of biomolecular structure and function. For 2006, the invitations outside the diffraction community are broadening the scope, the result of a conscious decision to bring together researchers from related, but currently not integrated, fields. Speakers will include some of the best known in the field, along with young investigators beginning to make their mark. Gordon conferences are informal with ample opportunity for approximately 125 participants to interact with about 30 speakers at meals and other events. Junior participation will be encouraged with time for discussion after talks and a session devoted to talks selected from the poster-presentations.