ALS Efficiently Networking Advanced Beam Line Experiments (ALS-ENABLE)

摘要/Abstract 本提案的总体目标是提供一个综合的、高效的同步加速器结构生物学资源， 研究界。此资源称为ALS-ENABLE，将位于高级光源 (ALS)在加州的伯克利。它将为成熟的结构生物学技术提供一个透明的接口 在ALS，并被设计为优化的机会，成功的结构确定的常规和 具有挑战性的问题。将提供多种访问机制，包括现场、远程、邮件和协作访问机制。 提供，用户将被引导通过最合适的路线，以回答他们的生物学问题。 问题该资源将利用其他公司在建设和运营方面的大量投资， 资助机构、工业界和学术界。该资源有3个技术运营核心（TOC）， 满足研究界的特定需求：1）快速反应晶体学，2）高质量和高 通过小角度X射线散射，和3）专门的晶体学。多方面的培训和 外联方案将包括面对面培训、远程和在线材料以及培训小组。的 资源将有一个强大的网络存在，在同行评审的出版物中代表，并参与 专业会议和研讨会，以促进ALS-ENABLE功能，招募新用户，并报告 为更大的结构生物学社区提供资源技术。资源将由一个 管理核心，这将确保本地，远程和协作访问保持对等， 审查束流时间提案。基于对指标的评估和用户反馈，我们将不断改进 通过ALS-ENABLE门户网站和实验资源进行用户交互。

Overall Summary/Abstract The overall goal of this proposal is to provide an integrated, efficient synchrotron structural biology Resource to the research community. This Resource, called ALS-ENABLE, will be located at the Advanced Light Source (ALS) in Berkeley, California. It will provide a transparent interface to the mature structural biology technologies at the ALS, and be designed to optimize the chances of successful structure determination for both routine and challenging problems. Multiple access mechanisms, including on site, remote, mail-in and collaborative, will be provided, and the users will be guided through the most appropriate routes for answering their biological question. The Resource will leverage the substantial investment in construction and operations by other funding agencies, industry and academia. The Resource has 3 Technology Operations Cores (TOCs) that address specific needs in the research community: 1) rapid response crystallography, 2) high quality and high throughput small angle X-ray scattering, and 3) specialized crystallography. A multifaceted training and outreach program will incorporate face-to-face training, remote and online materials, and training groups. The Resource will have a robust web presence, be represented in peer-reviewed publications, and participate in professional meetings and workshops to promote ALS-ENABLE capabilities, recruit new users, and report Resource technologies to the greater structural biology community. The Resource will be managed by an administrative core, which will ensure that local, remote, and collaborative access is maintained for peer- reviewed beamtime proposals. Based on evaluation of metrics and user feedback, we will consistently improve the user interactions through the ALS-ENABLE web portal and the experimental resources.