ALS Efficiently Networking Advanced Beam Line Experiments (ALS-ENABLE)

总体摘要/摘要 这项提案的总体目标是提供一个综合的、高效的同步加速器结构生物学资源来 研究界。该资源名为ALS-Enable，将位于高级光源 (ALS)，加利福尼亚州伯克利。它将为成熟的结构生物学技术提供一个透明的接口 在肌萎缩侧索硬化症中，并被设计为优化常规和 具有挑战性的问题。包括现场、远程、邮寄和协作在内的多种访问机制将是 提供，并将引导用户通过最合适的途径回答他们的生物 问题。该资源将利用其他公司在建设和运营方面的大量投资 资助机构、工业界和学术界。该资源有3个技术运营核心(TOC)， 满足研究界的特定需求：1)快速响应结晶学，2)高质量和高质量 通过小角X射线散射，以及3)特殊的结晶学。多方面的培训和 外展计划将包括面对面培训、远程和在线材料以及培训小组。这个 资源将拥有强大的网络存在，在同行评议的出版物中得到代表，并参与 专业会议和研讨会，以推广支持ALS的功能，招募新用户，并报告 向更大的结构生物界提供资源技术。该资源将由 管理核心，确保为对等用户维护本地、远程和协作访问- 已审查波束时间建议。基于对指标的评估和用户反馈，我们将始终如一地改进 通过支持ALS的门户网站和实验资源进行用户交互。

Overall Summary/Abstract The overall goal of this proposal is to provide an integrated, efficient synchrotron structural biology Resource to the research community. This Resource, called ALS-ENABLE, will be located at the Advanced Light Source (ALS) in Berkeley, California. It will provide a transparent interface to the mature structural biology technologies at the ALS, and be designed to optimize the chances of successful structure determination for both routine and challenging problems. Multiple access mechanisms, including on site, remote, mail-in and collaborative, will be provided, and the users will be guided through the most appropriate routes for answering their biological question. The Resource will leverage the substantial investment in construction and operations by other funding agencies, industry and academia. The Resource has 3 Technology Operations Cores (TOCs) that address specific needs in the research community: 1) rapid response crystallography, 2) high quality and high throughput small angle X-ray scattering, and 3) specialized crystallography. A multifaceted training and outreach program will incorporate face-to-face training, remote and online materials, and training groups. The Resource will have a robust web presence, be represented in peer-reviewed publications, and participate in professional meetings and workshops to promote ALS-ENABLE capabilities, recruit new users, and report Resource technologies to the greater structural biology community. The Resource will be managed by an administrative core, which will ensure that local, remote, and collaborative access is maintained for peer- reviewed beamtime proposals. Based on evaluation of metrics and user feedback, we will consistently improve the user interactions through the ALS-ENABLE web portal and the experimental resources.