GxE in Early Childhood: Twin Mothers

幼儿期的 GxE：双胞胎母亲

• 批准号: 7001193
• 负责人: ANDREW C. HEATH
• 金额: $ 63.11万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7001193
• 关键词: alcoholism /alcohol abuse; behavioral /social science research tag; child rearing; choice; clinical research; disease /disorder proneness /risk; early experience; female; gene environment interaction; human data; human subject; impulsive behavior; interview; longitudinal human study; mother child interaction; sex partner; twin /multiplet; young adult human (21-34)

DESCRIPTION (provided by applicant): This R01 application is one of four coordinated R01 Grants whose primary focus is the prospective characterization of effects on variation in the early social, emotional and behavioral problems of young children of gene-environment interplay (GE correlation and GxE interaction). This R01 makes use of a children-of-twins (COT) paradigm, building upon a prospective study of female like-sex twin pairs who were first assessed in adolescence (N=3277 twins assessed at wave 4 in early adulthood, ages 18-26). The COT design is particularly powerful for resolving (i) GE correlation effects associated with partner selection, (ii) GE correlation effects arising because heritable traits in parents predict increased probability of offspring high risk environmental exposures. Hypothesis-testing will be integrated within a theoretical framework that considers 3 meta-models -(behavioral under-control/disinhibition; behavioral inhibition/negative affect; pharmacologic impairment/substance dependence) for understanding how genetic and phenotypic differences between young women, in combination with differences in early experience (childhood trauma, rearing environment), contribute to risk of a progressive cascade of environmental risk for their present or future offspring. Gene-environment interplay is considered from a developmental perspective that considers pre-conception effects (partner selection, relationship formation), prenatal effects (early versus delayed pregnancy, maternal smoking and drinking during pregnancy), immediate post-natal environment (family socioeconomic disadvantage, high-risk neighborhood), early family environment (parent-parent relationship and relationship dissolution, and parenting behaviors; early traumatic events) and external environmental influences (access to high quality day-care, schooling). Two waves of data collection from the young adult female twin pairs, by telephone interview (target N=2622 interviews at wave one, N=2490 interviews at 2-year follow-up) will characterize relationship and pregnancy histories and early parenting behavior, perceived partner behavioral and emotional problems (projected N=2100 partners, with 20 percent completing interviews at each wave) and children's emotional and behavioral problems (projected N=2000 offspring), and will obtain updated assessments of twin risk-factors. In conjunction with R01s 2-4, these data will permit a powerful resolution of hypotheses concerning GE interplay effects on young children.

描述（由申请人提供）：此R01应用是四个协调的R01赠款之一，其主要重点是对基因环境相互作用（GE相关性和GXE相互作用）幼儿的早期社会，情感和行为问题的影响的前瞻性表征。这种R01利用了双胞胎儿童（COT）范式，基于对女性类似性的双胞胎对的前瞻性研究，这些研究首次在青春期进行了评估（n = 3277个双胞胎在成年后的第4波评估，18-26岁）。 COT设计对于解决（i）与合作伙伴选择相关的GE相关效应特别有力，（ii）GE相关效应会产生，因为父母的遗传性状可以预测后代高风险环境暴露的可能性增加。假设测试将集成到考虑3个元模型的理论框架中 - （行为下对控制/抑制；行为抑制/负面影响；药理损害/物质依赖性），以理解年轻女性之间的遗传和表型差异，与早期的经验差异（Case case case case Enigrionction case case Enigration a case Enigration a case traumage to a的差异）现在或将来的后代。从一个发展的角度考虑基因环境相互作用，该角度考虑了观察前的影响（伴侣选择，关系形成），产前效应（早期与延迟怀孕，孕妇在怀孕期间的吸烟和饮酒），直接产后的孕妇吸烟和饮酒，立即的后环境（家庭社会经济障碍，家庭经济较高的邻里，高风险的邻居，早期的关系）和父母的关系和父母的关系和父母的关系和父母的关系；环境影响（获得高质量的日间保健，上学）。 Two waves of data collection from the young adult female twin pairs, by telephone interview (target N=2622 interviews at wave one, N=2490 interviews at 2-year follow-up) will characterize relationship and pregnancy histories and early parenting behavior, perceived partner behavioral and emotional problems (projected N=2100 partners, with 20 percent completing interviews at each wave) and children's emotional and behavioral problems (projected N=2000 offspring), and will obtain updated对双风险因素的评估。与R01s 2-4结合使用，这些数据将允许对有关GE相互作用对幼儿影响的假设有强大的分辨率。