Aberrant functional connectivity in psychosis

精神病中的异常功能连接

• 批准号: 7101058
• 负责人: KENT A KIEHL
• 金额: $ 30.54万
• 依托单位: HARTFORD HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-27 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7101058
• 关键词: biomarker; bipolar depression; brain circulation; brain electrical activity; brain imaging /visualization /scanning; brain mapping; clinical research; data collection methodology /evaluation; early diagnosis; electrophysiology; evoked potentials; frontal lobe /cortex; functional ability; functional magnetic resonance imaging; human subject; intercellular connection; longitudinal human study; mental disorder diagnosis; neuropsychological tests; parietal lobe /cortex; schizophrenia; synapses; temporal lobe /cortex

DESCRIPTION (provided by applicant): Schizophrenia and psychotic bipolar disorder are debilitating mental illnesses characterized by diffuse emotional and cognitive impairment in many domains of mental function. One of the most pressing needs in psychiatry is the development of procedures to aid in the differential diagnosis of these two disorders at early stages. Accumulating evidence suggests that a cardinal abnormality in schizophrenia is aberrant connections between brain regions (i.e., functional connectivity). Aberrant functional connectivity has been observed in frontal and temporal lobes in schizophrenia during performance of target detection of low probability events. Patients with bipolar illness show impairments in multiple frontal circuits, basal ganglia, parietal cortex and cerebellum during target detection but show greater activity in temporal lobe regions compared to patients with schizophrenia. These results suggest psychotic bipolar illness may be associated with aberrant functional connectivity between frontal, striatal, and temporal lobe circuits - but in a pattern opposite to that observed in schizophrenia. The present proposal seeks to test the hypothesis that event related potential (ERP) topography, patterns of hemodynamic activity, and measures of functional connectivity, will reliably differentiate patients with schizophrenia from patients with psychotic bipolar illness during performance of target detection. High temporal resolution electrophysiological techniques and high spatial resolution hemodynamic imaging will be used to map the functional neural architecture associated with target detection. Independent Component Analyses will be used to examine the patterns of aberrant functional connectivity. Patients with clear diagnoses of schizophrenia or psychotic bipolar illness will be studied during the first week of a relapsing psychotic episode and again at 3 months and at 6 months postepisode. The longitudinal design will permit evaluation of state and trait markers of the two disorders. It is hypothesized that patients with schizophrenia will be reliably differentiated from patients with psychotic bipolar illness based on the pattern of hemodynamics and functional connectivity measures in frontal, temporal and subcortical structures. This work will be an important step in developing procedures to aid in the differential diagnosis of schizophrenia or psychotic bipolar illness at early stages of the disorder. The data also will permit an examination of psychotic symptoms (i.e., disorganization, reality distortion, and psychomotor poverty) associated with electrophysiological and hemodynamic measures of brain function.

描述（由申请人提供）：精神分裂症和精神病性双相情感障碍是一种使人衰弱的精神疾病，其特征是在许多精神功能领域弥漫性情感和认知障碍。精神病学最迫切的需求之一是发展程序，以帮助在早期阶段对这两种疾病进行鉴别诊断。越来越多的证据表明，精神分裂症的一个主要异常是大脑区域之间的异常连接（即，功能连接性）。在对低概率事件进行目标检测的过程中，在精神分裂症患者的额叶和颞叶中观察到异常的功能连接。与精神分裂症患者相比，双相情感障碍患者在目标检测过程中表现出多个额叶回路、基底神经节、顶叶皮层和小脑的损伤，但在颞叶区域表现出更大的活动。这些结果表明，精神病性双相障碍可能与额叶、纹状体和颞叶回路之间的异常功能连接有关，但与精神分裂症中观察到的模式相反。本提案旨在测试的假设，即事件相关电位（ERP）地形图，血流动力学活动的模式，和功能连接的措施，将可靠地区分精神分裂症患者与精神病性双相情感疾病患者在性能的目标检测。高时间分辨率电生理技术和高空间分辨率血流动力学成像将用于映射与目标检测相关的功能神经结构。独立成分分析将用于检查异常功能连接的模式。明确诊断为精神分裂症或精神病性双相障碍的患者将在复发性精神病发作的第一周以及发作后3个月和6个月再次进行研究。纵向设计将允许两种疾病的状态和性状标记的评估。据推测，精神分裂症患者将可靠地区分与精神病性双相情感疾病患者的基础上，在额叶，颞叶和皮质下结构的血流动力学和功能连接措施的模式。这项工作将是一个重要的一步，在发展程序，以帮助在早期阶段的精神分裂症或精神病性双相情感障碍的鉴别诊断。这些数据还将允许检查精神病症状（即，混乱、现实扭曲和精神运动贫困）与脑功能的电生理和血液动力学测量相关。