Socio-moral processing in psychopathy and substance abuse

描述(申请人提供)：精神病和药物滥用是严重的，共病的临床疾病与重大的民事和刑事破坏有关。在理解药物滥用和精神变态如何预测机构行为、犯罪累犯和治疗结果方面取得了重大进展。然而，关于这两种疾病的神经生物学以及它们是如何相互作用的，人们知之甚少。精神变态和药物滥用通常与决策受损有关，特别是道德决策。本提案的目的是研究精神病和药物滥用中与道德决策相关的共同和独特的神经系统。结构和功能成像方法将被用来绘制与处理基于语言和图片的道德决策范例相关的神经结构，这些男性罪犯根据精神病评分和药物滥用措施进行分层。这项研究将利用移动核磁共振系统，该系统将被部署到监狱设施，以收集有精神病和药物滥用问题的有代表性的罪犯样本。对这一样本的详细分析将使我们能够描绘出与精神病和药物滥用中道德决策受损相关的神经认知系统。这项研究可能会对设计用于治疗这些疾病的认知行为疗法的发展产生直接影响。与公共健康相关：犯罪造成的社会成本为每年1.33万亿美元，即美国每个男人、女人和儿童每人4400美元。心理健康和成瘾障碍是与犯罪行为相关的一些最常见的疾病。这项建议试图了解与有精神健康和成瘾问题的男性罪犯的道德决策相关的大脑系统。这项研究旨在帮助减轻社会上的心理健康、成瘾和犯罪负担。

DESCRIPTION (provided by applicant): Psychopathy and substance abuse are severe, co-morbid clinical disorders associated with significant civil and criminal disruption. Significant strides have been made in understanding how substance abuse and psychopathy predict institutional behavior, criminal recidivism, and treatment outcome. However, little is understood in terms of the neurobiology of these two disorders and how they interact. Psychopathy and substance abuse are commonly associated with impaired decision-making in general, moral decision-making in particular. The purpose of the present proposal is to examine the common and unique neural systems associated with moral decision-making in psychopathy and substance abuse. Structural and functional imaging methods will be used to map the neural architecture associated with processing linguistic and picture based moral decision-making paradigms in male offenders stratified by psychopathy scores and substance abuse measures. This research will utilize a mobile MRI system that will be deployed to prison facilities to collect representative samples of offenders with psychopathy and substance abuse problems. Detailed analyses of this sample will enable us to delineate the neurocognitive systems associated with impaired moral decision-making in psychopathy and substance abuse. This research may have a direct impact on the development of cognitive behavioral therapies designed to treat these conditions. PUBLIC HEALTH RELEVANCE: The societal cost of crime is $1.33 Trillion per year or $4400 per every man, woman, and child in the United States. Mental health and addiction disorders are some of the most common conditions associated with criminal behavior. This proposal seeks to understand the brain systems associated with moral decision-making in male offenders with mental health and addiction problems. This research is designed to help reduce the burden of mental health, addiction, and crime in society.