The Cognitive Neuroscience of Female Psychopathy

女性精神病的认知神经科学

• 批准号: 8436260
• 负责人: KENT A KIEHL
• 金额: $ 61.22万
• 依托单位: THE MIND RESEARCH NETWORK
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-17 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8436260
• 关键词: Accounting; Affective; Alcohol abuse; Alcohols; Amygdaloid structure; Anterior; Architecture; Attention; Auditory; Behavioral; Bilateral; Brain; Brain Injuries; Brain imaging; Brain region; Characteristics; Child; Clinical assessments; Cognitive; Crime; Data; Decision Making; Detection; Disease; Drug abuse; Female; Forensic Medicine; Functional Imaging; Functional Magnetic Resonance Imaging; Functional disorder; General Population; Hares; Health; Hippocampus (Brain); Image; Individual; Life Style; Magnetic Resonance Imaging; Maps; Measures; Medial; Mental Health; Mental disorders; Mind; Modeling; Monitor; Morals; Nature; Neuroanatomy; Neurobiology; Neurocognitive; Performance; Personality Disorders; Pharmaceutical Preparations; Prevalence; Principles of law and justice; Prisons; Process; Property; Psychometrics; Psychopath; Relative (related person); Research; Sampling; Schizophrenia; Severities; Societies; Solutions; Stimulus; Substance abuse problem; Superior temporal gyrus; System; Temporal Lobe; Testing; United States; Woman; Work; addiction; anti social; base; cognitive neuroscience; cost; criminal behavior; design; deviant; frontal lobe; hemodynamics; lifestyle factors; male; man; meetings; men; offender; psychopathic personality; relating to nervous system; response; stimulus processing

DESCRIPTION (provided by applicant): Psychopathy is a personality disorder comprised of a constellation of interpersonal, affective and behavioral characteristics. Individuals with psychopathy are responsible for a disproportionate amount of civil disruption, both criminal and noncriminal. The societal cost of psychopathy rivals that of other major mental illnesses of similar prevalence (~1% general population). However, relative to other major mental health disorders (e.g., schizophrenia), we are only beginning to understand the relevant neurobiology of psychopathy. Aspects of limbic and paralimbic brain regions including the amygdala, orbital frontal cortex, anterior temporal lobe, and anterior and posterior cingulate appear to be implicated in the disorder. Despite these advances, the cognitive neuroscience of psychopathy has nearly exclusively been limited to samples of men. Historical accounts and recent clinical assessment data suggest that the construct of psychopathy has similar psychometric properties in women as it does in men. However, to date there have been no cognitive neuroscience studies of psychopathy in women. The purpose of the present proposal is to examine the integrity of the limbic and paralimbic circuitry in female offenders with psychopathy. Electrophysiological and hemodynamic imaging data will be used to map the functional neural architecture associated with attentional control, error-monitoring, and moral decision-making in female offenders stratified by psychopathy scores. This research will utilize a mobile MRI system that will be deployed to prison facilities to collect a large sample of female offenders. Detailed analyses of this large sample of female offenders will enable us to comprehensively evaluate the paralimbic dysfunction hypothesis of psychopathy, the moderating impact of alcohol and substance abuse, and to evaluate psychometric models regarding the dimensional or categorical nature of the construct of psychopathy in women.

描述（由申请人提供）：精神病是一种人格障碍，由一系列人际、情感和行为特征组成。精神病患者要为不成比例的民事破坏负责，包括刑事的和非刑事的。精神病的社会成本可与其他流行率相似的主要精神疾病相媲美（约占总人口的1%）。然而，相对于其他主要的精神疾病（如精神分裂症），我们才刚刚开始了解精神病的相关神经生物学。包括杏仁核、眶额叶皮层、前颞叶和前后扣带在内的大脑边缘和旁边缘区域的各个方面似乎都与这种疾病有关。尽管取得了这些进展，但精神病的认知神经科学研究几乎完全局限于男性样本。历史记录和最近的临床评估数据表明，精神病的构造在女性和男性中具有相似的心理测量特性。然而，到目前为止，还没有关于女性精神病的认知神经科学研究。本研究的目的是研究患有精神病的女性罪犯大脑边缘和旁边缘回路的完整性。电生理和血流动力学成像数据将用于绘制与注意力控制、错误监测和道德决策相关的功能性神经结构，这些神经结构是根据精神病态分数分层的女性罪犯。这项研究将利用一种移动核磁共振成像系统，该系统将被部署到监狱设施中，以收集大量女性罪犯的样本。对大量女性罪犯样本的详细分析将使我们能够全面评估精神病的旁边缘功能障碍假说，酒精和药物滥用的缓和影响，并评估关于女性精神病构建的维度或分类性质的心理测量模型。

项目成果

PSYCHOPATHY, BORDERLINE PERSONALITY DISORDER, AND SUBSTANCE USE IN INCARCERATED FEMALES.

• DOI: 10.1177/00938548211033336
• 发表时间: 2021-12
• 期刊: CRIMINAL JUSTICE AND BEHAVIOR
• 影响因子: 2.1
• 作者: Edwards, Bethany G.;Maurer, J. Michael;Harenski, Carla L.;Kiehl, Kent A.
• 通讯作者: Kiehl, Kent A.

PSYCHOPATHY AND RISKY SEXUAL BEHAVIOR IN INCARCERATED WOMEN.

被监禁女性的精神病和危险性行为。

• DOI: 10.1177/00938548221105057
• 发表时间: 2022
• 期刊: Criminal justice and behavior
• 影响因子: 2.1
• 作者: Cook,AmandaM;Maurer,JMichael;Reynolds,BrookeL;Harenski,CarlaL;Kiehl,KentA
• 通讯作者: Kiehl,KentA

Neural correlates of moral and non-moral emotion in female psychopathy.

• DOI: 10.3389/fnhum.2014.00741
• 发表时间: 2014
• 期刊: Frontiers in human neuroscience
• 影响因子: 2.9
• 作者: Harenski CL;Edwards BG;Harenski KA;Kiehl KA
• 通讯作者: Kiehl KA

Automated patterns of head dynamics are associated with psychopathic traits in incarcerated women.

头部动态的自动模式与被监禁女性的精神病特征有关。

• DOI: 10.1016/j.paid.2022.111904
• 发表时间: 2023
• 期刊: Personality and individual differences
• 影响因子: 4.3
• 作者: Rodriguez,SamanthaN;Gullapalli,AparnaR;Tirrell,PalmerS;Maurer,JMichael;Egala,Ugesh;Edwards,BethanyG;Anderson,NathanielE;Harenski,CarlaL;Decety,Jean;Neumann,CraigS;Kiehl,KentA
• 通讯作者: Kiehl,KentA