Implantable DC Ablation Device for Tumor Therapy

描述(由申请人提供)：先进医疗电子公司(AME)建议开发一种原型植入式直流(DC)消融设备，用于治疗实体肿瘤。最近的数据支持这样一种假设，即DC消融术为那些以前几乎没有有效治疗选择的患者提供了一个可行的治疗选择，包括那些无法切除的肝或胰腺肿瘤。拟议的植入式直流消融设备将以比其他消融疗法更低的速度提供能量。治疗过程可能持续几个小时到几天，如果需要的话，可以重复几周。该植入式系统克服了直流电消融的主要缺点：治疗传递时间长。遥测植入物包装、电极设计和电池技术的最新进展使植入式直流消融设备在技术上目前是可行的。本项目的目标是设计、制造和测试一种实验装置，该装置适用于在实验中使用，以评估DC消融在大鼠模型中的抗肿瘤效果。

DESCRIPTION (provided by applicant): Advanced Medical Electronics (AME) proposes to develop a prototype implantable direct-current (DC) ablation device for treating solid cancerous tumors. Recent data support the hypothesis that DC ablation offers a viable treatment option to patients who previously had few or no effective therapy alternatives, including those with unresectable liver or pancreatic tumors. The proposed implantable DC ablation device will deliver energy at a lower rate than other ablative therapies. Therapy sessions may last from several hours to a few days and may be repeated, if needed for several weeks. The implantable system overcomes the primary drawback of DC ablation: long therapy delivery time. Recent advances in telemetry implant packaging, electrode design, and battery technology make an implantable DC ablation device technically feasible at this time. The objective of this project is to design, build, and test an experimental implant device suitable for use in experiments to evaluate the anti-tumor efficacy of DC ablation in a rat model.