Implantable DC Ablation Device for Tumor Therapy

用于肿瘤治疗的植入式直流消融装置

• 批准号: 6883276
• 负责人: Gregory John Seifert
• 金额: $ 9.75万
• 依托单位: ADVANCED MEDICAL ELECTRONICS CORPORATION
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-15 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6883276
• 关键词: bioengineering /biomedical engineering; biomaterial development /preparation; biomedical equipment development; biotechnology; electrodes; electronic stimulator; electrostimulus; implant; liver neoplasms; medical implant science; neoplasm /cancer therapy; pancreas neoplasms; telemetry; therapy design /development

DESCRIPTION (provided by applicant): Advanced Medical Electronics (AME) proposes to develop a prototype implantable direct-current (DC) ablation device for treating solid cancerous tumors. Recent data support the hypothesis that DC ablation offers a viable treatment option to patients who previously had few or no effective therapy alternatives, including those with unresectable liver or pancreatic tumors. The proposed implantable DC ablation device will deliver energy at a lower rate than other ablative therapies. Therapy sessions may last from several hours to a few days and may be repeated, if needed for several weeks. The implantable system overcomes the primary drawback of DC ablation: long therapy delivery time. Recent advances in telemetry implant packaging, electrode design, and battery technology make an implantable DC ablation device technically feasible at this time. The objective of this project is to design, build, and test an experimental implant device suitable for use in experiments to evaluate the anti-tumor efficacy of DC ablation in a rat model.

描述（由申请人提供）：Advanced Medical Electronics（AME）提出开发用于治疗实体癌肿瘤的原型植入式直流（DC）消融器械。 最近的数据支持这一假设，即DC消融为以前很少或没有有效治疗选择的患者提供了一种可行的治疗选择，包括那些患有不可切除的肝脏或胰腺肿瘤的患者。 申报的植入式DC消融器械将以低于其他消融治疗的速率输送能量。 治疗过程可能持续几个小时到几天，如果需要，可以重复几周。 植入式系统克服了DC消融的主要缺点：治疗输送时间长。 遥测植入物包装、电极设计和电池技术的最新进展使得植入式直流消融器械在技术上可行。 本项目的目的是设计、构建和测试一种适用于实验的实验植入装置，以评估DC消融在大鼠模型中的抗肿瘤疗效。