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System for Measuring Tissue Oxygenation

System for Measuring Tissue Oxygenation
组织氧合测量系统
批准号:
8882628
负责人:
Gregory John Seifert
金额:
$15.0万
依托单位国家:
美国
项目类别:
财政年份:
2015
资助国家:
美国
项目状态:
已结题
起止时间:
2015-04-01 至 2016-09-30

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中文摘要
翻译
 描述(申请人提供):先进医疗电子公司(AME)和我们的合作伙伴提出了一种微创系统,用于校准和重复测量周围组织的氧合。提出了一种基于第三代聚芳基甘氨酸树枝修饰的Pd-四苯并卟啉表面涂覆一层聚乙二醇膜的光耦合氧烷微传感器方法。特氟隆AF室将被用来隔离与身体接触的氧磷溶液,该系统通过磷光猝灭提供氧压测量。传感器的响应时间估计不到一分钟,稳定性超过16小时。该方法的优点包括坚固、快速插入和具有绝对校准的最小侵入性设备。在第一阶段,将指定、开发和评估原型系统。
英文摘要
 DESCRIPTION (provided by applicant): Advanced Medical Electronics (AME) and our partners propose a minimally-invasive system for calibrated and repeatable measurement of peripheral tissue oxygenation. An optically coupled oxyphor-based micro-sensor approach is proposed based on Pd-tetrabenzoporphyrin modified with generation-3 polyarylglycine dendrons and coated with a layer of polyethylene glycol. Teflon AF chambers will be utilized to sequester the Oxyphor solution from contact with the body and the system provides a measurement of oxygen pressure by phosphorescence quenching. Sensor response time is estimated to be less than one minute with stability for greater than 16 hours. Advantages to the approach include a robust, quickly inserted and minimally invasive device with absolute calibration. In phase 1, a prototype system will be specified, developed, and evaluated.
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