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System for Measuring Tissue Oxygenation

System for Measuring Tissue Oxygenation
组织氧合测量系统
批准号：
8882628
负责人：
Gregory John Seifert
金额：
$15.0万
依托单位：
ADVANCED MEDICAL ELECTRONICS CORPORATION
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
项目状态：
已结题
起止时间：
2015-04-01 至 2016-09-30
来源：
https://reporter.nih.gov/project-details/8882628
关键词：
Active SitesAffectAnesthesia proceduresBiochemistryBiophysicsBlood flowCaliberCalibrationClinicClinicalCollaborationsCoupledDendrimersDevicesDoctor of MedicineDoctor of PhilosophyElectron TransportElectronicsEnergy MetabolismEnergy TransferEngineeringEnsureErythrocyte TransfusionErythrocytesEvaluationFluorescenceFundingGenerationsHemorrhagic ShockHourImageIn VitroLaboratoriesLengthMarketingMeasurementMeasuresMedicalMedical DeviceMedical ElectronicsMedicineMetabolismMethodsMicroscopyMiniaturizationMonitorNeedlesOpticsOrgan failureOrganic ChemistryOxygenPathway interactionsPatientsPediatricsPennsylvaniaPerformancePeripheralPeripheral Vascular DiseasesPhasePhysiologicalPolyethylene GlycolsPositioning AttributePrincipal InvestigatorPropertyReaction TimeReadingRegional PerfusionResearchResearch PersonnelResearch PriorityRoleSolutionsSpecific qualifier valueSystemTechniquesTechnologyTeflonTherapy EvaluationTimeTissuesTo specifyTrauma patientUnited States National Institutes of HealthUniversitiesWireless Technologyabstractingbasebody systemcell growth regulationcommercializationcontextual factorsdesigndesign and constructionexperienceimprovedin vivoinstrumentinstrumentationminimally invasivenoveloptical fiberoptical sensorphosphorescencepressureprofessorprototypepublic health relevanceresearch studysensortissue oxygenationtool

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英文摘要
 DESCRIPTION (provided by applicant): Advanced Medical Electronics (AME) and our partners propose a minimally-invasive system for calibrated and repeatable measurement of peripheral tissue oxygenation. An optically coupled oxyphor-based micro-sensor approach is proposed based on Pd-tetrabenzoporphyrin modified with generation-3 polyarylglycine dendrons and coated with a layer of polyethylene glycol. Teflon AF chambers will be utilized to sequester the Oxyphor solution from contact with the body and the system provides a measurement of oxygen pressure by phosphorescence quenching. Sensor response time is estimated to be less than one minute with stability for greater than 16 hours. Advantages to the approach include a robust, quickly inserted and minimally invasive device with absolute calibration. In phase 1, a prototype system will be specified, developed, and evaluated.
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