Low-Cost, Portable, Point of Care Amplitude-Integrated Electroencephalography (aEEG)

项目摘要/摘要 该项目的目标是开发一种便携的、低成本的工具来帮助诊断和管理 出生时有神经系统并发症的新生儿。该项目将开发仪器技术和 相关软件可早期检测新生儿的神经性脑损伤和癫痫发作活动 在缺乏全套神经学诊断工具的护理设施中交付。在出生窒息的新生儿中， 癫痫发作非常常见，最常见的是亚临床发作。许多研究已经观察到，即使经历了 临床医生很难正确识别这一人群中的癫痫发作。随后，临床发作 并不真正代表癫痫发作是经常过度治疗和亚临床癫痫发作，包括癫痫持续状态， 得不到承认，得不到治疗。因此，使用连续视频-脑电图仪(EEG) 监测是识别和治疗这一人群癫痫发作的黄金标准。它在以下方面也非常有帮助 确定哪些儿童遭受了脑损伤，包括缺氧。这种资源密集型模式具有 成为许多三级医疗中心的标准护理，但不幸的是，许多人仍然无法获得 在较小的分娩机构的临床医生。定量脑电，包括使用幅度积分脑电(AEEG)， 已在大多数新生儿重症监护室得到广泛使用，并代表了一种更易于使用的床边工具 识别脑损伤和癫痫发作。拟议的第二阶段项目旨在设计、建造和评估一个低成本的 启用成本远程医疗的AEEG监护仪和支持以下功能的相关多仪器软件包 在以社区为基础的生育/护理机构中广泛使用AEEG。

Project Summary/Abstract The goal of this project is to develop a portable, low-cost tool to aid in the diagnosis and management of neonates born with neurologic complications. The project will develop instrumentation technology and associated software to enable early detection of neurologic brain injury and seizure activity for newborns delivered in care facilities that lack a full suite of neurological diagnostic tools. In neonates with birth asphyxia, seizures are very common and most frequently subclinical. Many studies have observed that even experienced clinicians have difficulty correctly identifying seizures in this population. Subsequently, clinical paroxysms that do not truly represent seizure are frequently over-treated and subclinical seizures, including status epilepticus, go unrecognized and untreated. As such, the use of continuous video‐electroencephalograph (EEG) monitoring is the gold standard for recognizing and treating seizures in this population. It is also very helpful at identifying which children have sustained brain injury, including hypoxia. This resource intense modality has become the standard of care at many tertiary medical centers but unfortunately remains unavailable to many clinicians at smaller birth facilities. Quantitative EEG, including the use of amplitude-integrated EEG (aEEG), has gained widespread use at most neonatal ICUs, and represents a more user-friendly bedside tool for identifying brain injury and seizures. The proposed phase II project aims to design, build, and evaluate a low- cost telemedicine-enabled aEEG monitor and associated multi-instrument software package that supports widespread use of aEEG in community-based birth / care facilities.