Low-Cost, Portable, Point of Care Amplitude-Integrated Electroencephalography (aEEG)

低成本、便携式、床旁幅值积分脑电图 (aEEG)

• 批准号: 9315618
• 负责人: Gregory John Seifert
• 金额: $ 77.52万
• 依托单位: ADVANCED MEDICAL ELECTRONICS CORPORATION
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9315618
• 关键词: Affect; Antiepileptic Agents; Area; Asphyxia; Asphyxia Neonatorum; Benign; Birth; Brain Injuries; Caring; Cerebrum; Child; Childhood; Clinic; Clinical; Code; Collaborations; Collection; Communities; Community Hospitals; Companions; Computer software; Consult; Data; Device or Instrument Development; Devices; Diagnosis; Diagnostic; Digital Signal Processing; Early Diagnosis; Electroencephalography; Ensure; Evaluation; Family Practice; Fright; Goals; Gold; Hypoxia; Infant; Intensive Care; Intervention; Lead; Letters; Limb structure; Medical; Medical Electronics; Medical center; Modality; Monitor; Movement; Names; Neonatal Intensive Care Units; Neonatology; Neurologic; Neurologic Dysfunctions; Neurological outcome; Neurologist; Newborn Infant; Nurseries; Outcome; Pediatrics; Pharmaceutical Preparations; Phase; Physicians; Population; Production; Provider; Research Personnel; Resources; San Francisco; Seizures; Signal Transduction; Specialist; Status Epilepticus; Subclinical Seizures; System; Technology; Telemedicine; Therapeutic; Training; Tremor; United States; base; cost; design; design and construction; experience; improved; instrument; instrumentation; natural hypothermia; neonatal hypoxic-ischemic brain injury; neonate; pediatrician; point of care; portability; professor; prototype; standard of care; telehealth; tool; transmission process; user-friendly

Project Summary/Abstract The goal of this project is to develop a portable, low-cost tool to aid in the diagnosis and management of neonates born with neurologic complications. The project will develop instrumentation technology and associated software to enable early detection of neurologic brain injury and seizure activity for newborns delivered in care facilities that lack a full suite of neurological diagnostic tools. In neonates with birth asphyxia, seizures are very common and most frequently subclinical. Many studies have observed that even experienced clinicians have difficulty correctly identifying seizures in this population. Subsequently, clinical paroxysms that do not truly represent seizure are frequently over-treated and subclinical seizures, including status epilepticus, go unrecognized and untreated. As such, the use of continuous video‐electroencephalograph (EEG) monitoring is the gold standard for recognizing and treating seizures in this population. It is also very helpful at identifying which children have sustained brain injury, including hypoxia. This resource intense modality has become the standard of care at many tertiary medical centers but unfortunately remains unavailable to many clinicians at smaller birth facilities. Quantitative EEG, including the use of amplitude-integrated EEG (aEEG), has gained widespread use at most neonatal ICUs, and represents a more user-friendly bedside tool for identifying brain injury and seizures. The proposed phase II project aims to design, build, and evaluate a low- cost telemedicine-enabled aEEG monitor and associated multi-instrument software package that supports widespread use of aEEG in community-based birth / care facilities.

项目总结/文摘