Low-Cost, Portable, Point of Care Amplitude-Integrated Electroencephalography (aEEG)

低成本、便携式、床旁幅值积分脑电图 (aEEG)

• 批准号: 9194546
• 负责人: Gregory John Seifert
• 金额: $ 49.21万
• 依托单位: ADVANCED MEDICAL ELECTRONICS CORPORATION
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9194546
• 关键词: Affect; Antiepileptic Agents; Area; Asphyxia; Asphyxia Neonatorum; Benign; Birth; Brain Injuries; Caring; Cerebrum; Child; Childhood; Clinic; Clinical; Code; Collaborations; Collection; Communities; Community Hospitals; Companions; Computer software; Consult; Data; Device or Instrument Development; Devices; Diagnosis; Diagnostic; Digital Signal Processing; Early Diagnosis; Electroencephalography; Ensure; Evaluation; Family Practice; Fright; Goals; Gold; Hypoxia; Infant; Intensive Care; Intervention; Lead; Letters; Limb structure; Marketing; Medical; Medical Electronics; Medical center; Modality; Monitor; Movement; Names; Neonatal Intensive Care Units; Neonatology; Neurologic; Neurologic Dysfunctions; Neurological outcome; Neurologist; Newborn Infant; Nurseries; Outcome; Pediatrics; Pharmaceutical Preparations; Phase; Physicians; Population; Production; Provider; Research Personnel; Resources; San Francisco; Seizures; Signal Transduction; Specialist; Status Epilepticus; Subclinical Seizures; System; Technology; Telemedicine; Therapeutic; Training; Tremor; United States; abstracting; base; cost; design; design and construction; experience; improved; instrument; instrumentation; natural hypothermia; neonatal hypoxic-ischemic brain injury; neonate; pediatrician; point of care; professor; prototype; standard of care; telehealth; tool; transmission process; user-friendly

Project Summary/Abstract The goal of this project is to develop a portable, low-cost tool to aid in the diagnosis and management of neonates born with neurologic complications. The project will develop instrumentation technology and associated software to enable early detection of neurologic brain injury and seizure activity for newborns delivered in care facilities that lack a full suite of neurological diagnostic tools. In neonates with birth asphyxia, seizures are very common and most frequently subclinical. Many studies have observed that even experienced clinicians have difficulty correctly identifying seizures in this population. Subsequently, clinical paroxysms that do not truly represent seizure are frequently over-treated and subclinical seizures, including status epilepticus, go unrecognized and untreated. As such, the use of continuous video‐electroencephalograph (EEG) monitoring is the gold standard for recognizing and treating seizures in this population. It is also very helpful at identifying which children have sustained brain injury, including hypoxia. This resource intense modality has become the standard of care at many tertiary medical centers but unfortunately remains unavailable to many clinicians at smaller birth facilities. Quantitative EEG, including the use of amplitude-integrated EEG (aEEG), has gained widespread use at most neonatal ICUs, and represents a more user-friendly bedside tool for identifying brain injury and seizures. The proposed phase II project aims to design, build, and evaluate a low- cost telemedicine-enabled aEEG monitor and associated multi-instrument software package that supports widespread use of aEEG in community-based birth / care facilities.

项目概要/摘要 该项目的目标是开发一种便携式、低成本的工具来帮助诊断和管理 出生时患有神经系统并发症的新生儿。该项目将开发仪器仪表技术和 相关软件能够及早检测新生儿的神经性脑损伤和癫痫活动 在缺乏全套神经诊断工具的护理机构中提供。对于出生窒息的新生儿， 癫痫发作非常常见，而且最常见的是亚临床症状。许多研究发现，即使是经历过 临床医生很难正确识别该人群的癫痫发作。随后，临床发作 并不真正代表癫痫发作经常是过度治疗和亚临床癫痫发作，包括癫痫持续状态， 得不到承认和治疗。因此，使用连续视频脑电图（EEG） 监测是识别和治疗该人群癫痫发作的金标准。它也非常有帮助 确定哪些儿童遭受了脑损伤，包括缺氧。这种资源密集型模式具有 成为许多三级医疗中心的护理标准，但不幸的是许多人仍然无法获得 较小的分娩机构的临床医生。定量脑电图，包括使用振幅积分脑电图 (aEEG)， 已在大多数新生儿 ICU 得到广泛使用，代表了一种更加用户友好的床边工具 识别脑损伤和癫痫发作。拟议的第二阶段项目旨在设计、建造和评估一个低 支持远程医疗的 aEEG 监视器和相关的多仪器软件包，支持 在社区分娩/护理机构中广泛使用 aEEG。