Retinal Prosthesis with Enhanced Thermal Imaging

具有增强热成像功能的视网膜假体

• 批准号: 8714976
• 负责人: Gregory John Seifert
• 金额: $ 22.09万
• 依托单位: ADVANCED MEDICAL ELECTRONICS CORPORATION
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8714976
• 关键词: Algorithms; Blindness; Brain; Cells; Characteristics; Clinical Trials; Color; Computer software; Data; Devices; Digital Signal Processing; Doctor of Philosophy; Electric Stimulation; Electrodes; Electronics; Elements; Equipment; Evaluation; Eye; Eyeglasses; FDA approved; Financial compensation; Future; Glass; Human; Image; Imagery; Implant; Institutes; Laboratories; Lead; Letters; Light; Lighting; Macular degeneration; Medical; Medical Electronics; Modality; Motor; Movement; Ophthalmology; Panthera leo; Patients; Phase; Physiologic pulse; Pigments; Principal Investigator; Process; Prosthesis; Radiation; Reading; Recording of previous events; Rehabilitation Centers; Research; Research Project Grants; Resolution; Retina; Retinal; Retinal Degeneration; Retinitis Pigmentosa; Shapes; Signal Transduction; Silicon; Site; Source; Specific qualifier value; System; Techniques; Technology; Temperature; Testing; Translating; Universities; Visible Radiation; Vision; Vision research; Visual; Visual Perception; Visually Impaired Persons; Work; blind; cost; design; detector; experience; human subject; image processing; improved; medical schools; meetings; multidisciplinary; novel; pattern perception; professor; prototype; public health relevance; research and development; research study; retinal prosthesis; systems research

DESCRIPTION (provided by applicant): We propose to develop and evaluate the utility of a thermal imaging system as an input modality to a retinal prosthetic. Retinal prostheses restore partial vision to people blinded by outer retinal degenerative diseases such as Retinitis Pigmentosa (RP) or Macular Degeneration. The Argus II Retinal Prosthesis System is intended to provide electrical stimulation of the retina to elicit visual perception in blind individuals wih severe to profound retinitis pigmentosa. The implanted epiretinal array provides a 10 x 6 grid of electrodes. Electrical pulses at these 60 pixel sites stimulate the retina's remaining cells and result in the perception of patterns of light in the brain. The current spatial resolution is only 0 total pixels. Ordinary light and color information is difficult for wearers to effectively process n many important tasks at this low resolution. Current compensation techniques in reduced resolution systems apply enhancement, magnification, and panning of visible light imagery, and these techniques have utility to retinal implants. However, other information sources such as thermal imaging more naturally align to the limited resolution of retinal arrays and may improve the utility of the system in important tasks such as people finding and mobility. The proposed project seeks to provide and experiment with thermal imagery as an input modality to retinal implants. A prototype system will be specified, designed, built, and evaluated in Argus II patients.

描述（由申请人提供）：我们建议开发和评估热成像系统作为视网膜假体输入模态的实用性。视网膜假体可以恢复因视网膜色素变性（RP）或黄斑变性等外部视网膜退行性疾病而失明的人的部分视力。Argus II视网膜假体系统预期用于为患有重度至重度视网膜色素变性的盲人提供视网膜电刺激，以激发视觉感知。植入的视网膜前阵列提供10 × 6的电极网格。在这60个像素点的电脉冲刺激视网膜的剩余细胞，并导致大脑对光模式的感知。当前空间分辨率总共只有0个像素。普通的光和颜色信息对于佩戴者来说很难在这种低分辨率下有效地处理许多重要任务。在降低分辨率系统中的当前补偿技术应用可见光图像的增强、放大和平移，并且这些技术对视网膜植入物具有实用性。然而，诸如热成像的其他信息源更自然地与视网膜阵列的有限分辨率对准，并且可以提高系统在诸如人员寻找和移动性的重要任务中的实用性。拟议的项目旨在提供和实验热成像作为视网膜植入的输入方式。将在Argus II患者中指定、设计、构建和评价原型系统。