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Retinal Prosthesis with Enhanced Thermal Imaging

具有增强热成像功能的视网膜假体

基本信息

批准号：
9265861
负责人：
Gregory John Seifert
金额：
$ 66.57万
依托单位：
ADVANCED MEDICAL ELECTRONICS CORPORATION
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-05-01 至 2020-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9265861
关键词：
Algorithms Blindness Brain Cells Characteristics Clinical Trials Color Computer software Development Devices Digital Signal Processing Doctor of Philosophy Electric Stimulation Electrodes Electronics Equipment Evaluation Eye Eyeglasses FDA approved Financial compensation Human Image Imagery Implant Institutes Lead Letters Light Lighting Macular degeneration Medical Medical Electronics Modality Motor Movement Operative Surgical Procedures Ophthalmology Panthera leo Patients Phase Physiologic pulse Pigments Principal Investigator Process Production Prosthesis Radiation Reading Recording of previous events Rehabilitation Centers Research Research Project Grants Resolution Retina Retinal Retinal Degeneration Retinitis Pigmentosa Shapes Signal Transduction Silicon Site Source Specific qualifier value System Systems Development Techniques Technology Temperature Testing Translating Universities Validation Visible Radiation Vision Vision research Visual Visual Perception Visually Impaired Persons Work blind computerized data processing design experience imaging system improved medical schools mid-career faculty multidisciplinary pattern perception prosthesis wearer prototype public health relevance retina implantation retinal prosthesis systems research vision rehabilitation

项目摘要

DESCRIPTION (provided by applicant): We propose to develop and evaluate the utility of a thermal imaging system as an input modality to a retinal prosthetic. Retinal prostheses restore partial vision to people blinded by outer retinal degenerative diseases such as Retinitis Pigmentosa (RP) or Macular Degeneration. The Argus II retinal prosthesis system is intended to provide electrical stimulation of the retina to elicit visual perception in blind individuals with severe to profound retinitis pigmentosa. The implanted epiretinal array provides a grid of electrodes. Electrical pulses at these sites stimulate the retina's remaining cells and result in te perception of patterns of light in the brain. Ordinary light and color information is difficult for wearers to effectively process in many important tasks with the limited perceived spatial resolution. Current compensation techniques in reduced resolution systems apply enhancement, magnification, and panning of visible light imagery, and these techniques have utility to retinal implants. However, other information sources, such as thermal imaging, more naturally align to the limited resolution of retinal arrays and improve the utility of the system i important tasks such as people finding and mobility. The proposed project seeks to provide thermal imagery as an input modality to retinal implants. Following successful development of a prototype thermal imaging system and promising results during tests in Argus II retinal prosthesis wearers in phase I, we are now proposing the development and validation of an integrated visible and thermal imaging system under phase II. A fully-integrated prototype system will be developed that includes visible and thermal cameras and associated digital signal processing software to provide user-controllable combined thermal/visible imagery options to prosthesis wearers. This new system will be evaluated in a substantial trial.

描述（由申请人提供）：我们建议开发和评估热成像系统作为视网膜假体输入方式的效用。视网膜假体可以帮助因视网膜色素变性 (RP) 或黄斑变性等外视网膜退行性疾病失明的人恢复部分视力。 Argus II 视网膜假体系统旨在为视网膜提供电刺激，以激发患有严重至极重度色素性视网膜炎的盲人的视觉感知。植入的视网膜前阵列提供电极网格。这些部位的电脉冲刺激视网膜的剩余细胞，并导致大脑对光模式的感知。普通的光和颜色信息很难获取佩戴者能够以有限的感知空间分辨率有效地处理许多重要任务。当前分辨率降低系统中的补偿技术应用可见光图像的增强、放大和平移，并且这些技术可用于视网膜植入。然而，其他信息源（例如热成像）更自然地适应视网膜阵列有限的分辨率，并提高了系统在人员查找和移动等重要任务中的实用性。拟议的项目旨在提供热图像作为视网膜植入物的输入方式。继成功开发原型热成像系统并在第一阶段 Argus II 视网膜假体佩戴者测试中取得可喜的结果后，我们现在提议在第二阶段开发和验证集成的可见光和热成像系统。将开发一个完全集成的原型系统，其中包括可见光和热成像相机以及相关的数字信号处理软件，以为假肢佩戴者提供用户可控的组合热/可见图像选项。这个新系统将通过大量试验进行评估。