Vanderbilt Mouse Metabolic Physiology Center

范德比尔特小鼠代谢生理学中心

• 批准号: 6909005
• 负责人: DAVID H WASSERMAN
• 金额: $ 46.27万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-15 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6909005
• 关键词: biomedical facility; cooperative study; diabetes mellitus; disease /disorder model; laboratory mouse; metabolism disorder

The proposed Mouse Metabolic Physiology Center (MMPC) is an interdisciplinary program that will expand the already extensive capacity at Vanderbilt to uniquely characterize the phenotype or genetically altered murine models of diabetes and related disorders. Moreover, it will provide a vehicle for making these novel resources available to investigators nationally. The MMPC will be self-contained in that it will have the capacity to perform husbandry and experimentation of a mouse line, analysis of tissue or blood samples from those mice, and management of data generated as a result of Center procedures. The MMPC will consist of five cores. The Administrative Core will provide scientific, financial, and administrative leadership, interact with program officials at the NIH, and administer the Pilot and Feasibility (P&F) Program. The Administrative Core will also support the role of the Center's Data Management Resource in developing and managing the Center mouse phenotyping database in a way that allows controlled access to investigators and other national centers. The Animal Care and Welfare Core will perform daily mouse care, mouse breeding, other national centers. The Animal Care and Welfare Core will perform daily mouse care, mouse breeding, collection of blood and tissues, and genotyping. The Metabolic Pathophysiology, the Vascular Pathology, and the Analytical Resources Core Laboratories will perform the phenotyping procedures. Pathophysiology, and the Analytical Resources Core Laboratories will perform the phenotyping procedures. Pathophysiology, and the Analytical Resources Core Laboratories will perform the phenotyping procedures. Services provided by cores will involve unique experimental procedures and analytical techniques scaled to the mouse that are generally not feasible for individual investigators to establish in their own laboratories. Vanderbilt is a leading site for research in diabetes and metabolism that is unified by the nation's first and consequently oldest federally funded diabetes center. Establishment of the MMPC will allow the expertise in diabetes and related disorders at Vanderbilt to be merged with developed and evolving resources to study the mouse.

拟议的小鼠代谢生理学中心（MMPC）是一个跨学科项目，将扩大范德比尔特大学已经广泛的能力，以独特地表征糖尿病和相关疾病的表型或基因改变的小鼠模型。此外，它将提供一种工具，使全国调查人员能够使用这些新颖的资源。 MMPC 将是独立的，因为它将有能力进行小鼠品系的饲养和实验、对这些小鼠的组织或血液样本进行分析以及对中心程序生成的数据进行管理。 MMPC 将由五个核心组成。行政核心将提供科学、财务和行政领导，与 NIH 的项目官员互动，并管理试点和可行性 (P&F) 项目。行政核心还将支持中心数据管理资源在开发和管理中心小鼠表型数据库方面的作用，从而允许研究人员和其他国家中心进行受控访问。动物护理和福利核心将负责日常小鼠护理、小鼠饲养和其他国家中心的工作。动物护理和福利核心将进行日常小鼠护理、小鼠饲养、血液和组织采集以及基因分型。代谢病理生理学、血管病理学和分析资源核心实验室将执行表型分析程序。病理生理学和分析资源核心实验室将执行表型分析程序。病理生理学和分析资源核心实验室将执行表型分析程序。核心提供的服务将涉及独特的实验程序和针对小鼠进行缩放的分析技术，这对于个别研究人员在自己的实验室中建立通常是不可行的。范德比尔特是糖尿病和新陈代谢研究的领先场所，由全国第一个也是最古老的联邦资助的糖尿病中心联合起来。 MMPC 的建立将使范德比尔特大学在糖尿病和相关疾病方面的专业知识与已开发和不断发展的资源相结合，以研究小鼠。