Vanderbilt Mouse Metabolic Physiology Center

拟议的小鼠代谢生理学中心（MMPC）是一个跨学科的计划，将扩大范德比尔特已经广泛的能力，以独特的表征表型或遗传改变的糖尿病和相关疾病的小鼠模型。此外，它将提供一个工具，使这些新的资源提供给全国的调查人员。MMPC将是独立的，因为它将有能力进行小鼠系的饲养和实验、分析这些小鼠的组织或血液样本以及管理中心程序产生的数据。MMPC将由五个核心组成。行政核心将提供科学，财务和行政领导，与NIH的项目官员互动，并管理试点和可行性（P&F）计划。行政核心还将支持中心的数据管理资源在开发和管理中心小鼠表型数据库方面的作用，以允许对研究者和其他国家中心进行受控访问。动物护理和福利中心将执行日常小鼠护理，小鼠育种，其他国家中心。动物护理和福利中心将进行日常小鼠护理、小鼠繁殖、血液和组织采集以及基因分型。代谢病理生理学、血管病理学和分析资源核心实验室将执行表型分析程序。病理生理学和分析资源核心实验室将执行表型分析程序。病理生理学和分析资源核心实验室将执行表型分析程序。核心所提供的服务将涉及独特的实验程序和分析技术，这些程序和技术通常不适合个别研究人员在自己的实验室中建立。范德比尔特是糖尿病和代谢研究的领先基地，由全国第一个也是最古老的联邦资助的糖尿病中心统一。MMPC的建立将使范德比尔特在糖尿病和相关疾病方面的专业知识与发达和不断发展的资源相结合，以研究小鼠。

The proposed Mouse Metabolic Physiology Center (MMPC) is an interdisciplinary program that will expand the already extensive capacity at Vanderbilt to uniquely characterize the phenotype or genetically altered murine models of diabetes and related disorders. Moreover, it will provide a vehicle for making these novel resources available to investigators nationally. The MMPC will be self-contained in that it will have the capacity to perform husbandry and experimentation of a mouse line, analysis of tissue or blood samples from those mice, and management of data generated as a result of Center procedures. The MMPC will consist of five cores. The Administrative Core will provide scientific, financial, and administrative leadership, interact with program officials at the NIH, and administer the Pilot and Feasibility (P&F) Program. The Administrative Core will also support the role of the Center's Data Management Resource in developing and managing the Center mouse phenotyping database in a way that allows controlled access to investigators and other national centers. The Animal Care and Welfare Core will perform daily mouse care, mouse breeding, other national centers. The Animal Care and Welfare Core will perform daily mouse care, mouse breeding, collection of blood and tissues, and genotyping. The Metabolic Pathophysiology, the Vascular Pathology, and the Analytical Resources Core Laboratories will perform the phenotyping procedures. Pathophysiology, and the Analytical Resources Core Laboratories will perform the phenotyping procedures. Pathophysiology, and the Analytical Resources Core Laboratories will perform the phenotyping procedures. Services provided by cores will involve unique experimental procedures and analytical techniques scaled to the mouse that are generally not feasible for individual investigators to establish in their own laboratories. Vanderbilt is a leading site for research in diabetes and metabolism that is unified by the nation's first and consequently oldest federally funded diabetes center. Establishment of the MMPC will allow the expertise in diabetes and related disorders at Vanderbilt to be merged with developed and evolving resources to study the mouse.