Marine and Freshwater Biomedical Sciences Center

海洋和淡水生物医学科学中心

• 批准号: 6888960
• 负责人: David E Williams
• 金额: $ 42.27万
• 依托单位: OREGON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6888960
• 关键词: aquatic biology; chemical carcinogen; clinical research; environment related neoplasm /cancer; fresh water environment; saltwater environment

The Marine and Freshwater Biomedical Sciences Center (MFBSC) uses aquatic species as models of human disease. The MFBSC consists of 6 Cores - 2 Research, 2 Facilities and Services, a Community Outreach, and a Pilot Project and Program Enrichment Core. The 2 Research Cores are supported by extramural grants and OSU, and no research funds or salary are requested. The Director utilizes Internal and Extemal Advisory Committees for guidance on scientific and administrative issues. The MFBSC provides facilities and training for scientists using aquatic models in biomedical research. Training (two NIEHS Training Grants) at the graduate, undergraduate, and postdoctoral levels are important goals of the MFBSC as is education and outreach (also supported by an NIEHS grant) to multiple community groups, including K-12 educators and the general public. The Center maintains its strengths in carcinogenesis, cancer chemoprevention, neurotoxicology and marine natural products. Addition of new faculty expands the focus into developmental toxicology and toxicogenomics. Successful synergism is evidenced by joint grants and publications. A new effort in toxicogenomics provides evidence of synergism among MFBS Centers. The MFBSC makes possible the pursuit of studies of environmental health important regionally, nationally and internationally. Important contributions in the last funding period include: 1) A successful clinical trial in China (directed by the NIEHS Center at Johns Hopkins with G. Bailey as Co-I) of a cancer chemopreventive agent first identified in the trout tumor model; 2) Completion of the largest cancer study in any animal model, that lowered the limit of detection of tumor incidence by more than an order of magnitude and tested the conservative linear model for risk extrapolation; 3) Development of a mobi(e fish cell biosensor of neurotoxins, including nerve gas agents; and 4) Discovery of several extremely potent neurotoxins from marine cyanobacteria that give new insights into the structure and function of the mammalian voltage-gated sodium channel, and may have therapeutic uses. Our goal over the next 5-year funding period is to build on these accomplishments by employing new approaches and technologies to pursue studies on the impacts of environmental chemicals on human health and conveying that information effectively to the public.

海洋和淡水生物医学科学中心(MFBSC)使用水生物种作为人类疾病的模型。MFBSC包括6个核心--2个研究、2个设施和服务、1个社区外联以及1个试点项目和计划丰富核心。这2个研究核心由校外补助金和OSU提供支持，不要求研究资金或工资。主任利用内部和外部咨询委员会就科学和行政问题提供指导。MFBSC为在生物医学研究中使用水生模型的科学家提供设施和培训。研究生、本科生和博士后层面的培训(两项NIEHS培训补助金)是MFBSC的重要目标，教育和向多个社区群体的外联(也得到NIEHS补助金的支持)也是如此， 包括K-12教育工作者和普通民众。该中心保持其在致癌、癌症化学预防、神经毒理学和海洋天然产品方面的优势。新教员的加入将重点扩展到发育毒理学和毒素基因组学。联合赠款和出版物证明了成功的协同作用。一项新的毒理基因组学研究为MFBS中心之间的协同作用提供了证据。MFBSC使开展具有区域、国家和国际重要性的环境健康研究成为可能。在上一个资助期内的重要贡献包括：1)在中国(由约翰霍普金斯大学NIEHS中心指导，G.Bailey为Co-I)成功地进行了一项在鲑鱼肿瘤模型中首次确定的癌症化学预防药物的临床试验；2)完成了动物模型中最大的癌症研究，将肿瘤发病率的检测下限降低了一个数量级以上，并测试了用于风险外推的保守线性模型；3)开发了MOBI(e鱼类细胞生物传感器) 4)从海洋蓝藻中发现了几种极其有效的神经毒素，使人们对哺乳动物电压门控钠通道的结构和功能有了新的见解，并可能具有治疗用途。我们在下一个五年资助期的目标是通过采用新的方法和技术来研究环境化学品对人类健康的影响，并有效地向公众传达这些信息，从而在这些成就的基础上再接再厉。