Epidemiology of CHD of Men Aged 40+

40岁男性冠心病流行病学

• 批准号: 7097415
• 负责人: AKIRA SEKIKAWA
• 金额: $ 20.76万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-05 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7097415
• 关键词: Japanese; Japanese American; alcoholic beverage consumption; atherosclerosis; body composition; cardiovascular disorder epidemiology; caucasian American; cholesterol; clinical research; coronary disorder; diet; dietary lipid; human middle age (35-64); human subject; male; nuclear magnetic resonance spectroscopy; nutrition related tag; obesity; omega 3 fatty acid; questionnaires; racial /ethnic difference; single photon emission computed tomography; smoking; thiocyanates; tobacco abuse

DESCRIPTION (provided by applicant): Substantial change toward a more Westernized lifestyle has taken place among younger individuals who were born after World War II (WWII) in non-Western countries including Japan. Data from national sample surveys in Japan clearly demonstrate that risk factor profiles for coronary heart disease (CHD) are very similar to those in the United States (US) in this post WWII cohort. Men in Japan do have a considerably higher prevalence of cigarette smoking and men in the US have a higher prevalence of obesity. CHD mortality among men in Japan is, however, still less than a half of that in the US. Careful review of mortality statistics confirms this. This difference remains unique among industrialized countries. The investigators propose to test the null hypothesis that there are no differences in the extent of atherosclerosis among Japanese men in Japan, Japanese American men in Hawaii, and US white and black men in this post WWII birth cohort. This project will be based on recent and ongoing successful Japan/US collaborations in the INTERMAP, INTERLIPID and Honolulu Heart Program studies including development of the first standardized US/Japan diet tables. We will examine 300 white men and 100 black men aged 40-49, randomly selected from Allegheny County, PA, 300 Japanese American men aged 40-49 from the population-based sample recruited from the offspring of the members of the Honolulu Heart Program cohort, and 300 Japanese men aged 40-49, randomly selected from Kusatsu City, Japan. The Japanese recruitment and examination has already been supported in Japan. The extent of atherosclerosis and risk factor profiles for CHD will be evaluated and compared, as well as the relationship of specific risk factors to the measures of atherosclerosis. The measures of subclinical disease proposed include calcium scores of coronary artery and aorta measured by electron beam computed tomography (EBCT) and carotid intima thickness measured by ultrasound. Other proposed measures include dietary intake by food frequency questionnaire, total cholesterol, LDLc, HDLc, lipids by NMR spectroscopy, blood pressure, cigarette smoking, thiocyanate, omega-3 fatty acid, alcohol consumption, body mass index (BMI), intra-abdominal fat, and others. Better understanding the reasons for the low Japanese rates may help us find new methods for prevention of CHD in all populations.

描述（由申请人提供）：在包括日本在内的非西方国家，二战后出生的年轻人向更西方化的生活方式发生了实质性的变化。日本国家抽样调查的数据清楚地表明，在二战后的队列中，冠心病（CHD）的危险因素概况与美国（US）非常相似。日本男性吸烟的比例要高得多，美国男性肥胖的比例也要高得多。然而，日本男性冠心病死亡率仍不到美国的一半。对死亡率统计数据的仔细审查证实了这一点。这种差异在工业化国家中仍然是独特的。研究人员建议检验零假设，即在日本的日本男性、夏威夷的日裔美国男性以及二战后出生队列中的美国白人和黑人男性的动脉粥样硬化程度没有差异。该项目将基于最近和正在进行的日本/美国在INTERMAP， inter脂质和檀香山心脏计划研究中的成功合作，包括开发第一个标准化的美国/日本饮食表。我们将从宾夕法尼亚州阿勒格尼县随机抽取300名40-49岁的白人男性和100名40-49岁的黑人男性，从檀香山心脏项目队列成员的后代中随机抽取300名40-49岁的日裔美国男性，以及从日本草津市随机抽取300名40-49岁的日本男性。日语的招聘和考试已经在日本得到了支持。将评估和比较动脉粥样硬化的程度和冠心病的危险因素概况，以及特定危险因素与动脉粥样硬化测量的关系。亚临床疾病的测量方法包括电子束计算机断层扫描（EBCT）测量冠状动脉和主动脉钙评分和超声测量颈动脉内膜厚度。其他建议的测量方法包括：通过食物频率问卷测定膳食摄入量、总胆固醇、低密度脂蛋白、高密度脂蛋白、核磁共振光谱测定血脂、血压、吸烟、硫氰酸盐、omega-3脂肪酸、饮酒、体重指数（BMI）、腹内脂肪等。更好地了解日本低发病率的原因可能有助于我们找到预防所有人群冠心病的新方法。