Dietary Patterns and Breast Density in Minnesota Women

明尼苏达州女性的饮食模式和乳房密度

• 批准号: 7051371
• 负责人: MARILYN TSENG
• 金额: $ 7.45万
• 依托单位: FOX CHASE CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-08 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7051371
• 关键词: Dietary; Patterns; Breast; Density; Minnesota

Interest in diet modification as a means of preventing breast cancer persists despite inconsistent results of epidemiologic studies. Previous studies, however, have focused primarily on single nutrients; they have not addressed the broader issue of whether overall diet or dietary patterns affect breast cancer risk, largely because of conceptual and methodological difficulties in defining and measuring dietary patterns. The proposed research will examine the association between dietary patterns and breast density among participants in the Minnesota Breast Cancer Family Cohort. Specific aims are to: (1) conduct a detailed characterization of dietary pattern intake in the cohort, and (2) examine associations dietary pattern-breast density associations, additionally exploring the role of specific dietary components such as saturated fat, and assessing whether dietary pattern-breast density associations differ by family history of breast cancer. The analysis will include women enrolled in the 1990 follow-up to a 1944-52 family study of breast cancer at the University of Minnesota. Participants were 1st- or 2nd degree relatives of breast cancer probands identified in the original family study, or spouses of male 1st or 2nd-degree relatives of the probands. Principal components analysis will be used to identify food intake patterns in 3,600 women who completed a 153-item food frequency questionnaire. Dietary pattern reliability and validity will be evaluated. Dietary pattern-breast density associations will be examined in approximately 1,875 women >=40 years of age who also provided a recent mammogram. Analyses will be repeated stratifying on family history of cancer, with family history assessed three ways, based on number of relationship to original breast cancer proband, a familial risk score reflecting family history of any cancer and ages at onset, and family history criteria indicating hereditary transmission of cancer. Additional analyses will compare principal components analysis-based measures with alternative methods for measuring dietary patterns. The proposed study will explore dietary patterns and breast density using detailed methods to insure reliable and valid measurement of dietary pattern intake. Findings will have implications for dietary change as a means of reducing breast cancer risk in women at average and at high risk for the disease.

尽管流行病学研究结果不一致，但人们对饮食调整作为预防乳腺癌的一种手段的兴趣仍然存在。然而，之前的研究主要集中在单一营养素上。他们没有解决整体饮食或饮食模式是否影响乳腺癌风险这一更广泛的问题，这主要是因为在定义和测量饮食模式方面存在概念和方法上的困难。拟议的研究将检查明尼苏达州乳腺癌家族队列参与者的饮食模式与乳房密度之间的关联。具体目标是：(1) 对队列中的饮食模式摄入量进行详细表征，(2) 检查饮食模式与乳房密度之间的关联，另外探索特定饮食成分（如饱和脂肪）的作用，并评估饮食模式与乳房密度之间的关联是否因乳腺癌家族史而异。该分析将包括参与明尼苏达大学 1944-52 年乳腺癌家庭研究 1990 年后续研究的女性。参与者是原始家庭研究中确定的乳腺癌先证者的一级或二级亲属，或者先证者的男性一级或二级亲属的配偶。主成分分析将用于确定 3,600 名女性的食物摄入模式，这些女性完成了包含 153 项食物频率的调查问卷。将评估饮食模式的可靠性和有效性。将对大约 1,875 名 40 岁以上的女性进行饮食模式与乳房密度关联性的检查，这些女性还提供了最近的乳房 X 光检查。将对癌症家族史进行重复分层分析，根据与原始乳腺癌先证者的关系数量、反映任何癌症家族史和发病年龄的家族风险评分以及表明癌症遗传性传播的家族史标准，以三种方式评估家族史。其他分析将比较基于主成分分析的措施与测量饮食模式的替代方法。拟议的研究将使用详细的方法探索饮食模式和乳房密度，以确保饮食模式摄入量的测量可靠且有效。研究结果将对饮食改变产生影响，将其作为降低女性乳腺癌平均风险和高风险女性患乳腺癌风险的一种手段。