Dietary Patterns and Breast Density in Minnesota Women

明尼苏达州女性的饮食模式和乳房密度

• 批准号: 7051371
• 负责人: MARILYN TSENG
• 金额: $ 7.45万
• 依托单位: FOX CHASE CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-08 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7051371
• 关键词: Dietary; Patterns; Breast; Density; Minnesota

Interest in diet modification as a means of preventing breast cancer persists despite inconsistent results of epidemiologic studies. Previous studies, however, have focused primarily on single nutrients; they have not addressed the broader issue of whether overall diet or dietary patterns affect breast cancer risk, largely because of conceptual and methodological difficulties in defining and measuring dietary patterns. The proposed research will examine the association between dietary patterns and breast density among participants in the Minnesota Breast Cancer Family Cohort. Specific aims are to: (1) conduct a detailed characterization of dietary pattern intake in the cohort, and (2) examine associations dietary pattern-breast density associations, additionally exploring the role of specific dietary components such as saturated fat, and assessing whether dietary pattern-breast density associations differ by family history of breast cancer. The analysis will include women enrolled in the 1990 follow-up to a 1944-52 family study of breast cancer at the University of Minnesota. Participants were 1st- or 2nd degree relatives of breast cancer probands identified in the original family study, or spouses of male 1st or 2nd-degree relatives of the probands. Principal components analysis will be used to identify food intake patterns in 3,600 women who completed a 153-item food frequency questionnaire. Dietary pattern reliability and validity will be evaluated. Dietary pattern-breast density associations will be examined in approximately 1,875 women >=40 years of age who also provided a recent mammogram. Analyses will be repeated stratifying on family history of cancer, with family history assessed three ways, based on number of relationship to original breast cancer proband, a familial risk score reflecting family history of any cancer and ages at onset, and family history criteria indicating hereditary transmission of cancer. Additional analyses will compare principal components analysis-based measures with alternative methods for measuring dietary patterns. The proposed study will explore dietary patterns and breast density using detailed methods to insure reliable and valid measurement of dietary pattern intake. Findings will have implications for dietary change as a means of reducing breast cancer risk in women at average and at high risk for the disease.

尽管流行病学研究的结果不一致，但人们仍然对改变饮食作为预防乳腺癌的一种手段感兴趣。然而，以前的研究主要集中在单一营养素上；它们没有解决更广泛的问题，即总体饮食或饮食模式是否会影响乳腺癌风险，这主要是因为在定义和衡量饮食模式方面存在概念和方法上的困难。这项拟议的研究将检查明尼苏达州乳腺癌家族队列参与者的饮食模式和乳房密度之间的关系。具体目标是：(1)对队列中的饮食模式摄入量进行详细的表征，(2)检查饮食模式与乳房密度之间的关系，另外探索特定饮食成分(如饱和脂肪)的作用，并评估饮食模式与乳房密度之间的关系是否因乳腺癌家族史而异。这项分析将包括在明尼苏达大学1944-52年乳腺癌家庭研究的1990年后续研究中登记的女性。参与者是原始家庭研究中确定的乳腺癌先证者的一级或二级亲属，或者先证者的男性一级或二级亲属的配偶。主成分分析将被用来确定3600名女性的食物摄入模式，她们完成了153个项目的食物频率问卷。将评估饮食模式的可靠性和有效性。饮食模式-乳房密度相关性将在大约1,875名40岁的女性中进行检查，她们也提供了最近的乳房X光检查。分析将重复对癌症家族史进行分层，根据与原始乳腺癌先证者的关系数量、反映任何癌症家族史和发病年龄的家族风险评分以及表明癌症遗传传播的家族史标准，对家族史进行三种评估。其他分析将比较以主成分分析为基础的措施与衡量饮食模式的替代方法。这项拟议的研究将使用详细的方法来探索饮食模式和乳房密度，以确保可靠和有效地测量饮食模式摄入量。这一发现将对改变饮食作为一种降低平均和高危女性乳腺癌风险的手段产生影响。