Diet and Breast Density over Time in US Chinese Women

在移民到美国后，中国女性经历了乳腺癌风险增加的过渡。了解外国出生的华裔美国女性随着时间的推移而发生的生活方式变化，例如饮食的变化，可能有助于我们理解文化适应的变化，特别是在成年后，如何影响乳腺癌风险。乳房密度是一种特别有用的风险标记，因为它与乳腺癌有很强的相关性，而且乳房密度随时间的变化可能会反映最近行为和暴露的影响。这项拟议的研究的目的是首次描述第一代华裔美国女性饮食和乳房密度随时间的变化，并检验饮食和其他与乳房密度变化的相关性。我们将招募420名绝经前或围绝经期华裔美国妇女，年龄为筛查乳房X光检查年龄，在美国居住=7年。数据收集将包括关于饮食摄入、文化适应以及健康和生育史的基线问卷；4天饮食召回；人体测量；血清胰岛素样生长因子-L水平；以及乳房密度筛查X光检查。将每隔12至24个月对相同因素采取两次后续措施。将描述饮食、其他行为因素和乳房密度的变化，以及饮食和其他与乳房密度变化相关的因素。研究团队和费城地区规模可观的华裔美国人社区的存在，为研究第一代华裔美国女性独特样本中饮食和乳房密度随时间的变化提供了第一个机会。研究结果将解决与文化适应相关的生活方式变化在多大程度上有助于华裔美国女性经历的乳腺癌风险的转变。他们还将通过检查成年期间风险因素的变化和确定最重要的具体因素来解决妇女乳腺癌风险的可调性问题，而不考虑种族。

Upon migration to the US, Chinese women undergo a transition to increased risk for breast cancer. An understanding of lifestyle changes that occur over time in foreign-born Chinese American women, such as changes in diet, could contribute to our understanding of how acculturative changes, particularly in adulthood, affect breast cancer risk. Breast density represents an especially useful marker of risk because of its strong association with breast cancer, and because change in breast density over time may reflect the effects of recent behaviors and exposures. The objectives of the proposed study are to characterize for the first time changes in diet and breast density over time in first-generation Chinese American women, and to examine dietary and other correlates of change in breast density. We will recruit 420 pre- or peri-menopausal Chinese American women of screening mammography age with US residence <=7 years. Data collection will include baseline questionnaires on dietary intake, acculturation, and health and reproductive histories; 4-day dietary recalls; anthropometric measures; serum insulin-like growth factor-l level; and a screening mammogram assessed for breast density. Two follow-up measures of the same factors will be obtained at 12- to 24-month intervals. Changes in diet, other behavioral factors, and breast density will be described, as well as dietary and other correlates of breast density change. The research team and the presence of a sizable Chinese American community in the Philadelphia area offer a first opportunity to examine changes in diet and breast density over time in a unique sample of first-generation Chinese American women. Findings will address the extent to which acculturation-related lifestyle changes contribute to the transition in breast cancer risk experienced by Chinese American women. They will also address the issue of modifiability of breast cancer risk in women regardless of ethnicity by examining changes in risk factors during adulthood and by identifying the specific factors of greatest importance.