Diet and Breast Density over Time in US Chinese Women

美国华裔女性的饮食和乳房密度随时间的变化

• 批准号: 7249333
• 负责人: MARILYN TSENG
• 金额: $ 50.77万
• 依托单位: FOX CHASE CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7249333
• 关键词: Acculturation; Address; Adopted; Adoption; Affect; Age; American; Area; Behavior; Behavioral; Chinese American; Chinese People; Clinical; Communities; Data Collection; Diet; Dietary intake; Ethnic Origin; Generations; Health Transition; Insulin-Like Growth Factor I; Intervention Trial; Life Style; Longitudinal Studies; Mammography; Measures; Mediating; Menopause; Philadelphia; Population; Questionnaires; Recruitment Activity; Reproductive Health; Reproductive History; Research; Risk; Risk Factors; Risk Marker; Sampling; Screening procedure; Serum; Somatomedins; Thinking; Time; Weight; Woman; Work; age related; behavioral health; breast density; cancer risk; day; experience; follow-up; malignant breast neoplasm; migration; residence; success

Upon migration to the US, Chinese women undergo a transition to increased risk for breast cancer. An understanding of lifestyle changes that occur over time in foreign-born Chinese American women, such as changes in diet, could contribute to our understanding of how acculturative changes, particularly in adulthood, affect breast cancer risk. Breast density represents an especially useful marker of risk because of its strong association with breast cancer, and because change in breast density over time may reflect the effects of recent behaviors and exposures. The objectives of the proposed study are to characterize for the first time changes in diet and breast density over time in first-generation Chinese American women, and to examine dietary and other correlates of change in breast density. We will recruit 420 pre- or peri-menopausal Chinese American women of screening mammography age with US residence <=7 years. Data collection will include baseline questionnaires on dietary intake, acculturation, and health and reproductive histories; 4-day dietary recalls; anthropometric measures; serum insulin-like growth factor-l level; and a screening mammogram assessed for breast density. Two follow-up measures of the same factors will be obtained at 12- to 24-month intervals. Changes in diet, other behavioral factors, and breast density will be described, as well as dietary and other correlates of breast density change. The research team and the presence of a sizable Chinese American community in the Philadelphia area offer a first opportunity to examine changes in diet and breast density over time in a unique sample of first-generation Chinese American women. Findings will address the extent to which acculturation-related lifestyle changes contribute to the transition in breast cancer risk experienced by Chinese American women. They will also address the issue of modifiability of breast cancer risk in women regardless of ethnicity by examining changes in risk factors during adulthood and by identifying the specific factors of greatest importance.

移民到美国后，中国女性经历了一个转变，患乳腺癌的风险增加。了解外国出生的华裔美国妇女随着时间的推移发生的生活方式变化，例如饮食变化，可能有助于我们了解文化适应性变化，特别是在成年期，如何影响乳腺癌风险。乳腺密度是一个特别有用的风险标志，因为它与乳腺癌有很强的关联，而且随着时间的推移，乳腺密度的变化可能反映了最近的行为和暴露的影响。这项研究的目的是首次描述第一代华裔美国妇女饮食和乳房密度随时间的变化，并研究饮食和其他相关因素与乳房密度变化的关系。我们将招募420名在美国居住<=7年、处于乳房X光筛查年龄的绝经前或围绝经期美籍华人女性。数据收集将包括关于饮食摄入、文化适应、健康和生殖史的基线问卷调查; 4天饮食回忆;人体测量;血清胰岛素样生长因子-l水平;以及评估乳腺密度的筛查乳房X线照片。将在12至24个月的时间间隔内获得相同因素的两个随访指标。饮食，其他行为因素和乳房密度的变化将被描述，以及饮食和乳房密度变化的其他相关因素。研究团队和费城地区一个相当大的华裔美国人社区的存在，为研究第一代华裔美国妇女的饮食和乳房密度随时间的变化提供了第一次机会。研究结果将解决与文化适应相关的生活方式改变在多大程度上有助于美国华裔女性经历的乳腺癌风险的转变。他们还将通过检查成年期风险因素的变化和确定最重要的具体因素，解决妇女乳腺癌风险的可改变性问题，无论其种族如何。