Diet and Breast Density over Time in US Chinese Women

描述（由申请人提供）：移民到美国后，中国女性经历了乳腺癌风险增加的过渡。了解在外国出生的华裔美国女性随着时间的推移而发生的生活方式变化，例如饮食的变化，可能有助于我们理解文化差异的变化，特别是在成年期，如何影响乳腺癌风险。乳房密度是一个特别有用的风险标志，因为它与乳腺癌有很强的联系，而且随着时间的推移，乳房密度的变化可能反映出最近的行为和暴露的影响。本研究的目的是首次描述第一代华裔美国女性的饮食和乳腺密度随时间的变化，并检查饮食和其他相关因素对乳腺密度变化的影响。我们将招募420名绝经前或围绝经期的华裔美国女性，筛查年龄在美国居住<=7年。数据收集将包括关于饮食摄入、文化适应、健康和生殖史的基线调查问卷；4天饮食召回；人体测量;血清胰岛素样生长因子1水平；还有乳房x光检查评估乳房密度。每隔12至24个月对相同因素进行两次随访。饮食、其他行为因素和乳房密度的变化，以及饮食和其他与乳房密度变化相关的因素都会被描述。研究小组和费城地区一个相当大的华裔美国人社区的存在提供了第一次机会，可以在第一代华裔美国女性的独特样本中检查饮食和乳房密度随时间的变化。研究结果将探讨与文化适应相关的生活方式改变在多大程度上促进了华裔美国女性乳腺癌风险的转变。他们还将通过检查成年期间风险因素的变化和确定最重要的具体因素，解决不分种族妇女乳腺癌风险可改变性的问题。

DESCRIPTION (provided by applicant): Upon migration to the US, Chinese women undergo a transition to increased risk for breast cancer. An understanding of lifestyle changes that occur over time in foreign-born Chinese American women, such as changes in diet, could contribute to our understanding of how acculturative changes, particularly in adulthood, affect breast cancer risk. Breast density represents an especially useful marker of risk because of its strong association with breast cancer, and because change in breast density over time may reflect the effects of recent behaviors and exposures. The objectives of the proposed study are to characterize for the first time changes in diet and breast density over time in first-generation Chinese American women, and to examine dietary and other correlates of change in breast density. We will recruit 420 pre- or peri-menopausal Chinese American women of screening mammography age with US residence <=7 years. Data collection will include baseline questionnaires on dietary intake, acculturation, and health and reproductive histories; 4-day dietary recalls; anthropometric measures; serum insulin-like growth factor-l level; and a screening mammogram assessed for breast density. Two follow-up measures of the same factors will be obtained at 12- to 24-month intervals. Changes in diet, other behavioral factors, and breast density will be described, as well as dietary and other correlates of breast density change. The research team and the presence of a sizable Chinese American community in the Philadelphia area offer a first opportunity to examine changes in diet and breast density over time in a unique sample of first-generation Chinese American women. Findings will address the extent to which acculturation-related lifestyle changes contribute to the transition in breast cancer risk experienced by Chinese American women. They will also address the issue of modifiability of breast cancer risk in women regardless of ethnicity by examining changes in risk factors during adulthood and by identifying the specific factors of greatest importance.