Dietary Patterns and Breast Density in Minnesota Women

明尼苏达州女性的饮食模式和乳房密度

• 批准号: 6943721
• 负责人: MARILYN TSENG
• 金额: $ 7.32万
• 依托单位: FOX CHASE CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-08 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6943721
• 关键词: breast neoplasms; cancer risk; clinical research; diet; dietary lipid; family genetics; female; human data; mammary gland; morphology; nutrition related neoplasm /cancer; nutrition related tag; nutritional epidemiology; saturated fat

DESCRIPTION (provided by applicant): Interest in diet modification as a means of preventing breast cancer persists despite inconsistent results of epidemiologic studies. Previous studies, however, have focused primarily on single nutrients; they have not addressed the broader issue of whether overall diet or dietary patterns affect breast cancer risk, largely because of conceptual and methodological difficulties in defining and measuring dietary patterns. The proposed research will examine the association between dietary patterns and breast density among participants in the Minnesota Breast Cancer Family Cohort. Specific aims are to: (1) conduct a detailed characterization of dietary pattern intake in the cohort, and (2) examine associations dietary pattern-breast density associations, additionally exploring the role of specific dietary components such as saturated fat, and assessing whether dietary pattern-breast density associations differ by family history of breast cancer. The analysis will include women enrolled in the 1990 follow-up to a 1944-52 family study of breast cancer at the University of Minnesota. Participants were 1st- or 2nd degree relatives of breast cancer probands identified in the original family study, or spouses of male 1st or 2nd-degree relatives of the probands. Principal components analysis will be used to identify food intake patterns in 3,600 women who completed a 153-item food frequency questionnaire. Dietary pattern reliability and validity will be evaluated. Dietary pattern-breast density associations will be examined in approximately 1,875 women >=40 years of age who also provided a recent mammogram. Analyses will be repeated stratifying on family history of cancer, with family history assessed three ways, based on number of relationship to original breast cancer proband, a familial risk score reflecting family history of any cancer and ages at onset, and family history criteria indicating hereditary transmission of cancer. Additional analyses will compare principal components analysis-based measures with alternative methods for measuring dietary patterns. The proposed study will explore dietary patterns and breast density using detailed methods to insure reliable and valid measurement of dietary pattern intake. Findings will have implications for dietary change as a means of reducing breast cancer risk in women at average and at high risk for the disease.

描述（由申请人提供）：尽管流行病学研究的结果不一致，但对饮食调整作为预防乳腺癌的一种手段的兴趣仍然存在。然而，以前的研究主要集中在单一营养素上;他们没有解决整体饮食或饮食模式是否会影响乳腺癌风险的更广泛问题，主要是因为定义和测量饮食模式的概念和方法上的困难。这项拟议中的研究将检查明尼苏达州乳腺癌家庭队列参与者的饮食模式和乳腺密度之间的关系。具体目标是：（1）对队列中的饮食模式摄入进行详细描述，（2）检查饮食模式与乳房密度的关联，另外探索特定饮食成分（如饱和脂肪）的作用，并评估饮食模式与乳房密度的关联是否因乳腺癌家族史而异。这项分析将包括明尼苏达大学1944- 1952年乳腺癌家族研究的1990年随访中登记的妇女。参与者是在原始家族研究中确定的乳腺癌先证者的一级或二级亲属，或先证者的男性一级或二级亲属的配偶。主成分分析将用于确定3,600名完成153项食物频率问卷的妇女的食物摄入模式。将评估膳食模式的信度和效度。饮食模式与乳腺密度的关系将在大约1,875名年龄≥ 40岁的女性中进行研究，这些女性也提供了最近的乳房X线照片。将对癌症家族史进行重复分层分析，根据与原始乳腺癌先证者的关系数量、反映任何癌症家族史和发病年龄的家族风险评分以及表明癌症遗传传播的家族史标准，以三种方式评估家族史。其他分析将比较基于主成分分析的测量方法与测量饮食模式的替代方法。拟议的研究将探讨饮食模式和乳房密度使用详细的方法，以确保可靠和有效的测量饮食模式的摄入量。研究结果将对饮食改变作为降低平均和高风险女性乳腺癌风险的一种手段产生影响。