Functional genomics of malaria liver infection and transmission

疟疾肝脏感染和传播的功能基因组学

• 批准号: nhmrc : GNT1123727
• 负责人: A/Pr Justin Boddey
• 金额: $ 47.01万
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/functional-genomics-malaria-infection-transmission/1347363
• 关键词: Functional; genomics; malaria; liver; infection

Chemotherapy is the front line defense against malaria but resistance is emerging. The WHO has advised that new drugs should target parasite stages that perpetuate the transmission of malaria to break the cycle of infection. We have identified proteins that are essential for the two transmissive stages of the most deadly parasite to infect their hosts. We will determine the precise function of these proteins and the mechanisms they govern. This may guide the development of new interventions.

化疗是对抗疟疾的第一线防御措施，但耐药性正在出现。世界卫生组织建议，新药应该针对使疟疾持续传播的寄生虫阶段，以打破感染循环。我们已经确定了最致命的寄生虫感染宿主的两个传播阶段所必需的蛋白质。我们将确定这些蛋白质的确切功能以及它们所支配的机制。这可能会指导新干预措施的发展。