Functional genomics of malaria liver infection and transmission
Functional genomics of malaria liver infection and transmission
批准号:
nhmrc : GNT1123727
负责人:
A/Pr Justin Boddey
金额:
$47.01万
依托单位国家:
澳大利亚
项目类别:
Career Development Fellowships
财政年份:
2017
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2017-01-01 至 --
中文摘要
化疗是对抗疟疾的第一线防御措施,但耐药性正在出现。世界卫生组织建议,新药应该针对使疟疾持续传播的寄生虫阶段,以打破感染循环。我们已经确定了最致命的寄生虫感染宿主的两个传播阶段所必需的蛋白质。我们将确定这些蛋白质的确切功能以及它们所支配的机制。这可能会指导新干预措施的发展。
英文摘要
Chemotherapy is the front line defense against malaria but resistance is emerging. The WHO has advised that new drugs should target parasite stages that perpetuate the transmission of malaria to break the cycle of infection. We have identified proteins that are essential for the two transmissive stages of the most deadly parasite to infect their hosts. We will determine the precise function of these proteins and the mechanisms they govern. This may guide the development of new interventions.
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Role of plasmepsin V and PTEX complex in Plasmodium liver infection
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批准号:nhmrc : GNT1139153
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项目类别:Project Grants
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资助金额:$84.84万
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负责人:A/Pr Justin Boddey
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依托单位:
The role of protein glycosylation in the malaria parasite
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负责人:A/Pr Justin Boddey
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依托单位:
The role of protein glycosylation in the malaria parasite
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批准号:nhmrc : GNT1139546
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项目类别:Project Grants
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资助金额:$64.44万
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财政年份:2018
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负责人:A/Pr Justin Boddey
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依托单位:
Role of plasmepsin V and PTEX complex in Plasmodium liver infection
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批准号:nhmrc : 1139153
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项目类别:Project Grants
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资助金额:$57.36万
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财政年份:2018
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负责人:A/Pr Justin Boddey
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依托单位:
Optimisation of a potent and fast acting antimalarial class that is orally efficacious in vivo
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批准号:nhmrc : GNT1135421
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项目类别:Development Grants
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资助金额:$68.39万
-
财政年份:2018
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负责人:A/Pr Justin Boddey
-
依托单位:
Optimisation of a potent and fast acting antimalarial class that is orally efficacious in vivo
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批准号:nhmrc : 1135421
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项目类别:Development Grants
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资助金额:$46.24万
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财政年份:2018
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负责人:A/Pr Justin Boddey
-
依托单位:
Functional genomics of malaria liver infection and transmission
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批准号:nhmrc : 1123727
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项目类别:Career Development Fellowships
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资助金额:$32.12万
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财政年份:2017
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负责人:A/Pr Justin Boddey
-
依托单位:
Effector export in P. falciparum infected human erythrocytes
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批准号:nhmrc : 1121178
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项目类别:Project Grants
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资助金额:$72.85万
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财政年份:2017
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负责人:A/Pr Justin Boddey
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依托单位:
Effector export in P. falciparum infected human erythrocytes
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批准号:nhmrc : GNT1121178
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项目类别:Project Grants
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资助金额:$106.69万
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财政年份:2017
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负责人:A/Pr Justin Boddey
-
依托单位:
Role of exported proteins in malaria parasite development in the liver
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批准号:nhmrc : 1049811
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项目类别:Project Grants
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资助金额:$34.71万
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财政年份:2013
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负责人:A/Pr Justin Boddey
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依托单位:
Function and inhibition of Plasmepsin V in targeting malaria virulence proteins into human erythrocytes
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批准号:nhmrc : 1010326
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项目类别:Project Grants
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资助金额:$27.2万
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财政年份:2011
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负责人:A/Pr Justin Boddey
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依托单位:
Identification of the Plasmodium falciparum translocon that exports parasite proteins into their erythocytic hosts.
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批准号:nhmrc : 516740
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项目类别:NHMRC Project Grants
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资助金额:$27.27万
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财政年份:2008
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负责人:A/Pr Justin Boddey
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依托单位:
characterisation of P. Flaciparum erythrocyte-targeted proteins
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批准号:nhmrc : 461281
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项目类别:Early Career Fellowships
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资助金额:$18.8万
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财政年份:2007
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负责人:A/Pr Justin Boddey
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依托单位:
国内基金
海外基金
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