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Role of plasmepsin V and PTEX complex in Plasmodium liver infection

Role of plasmepsin V and PTEX complex in Plasmodium liver infection
血浆蛋白酶 V 和 PTEX 复合物在疟原虫肝脏感染中的作用
批准号:
nhmrc : GNT1139153
负责人:
A/Pr Justin Boddey
金额:
$84.84万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 --

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中文摘要
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英文摘要
Plasmepsin V and PTEX are essential proteins for malaria parasites to grow inside red blood cells. These proteins control the export of parasite proteins into red cells, causing disease. Before red blood cells are infected, parasites invade liver cells. Plasmepsin V and PTEX are expressed during liver infection but their function is currently unknown. We hypothesise that they allow parasites to export proteins into liver cells in order to survive and, thus, are antimalarial drug targets.
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The role of protein glycosylation in the malaria parasite
The role of protein glycosylation in the malaria parasite
  • 批准号:
    nhmrc : GNT1139546
  • 项目类别:
    Project Grants
  • 资助金额:
    $64.44万
  • 财政年份:
    2018
  • 负责人:
    A/Pr Justin Boddey
  • 依托单位:
Role of plasmepsin V and PTEX complex in Plasmodium liver infection
Optimisation of a potent and fast acting antimalarial class that is orally efficacious in vivo
  • 批准号:
    nhmrc : GNT1135421
  • 项目类别:
    Development Grants
  • 资助金额:
    $68.39万
  • 财政年份:
    2018
  • 负责人:
    A/Pr Justin Boddey
  • 依托单位:
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