Role of plasmepsin V and PTEX complex in Plasmodium liver infection

血浆蛋白酶 V 和 PTEX 复合物在疟原虫肝脏感染中的作用

• 批准号: nhmrc : GNT1139153
• 负责人: A/Pr Justin Boddey
• 金额: $ 84.84万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-plasmepsin-v-liver-infection/1348208
• 关键词: Role; plasmepsin; PTEX; complex; Plasmodium

Plasmepsin V and PTEX are essential proteins for malaria parasites to grow inside red blood cells. These proteins control the export of parasite proteins into red cells, causing disease. Before red blood cells are infected, parasites invade liver cells. Plasmepsin V and PTEX are expressed during liver infection but their function is currently unknown. We hypothesise that they allow parasites to export proteins into liver cells in order to survive and, thus, are antimalarial drug targets.

Plasmepsin V和PTEX是疟原虫在红细胞内生长所必需的蛋白质。这些蛋白质控制寄生虫蛋白质向红细胞的输出，从而导致疾病。在红细胞被感染之前，寄生虫会侵入肝细胞。Plasmepsin V和PTEX在肝脏感染期间表达，但其功能目前尚不清楚。我们假设它们允许寄生虫为了生存而将蛋白质输出到肝细胞中，因此是抗疟疾药物的靶点。