Effector export in P. falciparum infected human erythrocytes

恶性疟原虫感染的人红细胞中的效应器输出

• 批准号: nhmrc : GNT1121178
• 负责人: A/Pr Justin Boddey
• 金额: $ 106.69万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/effector-export-p-human-erythrocytes/1347190
• 关键词: Effector; export; P.; falciparum; infected

We will investigate malaria, a parasitic disease that kills over 450,000 people a year. We will explore how the parasite identifies, invades and remodels the host cells in which it lives, scavenging nutrients and hiding from the immune system. We will characterize the proteins involved in these critical events, as they are potential targets for drugs. We will study how parasites cause disease and how the host responds to infection.

我们将调查疟疾，这是一种寄生虫病，每年造成45万人死亡。我们将探索寄生虫如何识别，入侵和重塑它所生活的宿主细胞，清除营养物质并躲避免疫系统。我们将描述参与这些关键事件的蛋白质，因为它们是药物的潜在靶点。我们将研究寄生虫如何引起疾病以及宿主如何对感染作出反应。