Role of exported proteins in malaria parasite development in the liver

每年有2.5亿多人感染疟疾，100多万人死亡。疟原虫成功的关键是能够在宿主细胞内生存，包括肝细胞和红细胞。在这里，我们的目标是确定疟原虫如何在肝细胞内生活，设计突变的寄生虫，不再这样做，并评估突变的寄生虫是否能保护未来的疟疾。我们的计划将使用最致命的人类寄生虫恶性疟原虫和啮齿动物寄生虫伯氏疟原虫。

Each year over 250 million people contract malaria and over 1 million die. The key to the malaria parasite’s success is the ability to live inside host cells, including hepatocytes and erythrocytes. Here, we aim to determine how the malaria parasite lives within hepatocytes, to engineer mutant parasites that can no longer do so and to assess whether mutant parasites confer protection against future malaria. Our program will use the most virulent human parasite P. falciparum and the rodent parasite P. berghei.