NICHD Cooperative Multicenter Neonatal Research Network

NICHD 多中心新生儿合作研究网络

• 批准号: 7103904
• 负责人: EDWARD F BELL
• 金额: $ 60.8万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-05 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7103904
• 关键词: clinical research; clinical trials; cooperative study; drug screening /evaluation; experimental designs; family genetics; human genetic material tag; human subject; human therapy evaluation; indomethacin; low birth weight infant human; neonatal intensive care; newborn human (0-6 weeks); patent ductus arteriosus; patient oriented research; perinatal; pharmacogenetics; premature infant human; therapy adverse effect; tissue resource /registry

DESCRIPTION (provided by applicant): The Division of Neonatology of the University of Iowa Carver College of Medicine submits this application to become a participating center in the NICHD Cooperative Multicenter Neonatal Research Network (RFAHD-04-010). Our NICU admits between 750 and 800 infants per year, including 350 to 500 inborn infants. The number of admissions has been increasing in the past 3 years, and in fiscal year 2004, we had 808 admissions, including 447 inborn infants. The University of Iowa, Division of Neonatology offers four special strengths to the Network. 1. Our clinical excellence with outcomes among the best in the world. Our standardized mortality ratio for very-low-birth-weight infants is perennially among the lowest (best) 15% in the Vermont Oxford Network. 2. Our strong tradition and track record of important contributions in clinical research in neonates and infants. We have a robust infrastructure for the conduct and support of clinical research and a strong track record of productivity. 3. Our capabilities in the area of genetics and our existing Iowa Perinatal Research DNA Bank. Founded in 1999, this bank contains nearly 3000 DNA samples and corresponding epidemiological data. These samples and data are being used in research examining the genetic factors that influence the occurrence and evolution of disease. Our DNA bank was one of the first examples of a comprehensive attempt to collect DNA from all infants born in a hospital. We believe this innovative resource has tremendous potential for unraveling the basis of many health problems faced in infancy, many with lifelong implications. 4. As the only academic medical center in a largely rural state with an economy based in agriculture, we represent a population that is currently not well represented in the NICHD Network. Moreover, lowans have an unusually sophisticated appreciation for the importance of maternal and child health, derived from their economic and personal interest in animal husbandry, lowans also have a sophisticated appreciation for the power and importance of genetics, derived from their agricultural interests. The applicant investigators and institution are firmly committed to the concept of multicenter clinical trials as the most powerful tool for evaluating new therapies, and we will fully subscribe to the Network's vision.

描述（由申请人提供）：爱荷华大学卡弗医学院新生儿学部提交此申请，希望成为NICHD合作多中心新生儿研究网络（RFAHD-04-010）的参与中心。我们的新生儿重症监护室每年接收750至800名婴儿，其中包括350至500名新生儿。在过去的三年里，入学人数一直在增加，在2004财政年度，我们有808名入学人数，其中包括447名新生儿。爱荷华大学新生儿科为该网络提供了四个特殊优势。我们的临床效果在世界上名列前茅。我们非常低出生体重婴儿的标准化死亡率在佛蒙特牛津网络中一直处于最低（最好）的15%之列。我们在新生儿和婴儿临床研究方面的强大传统和重要贡献的记录。我们拥有开展和支持临床研究的强大基础设施以及良好的生产力记录。3. 我们在遗传学领域的能力和我们现有的爱荷华围产期研究DNA银行。该银行成立于1999年，拥有近3000份DNA样本和相应的流行病学数据。这些样本和数据正在用于研究影响疾病发生和演变的遗传因素。我们的DNA银行是第一个全面尝试从医院出生的所有婴儿收集DNA的例子之一。我们相信，这一创新资源具有巨大的潜力，可以解开婴儿时期面临的许多健康问题的基础，其中许多问题会影响一生。4. 作为一个主要以农业为经济基础的农村国家唯一的学术医疗中心，我们代表的人口目前在NICHD网络中没有得到很好的代表。此外，由于他们对畜牧业的经济和个人兴趣，lowans对孕产妇和儿童健康的重要性有着不同寻常的深刻认识，lowans也对遗传学的力量和重要性有着深刻的认识，这源于他们对农业的兴趣。申请研究人员和机构坚定地致力于将多中心临床试验作为评估新疗法最有力的工具的概念，我们将完全赞同网络的愿景。