WANPRC MACACA NEMESTRINA SPF BREEDING COLONY: AIDS: ANIMAL MODEL

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。描述（由申请人提供）：非人灵长类（NHP）物种已被证明是艾滋病研究在几个领域，包括疫苗开发，治疗剂的发现，和发病机制的宝贵资源。不幸的是，目前存在着猕猴的严重短缺，特别是对M。确定遗传和病原体状态的混血儿。为了满足艾滋病相关研究的需要，必须利用其他种类的猕猴。分枝nemestrina是NHP AIDS研究的一个很好的替代猕猴物种。该物种已在许多研究中心广泛使用，但特别是，它是在WaNPRC使用最频繁的猕猴物种。目前在该物种中存在利用大量灵长类慢病毒和其他感染因子的定义明确的模型。一个小的M.确定病原体（SPF）和遗传状态的nemestrina目前可在WaNPRC用于艾滋病相关研究。本申请寻求扩大该SPF M的尺寸。Nemestrina繁殖群体，以提供适当的NHP的长期可用性显着增加。此外，这一申请试图扩大WaNPRC拥有的一个类似殖民地，但位于印度尼西亚。野生动物的获取在该原产国不受限制，本申请旨在利用这一点快速扩大现有的SPF M。nemestrina殖民地繁殖SPF后代，将被转移到美国。这一方案结构将利用现有的WaNPRC资源，大幅增加M。nemestrina可用于艾滋病研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. DESCRIPTION (Provided by applicant): Nonhuman primate (NHP) species have proven to be invaluable resources for AIDS research in several fields, including vaccine development, therapeutic agent discovery, and pathogenesis. Unfortunately, a significant shortage of macaques currently exists, particularly for the M. mulatta of defined genetic and pathogen status. To meet the needs of AIDS-related research, other species of macaque must be utilized. The M. nemestrina is an excellent alternative macaque species for NHP AIDS studies. This species has been used extensively at a number of research centers, but in particular, it is the most heavily used species of macaque utilized at the WaNPRC. Well-defined models currently exist in this species utilizing a large number of primate lentiviruses and other infectious agents. A small colony of M. nemestrina of defined pathogen (SPF) and genetic status is currently available at the WaNPRC for AIDS-related studies. This application seeks to expand the size of this SPF M. nemestrina breeding colony to provide a significant increase in the long-term availability of appropriate NHPs. In addition, this application seeks to expand a similar colony owned by the WaNPRC, but located in Indonesia. Access to feral animals is not limited in this country of origin and this application seeks to take advantage of this to quickly expand the existing SPF M. nemestrina colony to breed SPF offspring that will be transferred to the United States. This programmatic structure will take advantage of existing WaNPRC resources to provide a significant increase in the number of M. nemestrina available for AIDS research.