WANPRC MACACA NEMESTRINA SPF BREEDING COLONY: AIDS: ANIMAL MODEL

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。描述(由申请人提供)：非人灵长类(NHP)物种已被证明是艾滋病研究的宝贵资源，包括疫苗开发、治疗剂发现和发病机制。不幸的是，目前猕猴数量严重不足，特别是具有明确遗传和病原体状态的短尾猴。为了满足艾滋病相关研究的需要，必须利用其他物种的猕猴。奈米斯特里纳猕猴是NHP艾滋病研究的绝佳替代物种。这一物种在许多研究中心被广泛使用，但特别是，它是WaNPRC使用的最频繁使用的猕猴物种。目前在该物种中存在定义明确的模型，利用大量的灵长类慢病毒和其他感染源。目前，WaNPRC提供了一小群具有明确病原体(SPF)和遗传状态的致病支原体，用于与艾滋病相关的研究。这项应用寻求扩大SPF新月形藻繁殖群体的规模，以显著增加适当NHP的长期可获得性。此外，这项申请寻求扩大一个类似的殖民地，由WaNPRC拥有，但位于印度尼西亚。在这个原产国，接触野生动物并不受限制，这项申请寻求利用这一点，迅速扩大现有的SPF结线虫种群，以繁殖将被转移到美国的SPF后代。这一方案结构将利用世界艾滋病研究中心现有的资源，显著增加可用于艾滋病研究的奈米斯特氏分枝杆菌的数量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. DESCRIPTION (Provided by applicant): Nonhuman primate (NHP) species have proven to be invaluable resources for AIDS research in several fields, including vaccine development, therapeutic agent discovery, and pathogenesis. Unfortunately, a significant shortage of macaques currently exists, particularly for the M. mulatta of defined genetic and pathogen status. To meet the needs of AIDS-related research, other species of macaque must be utilized. The M. nemestrina is an excellent alternative macaque species for NHP AIDS studies. This species has been used extensively at a number of research centers, but in particular, it is the most heavily used species of macaque utilized at the WaNPRC. Well-defined models currently exist in this species utilizing a large number of primate lentiviruses and other infectious agents. A small colony of M. nemestrina of defined pathogen (SPF) and genetic status is currently available at the WaNPRC for AIDS-related studies. This application seeks to expand the size of this SPF M. nemestrina breeding colony to provide a significant increase in the long-term availability of appropriate NHPs. In addition, this application seeks to expand a similar colony owned by the WaNPRC, but located in Indonesia. Access to feral animals is not limited in this country of origin and this application seeks to take advantage of this to quickly expand the existing SPF M. nemestrina colony to breed SPF offspring that will be transferred to the United States. This programmatic structure will take advantage of existing WaNPRC resources to provide a significant increase in the number of M. nemestrina available for AIDS research.