WANPRC MACACA NEMESTRINA SPF BREEDING COLONY: AIDS: ANIMAL MODEL

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。描述（由申请人提供）：非人类灵长类动物（NHP）物种已被证明是艾滋病研究的几个领域的宝贵资源，包括疫苗开发，治疗剂发现和发病机制。不幸的是，目前存在严重的猕猴短缺，特别是具有明确遗传和病原体状态的猕猴。为了满足艾滋病相关研究的需要，必须利用其他种类的猕猴。nemestrina猕猴是NHP艾滋病研究的一个极好的替代猕猴物种。该物种已在许多研究中心被广泛使用，但它是WaNPRC使用最多的猕猴物种。目前在该物种中存在定义良好的模型，利用大量灵长类慢病毒和其他传染因子。在WaNPRC目前有一个小的限定病原体（SPF）和遗传状态的nemestrina菌落用于艾滋病相关研究。本应用程序旨在扩大SPF M. nemestrina繁殖群体的规模，以提供适当NHPs的长期可用性的显着增加。此外，这个应用程序寻求扩大WaNPRC拥有的类似殖民地，但位于印度尼西亚。在这个原产国，对野生动物的接触不受限制，这项申请旨在利用这一点，迅速扩大现有的SPF M. nemestrina种群，繁殖SPF后代，这些后代将被转移到美国。这一规划结构将利用现有的WaNPRC资源，显著增加可用于艾滋病研究的nemestrina病毒的数量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. DESCRIPTION (Provided by applicant): Nonhuman primate (NHP) species have proven to be invaluable resources for AIDS research in several fields, including vaccine development, therapeutic agent discovery, and pathogenesis. Unfortunately, a significant shortage of macaques currently exists, particularly for the M. mulatta of defined genetic and pathogen status. To meet the needs of AIDS-related research, other species of macaque must be utilized. The M. nemestrina is an excellent alternative macaque species for NHP AIDS studies. This species has been used extensively at a number of research centers, but in particular, it is the most heavily used species of macaque utilized at the WaNPRC. Well-defined models currently exist in this species utilizing a large number of primate lentiviruses and other infectious agents. A small colony of M. nemestrina of defined pathogen (SPF) and genetic status is currently available at the WaNPRC for AIDS-related studies. This application seeks to expand the size of this SPF M. nemestrina breeding colony to provide a significant increase in the long-term availability of appropriate NHPs. In addition, this application seeks to expand a similar colony owned by the WaNPRC, but located in Indonesia. Access to feral animals is not limited in this country of origin and this application seeks to take advantage of this to quickly expand the existing SPF M. nemestrina colony to breed SPF offspring that will be transferred to the United States. This programmatic structure will take advantage of existing WaNPRC resources to provide a significant increase in the number of M. nemestrina available for AIDS research.