Beta Imager 2000Z Digital Imaging System

Beta Imager 2000Z 数字成像系统

• 批准号: 6874068
• 负责人: Jason S. Lewis
• 金额: $ 24.9万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6874068
• 关键词: biomedical equipment purchase; charge coupled device camera; digital imaging; drug screening /evaluation; scintillation cameras; tomography

DESCRIPTION (provided by applicant): Small animal imaging has become a very powerful tool for both drug development and in the understanding of diseases in animal models. The use of small animal imaging technologies has expedited the translation of basic science research to the clinic. Washington University School of Medicine (WUSM) is a world leader in the concept and design of new radiopharmaceuticals and drugs. Aiding in the screening of new radiopharmaceutieals are two state-of-the-art microPET tomographs. Conventionally, autoradiography has been used as a gold standard for determining the exact localization of tracer within small organ structures. This has become more difficult for new radiopharmaceuticals labeled with positron-emitting isotopes with short half lives such as C-11. An instrument with comparable resolution to autoradiography, but high sensitivity, will be extremely beneficial to augment microPET imaging, therefore streamlining the design and implementation of new radiopharmaceuticals. The Biospace a Imager offers the adequate resolution to answer these requirements. The system uses a new Parallel Plate Avalanche Detector that employs scintillation techniques and a CCD camera to more accurately locate the site of each decay event. In the a Imager, a gaseous mixture of argon and triethylamine vapor acts as the counting gas while crossed-wire grids operate at 3-4 kV, twice the usual proportional counting voltage. At each decay event, the electron avalanche produces gaseous scintillation; for argon, approximately 35 photons are produced per keV of beta particle energy with the output centered at 280 nm. The photons form a spot that is then viewed by the camera. Not only is that event recorded, but also the particle origin on the monitor in real-time. The Biospace Beta Imager offers a field of view/sample size of 200 mm x 250 mm suitable for whole mouse imaging and 4 levels of zoom. It has exceptional detection thresholds (e.g., 3H 0.007 cpm/mm2; 14C, 35S, 33p 0.01 cpm/mm2; 32p 0.1 cpm/mm2) and spatial resolution (Full-Width at Half Maximum as low as 60 fm for the smallest detectable feature) and a pixel resolution to 10 fm. The efficiency (the ratio of detected particles to number of particles emerging from sample) can be as high as 90% with a linearity of better than 2% over a dynamic range of 104. The instrument is supported by beta VISION +TM software for image analysis with the option for dual-isotope analysis. This proposal from WUSM, is to request funds for a Biospace a Imager to aid in the design and application of drugs and radiopharmaceuticals for the betterment of researchers from a broad range of disciplines, including ontology, neurology, chemistry and pulmonary medicine.

描述（由申请人提供）： 小动物成像已成为药物开发和对动物模型中疾病的理解的非常强大的工具。小型动物成像技术的使用加速了将基础科学研究转化为诊所。华盛顿大学医学院（WUSM）是新的放射药物和药物概念和设计的世界领导者。有助于筛选新的放射性药物，是两个最先进的微型网状扫描仪。通常，放射自显影已被用作黄金标准，用于确定示踪剂在小型器官结构中的确切定位。对于带有正电子发射同位素标记的新​​的放射性药物，诸如C-11的寿命短，这变得更加困难。具有与放射自显影相当但高灵敏度的类似分辨率的仪器将对增强微型tem成像非常有益，因此可以简化新的放射性药物的设计和实施。成像师的生物宽面积提供了足够的解决方案来回答这些要求。该系统使用新的平行板雪崩检测器，该检测器采用闪烁技术和CCD摄像头更准确地定位了每个衰减事件的位置。在A成像仪中，氩气和三乙胺蒸气的气态混合物充当计数气体，而交叉线网则以3-4 kV的作用，是通常的比例计数电压的两倍。在每个衰减事件中，电子雪崩会产生气态闪烁。对于氩气，每keV的β粒子能量约为35个光子，其输出为280 nm。光子形成一个点，然后由相机查看。不仅记录了该事件，而且还记录了监视器上的粒子来源。 Biospace Beta成像器提供的视野/样本量为200 mm x 250 mm，适用于整个鼠标成像和4个缩放水平。它具有出色的检测阈值（例如3H 0.007 cpm/mm2; 14c，35s，33p 0.01 cpm/mm2; 32p 0.1 cpm/mm2）和空间分辨率（全宽度（全尺寸）（全半宽度最高较低，最大为60 fm的最高可检测功能为60 fm）和最小的功能）和Pixel nesoloution for pixel nesourte to Pixel nesourte to Pixel nesourte to Pixel nosolutions and pixel and pixel and pixel nosloute to pixel and。效率（检测到的颗粒与样品中出现的颗粒数的比率）可以高达90％，线性在104的动态范围内的线性高于2％。仪器由Beta Vision +TM软件提供图像分析，并提供对双等激素分析的选项。 WUSM的这一提议是为生物范围的成像师索取资金，以帮助设计和应用药物和放射性药物，以改善来自广泛学科的研究人员，包括本体论，神经病学，化学和肺部医学。