PLANNING INTERDISCIPLINARY STUDIES OF DIABETIC HEART: PILOT RESEARCH PROJECTS

规划糖尿病心脏的跨学科研究：试点研究项目

• 批准号: 7171424
• 负责人: DANIEL PATRICK KELLY
• 金额: $ 11.74万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171424
• 关键词: biomarker; cardiovascular disorder; diabetes mellitus; disease /disorder proneness /risk; early diagnosis; experimental designs; health science research; interdisciplinary collaboration; pathologic process; phenotype; training

DESCRIPTION (provided by applicant): The overall goal of this proposal is to establish a planning process to develop novel interdisciplinary strategies to rapidly translate discovery to reduce the burden of diabetic cardiovascular disease, a serious and common medical problem with profound implications for world health. This planning proposal will involve the collective efforts of an interdisciplinary team spanning across 13 departments and 4 colleges at Washington University in St. Louis in partnership with a national population outcomes group. The planning process will be conducted within the framework of the following three elements: Fundamental Discovery to address the pathobiology of diabetic heart and vascular disease; a Technological Platform to support interdisciplinary research activities; and Translational Studies and Clinical Implementation to move discovery to new paradigms in patient care. The process will begin as an open, university-wide dialogue to address existing barriers to transforming "multidisciplinary" research to true "interdisciplinary" units. Planning groups linked to Fundamental Discovery and Translation Pathways will be formed. The Planning groups will come together to develop research strategies that integrate disciplines, establish novel cross-disciplinary training approaches, and evaluate and validate candidate biomarkers aimed at the early detection and risk stratification of myocardial and vascular disease in the diabetic. Rigorous phenotyping strategies will be devised for studies in small groups of humans to assess the potential utility of molecular, biochemical, and imaging markers to detect disease. Plans to validate biomarkers will be developed with population outcomes collaborators. An important long-term goal of the planning process is to outline strategies aimed at the development of a panel of biomarkers that will revolutionize the way we care for diabetic patients through early detection of myocardial and vascular disease, risk stratification, and therapeutic decision-making. It is envisioned that principles established by the fundamental paradigm shift developed through our efforts will be applicable to other complex disease states in the future.

描述（由申请人提供）： 该提案的总体目标是建立一个规划过程，以制定新的跨学科战略，快速转化发现，以减轻糖尿病心血管疾病的负担，这是一个严重而常见的医学问题，对世界卫生具有深远的影响。这项规划提案将涉及圣路易斯华盛顿大学13个系和4个学院的一个跨学科小组与一个国家人口成果小组合作作出集体努力。规划过程将在以下三个要素的框架内进行：基础发现，以解决糖尿病心脏和血管疾病的病理生物学;技术平台，以支持跨学科研究活动;转化研究和临床实施，以将发现转移到患者护理的新范式。这一进程将开始作为一个开放的，全大学范围的对话，以解决现有的障碍，将“多学科”研究转化为真正的“跨学科”单位。将成立与基础发现和翻译途径相关的规划小组。规划小组将共同制定整合学科的研究策略，建立新的跨学科培训方法，并评估和验证候选生物标志物，旨在早期检测和糖尿病心肌和血管疾病的风险分层。将设计严格的表型分析策略，用于在小人群中进行的研究，以评估分子、生物化学和成像标记物检测疾病的潜在效用。将与人口结局合作者一起制定验证生物标志物的计划。规划过程的一个重要长期目标是概述旨在开发一组生物标志物的策略，这些生物标志物将通过早期检测心肌和血管疾病，风险分层和治疗决策来彻底改变我们护理糖尿病患者的方式。据设想，通过我们的努力开发的基本范式转变所建立的原则将适用于未来的其他复杂疾病状态。