PLANNING INTERDISCIPLINARY STUDIES OF DIABETIC HEART: TRANSLATIONAL & CLINICAL

描述(由申请人提供)： 这项提议的总体目标是建立一个规划程序，以开发新的跨学科战略，迅速将发现转化为减少糖尿病心血管疾病的负担，这是一个严重而常见的医疗问题，对世界健康具有深远影响。这项规划提案将涉及圣路易斯华盛顿大学13个系和4所学院的跨学科团队与一个国家人口成果小组的共同努力。规划过程将在以下三个要素的框架内进行：基础发现，以解决糖尿病心脏和血管疾病的病理生物学；一个支持跨学科研究活动的技术平台；以及转化研究和临床实施，将发现转移到患者护理的新范式。这一进程将作为一个开放的、全大学范围的对话开始，以解决将“多学科”研究转变为真正的“跨学科”单位的现有障碍。将成立与基本发现和翻译路径相关的规划小组。规划小组将共同开发整合各学科的研究战略，建立新的跨学科培训方法，并评估和验证旨在糖尿病患者心肌和血管疾病的早期发现和风险分层的候选生物标记物。将制定严格的表型策略，用于在人类小群体中进行研究，以评估分子、生化和成像标记物检测疾病的潜在效用。将与人口结果合作者一起制定验证生物标记物的计划。规划过程的一个重要的长期目标是概述旨在开发一组生物标志物的战略，这些生物标志物将通过早期发现心肌和血管疾病、风险分层和治疗决策来彻底改变我们照顾糖尿病患者的方式。可以预见，通过我们的努力形成的根本性范式转变所确立的原则将在未来适用于其他复杂的疾病状态。

DESCRIPTION (provided by applicant): The overall goal of this proposal is to establish a planning process to develop novel interdisciplinary strategies to rapidly translate discovery to reduce the burden of diabetic cardiovascular disease, a serious and common medical problem with profound implications for world health. This planning proposal will involve the collective efforts of an interdisciplinary team spanning across 13 departments and 4 colleges at Washington University in St. Louis in partnership with a national population outcomes group. The planning process will be conducted within the framework of the following three elements: Fundamental Discovery to address the pathobiology of diabetic heart and vascular disease; a Technological Platform to support interdisciplinary research activities; and Translational Studies and Clinical Implementation to move discovery to new paradigms in patient care. The process will begin as an open, university-wide dialogue to address existing barriers to transforming "multidisciplinary" research to true "interdisciplinary" units. Planning groups linked to Fundamental Discovery and Translation Pathways will be formed. The Planning groups will come together to develop research strategies that integrate disciplines, establish novel cross-disciplinary training approaches, and evaluate and validate candidate biomarkers aimed at the early detection and risk stratification of myocardial and vascular disease in the diabetic. Rigorous phenotyping strategies will be devised for studies in small groups of humans to assess the potential utility of molecular, biochemical, and imaging markers to detect disease. Plans to validate biomarkers will be developed with population outcomes collaborators. An important long-term goal of the planning process is to outline strategies aimed at the development of a panel of biomarkers that will revolutionize the way we care for diabetic patients through early detection of myocardial and vascular disease, risk stratification, and therapeutic decision-making. It is envisioned that principles established by the fundamental paradigm shift developed through our efforts will be applicable to other complex disease states in the future.