COBRE: OK MED RES FOUND: P4: IN VIVO FUNCTIONS OF GALACTOSYLTRANSFERASE IN MICE

COBRE：OK MED RES Found：P4：小鼠半乳糖基转移酶的体内功能

• 批准号: 7171276
• 负责人: Lijun Xia
• 金额: $ 27.83万
• 依托单位: OKLAHOMA MEDICAL RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171276
• 关键词: clinical research; host organism interaction; immune response; posttranslational modifications

DESCRIPTION (provided by applicant): This proposal for a Center for Biomedical Research Excellence (COBRE) originates from the Oklahoma Medical Research Foundation (OMRF). It includes key collaborations with the adjacent University of Oklahoma Health Sciences Center (OUHSC) in Oklahoma City and with the main campus of the University of Oklahoma (UO), located 20 miles south of Oklahoma City in Norman. The scientific theme is the role of glycosylation in host defense. Virtually all membrane and secreted proteins undergo post-translational modifications, particularly glycosylation. Yet the functions of these extremely diverse modifications remain poorly understood. Oklahoma has developed major strengths in this area. The proposal aims to build on these strengths by interfacing glycobiology with existing and emerging expertise in cardiovascular biology, bioengineering, and immunology. This interdisciplinary approach centers on active participation of productive, senior investigators in mentoring a group of promising junior investigators. New Core facilities will further enhance their research. The success of these junior investigators will enlarge the critical mass of talent in overlapping scientific areas, a synergistic method to expand the biomedical research infrastructure in Oklahoma.

描述（由申请人提供）：