INTERNATIONAL SYMPOSIUM ON COMPUTATIONAL CELL BIOLOGY

描述（由申请人提供）：国家细胞分析和建模资源位于康涅狄格大学健康中心生物医学成像技术中心（CBIT）内，是该中心的主要企业。该资源包含研究活细胞的最先进设备，并开发了一项新技术，即虚拟细胞，用于分析和合成这些知识。虚拟细胞是模拟细胞生物过程的一般框架。它通过将描述个体反应的生化和电生理数据与描述其细胞位置的实验显微图像数据相关联来解决问题。单个过程集成在一个物理和计算基础设施中，该基础设施将容纳任何分子机制。这种计算技术是在一个研究中心内开发的，该研究中心装备齐全，可以对活细胞进行微观研究，这确保了实验和理论相互促进，相互促进。技术开发的研究计划分为两个以理论为中心的项目和三个以实验为主的项目。计算基础设施解决了在透明的物理和数学基础上分层细胞生物学模型的问题，在分布式计算环境中实现数值方法；完善远程访问的用户界面和相关的图像和反应机制数据库。细胞生物学过程的数学和物理分析有三个目标：对无数细胞生物学机制背后的基本物理过程进行广义的数学描述；开发和验证有效的数值方法；以及从实验数据中建立和完善模型的严格方法的发展。钙动力学旨在通过实验和建模方法的系统结合来阐明细胞内钙信号；

DESCRIPTION (as provided by applicant): The National Resource for Cell Analysis and Modeling is housed within, and is the principal venture of, the Center for Biomedical Imaging Technology (CBIT) at the University of Connecticut Health Center. The Resource contains state of the art facilities for studying living cells and has developed a new technology, the Virtual Cell, for analyzing and synthesizing this knowledge. The Virtual Cell is a general framework for modeling cell biological processes. It approaches the problem by associating biochemical and electrophysiological data describing individual reactions with experimental microscopic image data describing their cellular locations. Individual processes are integrated within a physical and computational infrastructure that will accommodate any molecular mechanism. That this computational technology is being developed within a research center fully equipped for microscopic studies of living cells assures that experiment and theory drive each other synergistically. The research plan for the technology development is divided into two projects centered on theory and three that are primarily experimental. Computational Infrastructure addresses the issues of layering the cell biological models on a transparent physical and mathematical foundation, implementing the numerical methods in a distributed computing environment; and refining the remotely accessible user interface and associated database of images and reaction mechanisms. Mathematical and Physical Analysis of Cell Biological Processes has 3 goals: formulation of generalized mathematical descriptions of the elementary physical processes underlying the myriad of cell biological mechanisms; development and validation of efficient numerical methods; and development of rigorous methods for building and refining models from experimental data. Calcium Dynamics aims to elucidate intracellular calcium signaling in cells via a systematic marriage of experiment and modeling approaches;