3D bioprinting nanofibre-reinforced vascular branches

3D生物打印纳米纤维增强血管分支

• 批准号: 2879497
• 金额: --
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2879497
• 关键词: 3D; bioprinting; nanofibre; reinforced; vascular

The lack of vascularisation is the main bottleneck of bioprinting functional organs. This project will develop vascular branches with varying inner diameters by using co-axial extrusion bioprinting. The fabricated hydrogels will be reinforced with electrospun nanofibres. Integrating electrospun nanofibres into hydrogels can synthesise materials with tuneable mechanical properties. Incorporation of nanofibres can be performed by electrospinning on the structure or by mixing electrospun fibres into the hydrogel. The morphology, the mechanical properties of the branches, the long-term cell viability, and the function of the encapsulated cells will be investigated.

缺乏血管化是生物打印功能器官的主要瓶颈。本项目将采用共轴挤压生物打印技术，开发不同内径的血管分支。制备的水凝胶将用静电纺丝纳米纤维增强。将静电纺纳米纤维整合到水凝胶中可以合成具有可调机械性能的材料。纳米纤维的掺入可以通过在结构上进行静电纺丝或通过将静电纺丝纤维混合到水凝胶中来实现。研究人员将对这些分枝的形态、力学性能、细胞的长期生存能力和被包被细胞的功能进行研究。