Basic Research Support for the CCR

基础科学计划（BSP）为NCI提供科学和技术专业知识， 癌症研究中心（CCR）与癌症和其他疾病有关，并开发 先进的工具来加速进步。重点领域包括癌症，逆转录病毒学，基础 生物学，结构生物学，信息学，细胞机制，以及遗传因素， 影响疾病易感性和进展。有12个CCR研究项目得到支持 由BSP：1）基础研究实验室-研究细胞，分子，遗传， 影响疾病进展、诊断和治疗的生化和免疫学机制 2）癌症创新实验室-研究重点是探索基础生物学 与癌症相关的概念和机制; 3）化学生物学实验室-发现新的 影响癌症和艾滋病的小分子、肽、大分子、阵列和材料 诊断和治疗; 4）RNA生物学实验室-使用各种生物体， 研究染色体动力学和调控; 5）HIV动力学和复制计划- 结构生物学、生物化学、病毒学、病毒-宿主相互作用、进化和 体内病毒生物学，以更好地了解逆转录病毒复制的机制; 结构生物学-研究与结构生物学相关的系统和技术， 其应用; 7）分子目标计划-一个跨学科的，协作的， 以团队为导向的方法来识别和验证潜在的癌症相关目标; 8） 小鼠癌症遗传学计划-使用分子小鼠遗传学作为主要工具， 了解哺乳动物发育和疾病的基本过程; 9）泌尿科 肿瘤学分支-肾癌易感基因的发现和表征; 10） 遗传学分支-给定生物样本的分子图谱; 11）疫苗分支-阐明 免疫应答和分子病毒学的基本机制和12）实验 移植和免疫治疗分支-基础，临床前和临床研究， 免疫治疗、免疫重建、T细胞生物学、造血和 造血干细胞移植

The Basic Science Program (BSP) provides scientific and technical expertise to NCI's Center for Cancer Research (CCR) related to cancer and other diseases, and to develop cutting-edge tools to accelerate progress. Areas of focus include cancer, retrovirology, basic biology, structural biology, informatics, cellular mechanisms, and the genetic factors that influence disease susceptibility and progression. There are 12 CCR research programs supported by the BSP: 1) Basic Research Laboratory - research on the cellular, molecular, genetic, biochemical, and immunological mechanisms affecting the progression, diagnosis, and treatment of cancer; 2) Cancer Innovation Laboratory - studies focus on exploring fundamental biological concepts and mechanisms relevant to cancer; 3) Chemical Biology Laboratory - discovery of new small molecules, peptides, macromolecules, arrays and materials that impact cancer and AIDS diagnostics and treatment; 4) RNA Biology Laboratory - uses a variety of organisms to investigate chromosome dynamics and regulation; 5) HIV Dynamics and Replication Program - studies in structural biology, biochemistry, virology, virus-host interaction, evolution, and in vivo virus biology to better understand mechanisms of retroviral replication; 6) Center for Structural Biology - investigates systems and techniques relevant to structural biology and its applications; 7) Molecular Targets Program - an interdisciplinary, collaborative, team-oriented approach to identifying and validating potential cancer-pertinent targets; 8) Mouse Cancer Genetics Program - uses molecular mouse genetics as a primary tool to better understand the fundamental processes underlying mammalian development and disease; 9) Urologic Oncology Branch - discovery and characterization of renal carcinoma susceptibility genes; 10) Genetics Branch - molecular profile of a given biospecimen; 11) Vaccine Branch - elucidate basic mechanisms of immune response and molecular virology and 12) Experimental Transplantation and Immunotherapy Branch - basic, preclinical and clinical investigations in the areas of immunotherapy, immune reconstitution, T cell biology, hematopoiesis, and hematopoietic stem cell transplantation.