Frascati-mediated Iron Metabolism in Erythroblasts
Frascati-mediated Iron Metabolism in Erythroblasts
批准号:
7217636
负责人:
BARRY H PAW
金额:
$25.88万
依托单位国家:
美国
项目类别:
财政年份:
2006
资助国家:
美国
项目状态:
已结题
起止时间:
2006-07-01 至 2011-06-30
中文摘要
本提案的目的是确定相互作用的蛋白质伙伴和生化途径
英文摘要
The objective of this proposal is to identify the interacting protein partners and biochemical pathway of the
frascati mitochondrial metal transporter and their role in erythroid development. The biochemistry and
proteins involved in mitochondrial iron metabolism of developing erythroblasts are poorly understood.
Mutations in the zebrafish frascati gene lead to a profound hypochromic anemia and maturation arrest at the
pro-erythroblast stage. Using a positional cloning strategy, we showed that the frascati encodes a novel
member of the mitochondrial solute carrier family (SLC25). The frascati gene is highly expressed in fetal and
adult hematopoietic tissues of zebrafish and mouse. Erythroblasts generated from frascati-null ES cells
exhibit maturation arrest with severely impaired incorporation of 55Fe into heme. Mouse mutants generated
by targeted disruption of the frascati locus die of severe anemia, thereby confirming its essential role in
mammalian erythroid development. We showed that frascati is the major transporter for delivering iron into
the mitochondria for heme and Fe-S cluster biosynthesis in developing erythroid cells. The goal of this
proposal is to identify the biochemical pathway and interacting protein partners of the frascati transporter to
further our understanding of mitochondrial iron metabolism in developing red cells. The identification of
frascati as an essential mitochondrial iron transporter and its interacting proteins will provide powerful
genetic tools for exploring human disorders of iron metabolism and erythropoiesis. We propose to achieve
these aims by the following two specific aims:
Specific Aim 1: Protein interacting partners of the frascati transporter will be identified and characterized.
Specific Aim 2: A comparative transcriptome analysis of zebrafish embryos and mouse cells deficient for the
frascati transporter will be conducted.
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Frascati-mediated Mitochondrial Metabolism
-
批准号:8205189
-
项目类别:
-
资助金额:$35.68万
-
财政年份:2011
-
负责人:BARRY H PAW
-
依托单位:
Frascati: mitochondrial transporter and erythropoiesis
-
批准号:7566038
-
项目类别:
-
资助金额:$35.16万
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财政年份:2007
-
负责人:BARRY H PAW
-
依托单位:
Frascati: mitochondrial transporter and erythropoiesis
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批准号:7350215
-
项目类别:
-
资助金额:$35.16万
-
财政年份:2007
-
负责人:BARRY H PAW
-
依托单位:
Frascati-mediated Iron Metabolism in Erythroblasts
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批准号:7458644
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项目类别:
-
资助金额:$27.89万
-
财政年份:2007
-
负责人:BARRY H PAW
-
依托单位:
Frascati: mitochondrial transporter and erythropoiesis
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批准号:7211687
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项目类别:
-
资助金额:$35.88万
-
财政年份:2007
-
负责人:BARRY H PAW
-
依托单位:
Frascati: mitochondrial transporter and erythropoiesis
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批准号:8052887
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项目类别:
-
资助金额:$34.46万
-
财政年份:2007
-
负责人:BARRY H PAW
-
依托单位:
GENETIC ANALYSIS--DYSERYTHROPOIETIC ANEMIA IN ZEBRAFISH
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批准号:2679126
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项目类别:
-
资助金额:$10.79万
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财政年份:1998
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负责人:BARRY H PAW
-
依托单位:
GENETIC ANALYSIS--DYSERYTHROPOIETIC ANEMIA IN ZEBRAFISH
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批准号:2905017
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项目类别:
-
资助金额:$12.04万
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财政年份:1998
-
负责人:BARRY H PAW
-
依托单位:
GENETIC ANALYSIS--DYSERYTHROPOIETIC ANEMIA IN ZEBRAFISH
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批准号:6176952
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项目类别:
-
资助金额:$12.04万
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财政年份:1998
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负责人:BARRY H PAW
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依托单位:
Frascati-mediated Iron Metabolism in Erythroblasts
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批准号:8102790
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项目类别:
-
资助金额:$38.18万
-
财政年份:--
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负责人:BARRY H PAW
-
依托单位:
Frascati-mediated Mitochondrial Metabolism
-
批准号:8515498
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项目类别:
-
资助金额:$31.73万
-
财政年份:--
-
负责人:BARRY H PAW
-
依托单位:
Project 5 Frascati-mediated Mitochondrial Metabolism, Barry Paw
-
批准号:9276321
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项目类别:
-
资助金额:$33.62万
-
财政年份:--
-
负责人:BARRY H PAW
-
依托单位:
Frascati-mediated Mitochondrial Metabolism
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批准号:8379736
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项目类别:
-
资助金额:$33.58万
-
财政年份:--
-
负责人:BARRY H PAW
-
依托单位:
Frascati-mediated Iron Metabolism in Erythroblasts
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批准号:7885343
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项目类别:
-
资助金额:$37.05万
-
财政年份:--
-
负责人:BARRY H PAW
-
依托单位:
Frascati-mediated Iron Metabolism in Erythroblasts
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批准号:7652275
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项目类别:
-
资助金额:$35.24万
-
财政年份:--
-
负责人:BARRY H PAW
-
依托单位:
Frascati-mediated Mitochondrial Metabolism
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批准号:8693645
-
项目类别:
-
资助金额:$32.41万
-
财政年份:--
-
负责人:BARRY H PAW
-
依托单位:
Frascati-mediated Mitochondrial Metabolism
-
批准号:8889294
-
项目类别:
-
资助金额:$36.23万
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财政年份:--
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负责人:BARRY H PAW
-
依托单位:
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