Stress, Lead, Iron Deficiency and Neurodevelopment

压力、铅、缺铁和神经发育

• 批准号: 7209568
• 负责人: Robert O Wright
• 金额: $ 47.09万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-01-15 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7209568
• 关键词: Address; Age-Months; Age-Years; American; Anemia; Animals; Archives; Area Under Curve; Biological; Biological Markers; Birth; Blood; British; Chemicals; Child; Child Development; Chronic; Chronic stress; Cities; Cognitive; Cohort Analysis; Cohort Studies; Communities; Complex; Data; Data Analyses; Development; Dietary Iron; Dose; Economics; Effectiveness; Environmental Health; Environmental Risk Factor; Epidemiologic Studies; Epidemiology; Feasibility Studies; Funding; Future; Genes; Genotype; Goals; Hemoglobin; Human; Hydrocortisone; Infant; Infant Development; Institutes; Intake; International; Intervention; Investigation; Iron; Iron deficiency anemia; Joints; Laboratories; Lead; Lead Poisoning; Life; Light; Link; Malnutrition; Measures; Mediating; Medical center; Mexico; Modification; Mothers; Nature; Neurotoxins; Outcome; Participant; Pediatrics; Pilot Projects; Poisoning; Predisposition; Pregnancy; Pregnant Women; Prevention; Prevention strategy; Psychological Stress; Psychosocial Stress; Public Health; Public Health Schools; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Resistance; Salivary; Sample Size; Sampling; Score; Secondary Prevention; Series; Social Environment; Social Sciences; Stress; Testing; Toxic effect; Toxicology; Treatment Protocols; United States National Institutes of Health; Validation; Work; cohort; day; design; developmental psychology; early childhood; gene environment interaction; health disparity; improved; indexing; interest; lead exposure; maternal stress; neurodevelopment; neurotoxicity; nutrition; prenatal; programs; prospective; response; skills; social; social stress; stressor; therapy design

DESCRIPTION (provided by applicant): Social stressors, iron deficiency anemia, and lead exposure are all environmental risk factors for poor neurodevelopment in young children. All three factors are highly prevalent in poor communities, whether in Mexico or the U.S. There are scant human epidemiologic studies on chronic social stress and human neurodevelopment. In addition, previous studies of child development and neurotoxicants have typically analyzed covariate markers of social stress as independent predictors of neurodevelopment; and thus, only considered social factors as potential confounders in their data analysis. There are biological reasons to believe that stress potentiates the toxicity of iron deficiency anemia and lead poisoning. If so, then understanding this relationship may be the key to designing effective public health interventions designed to improve neurodevelopment and may explain the lack of effectiveness of prevention/treatment regimens for lead poisoning and iron deficiency. A prospective cohort study with a large sample size is needed to address the potential multiplicative effects of combined stress/iron deficiency anemia and combined stress/lead exposure in predicting infant development. This resubmission includes new data from a pilot study of stress-lead/stress-anemia interactions in 120 mother infant pairs conducted since the prior application, which demonstrates study feasibility and evidence for the hypothesized interactions. In this application we will measure maternal stress levels, infant iron deficiency anemia and lead exposure in a cohort of mother-infant pairs living in Mexico City and longitudinally measure maternal stress, iron stores, lead exposure, salivary cortisol and neurodevelopment beginning pre-natally and extending 3 years post-partum. This project will determine the independent effect of pre- and post-partum maternal stress in predicting infant development, and the multiplicative joint effects of maternal stress/iron deficiency and maternal stress/lead poisoning in predicting infant development.

描述(申请人提供)：社会压力、缺铁性贫血和铅暴露都是导致幼儿神经发育不良的环境风险因素。这三种因素在贫困社区都非常普遍，无论是在墨西哥还是美国。关于慢性社会压力和人类神经发育的人类流行病学研究很少。此外，以前关于儿童发展和神经毒物的研究通常分析社会压力的共变量标记作为神经发育的独立预测因素；因此，在数据分析中只考虑社会因素作为潜在的混杂因素。有生物学理由认为，压力会加剧缺铁性贫血和铅中毒的毒性。如果是这样的话，了解这种关系可能是设计有效的公共卫生干预措施的关键，旨在改善神经发育，并可能解释铅中毒和缺铁缺乏预防/治疗方案缺乏有效性的原因。需要进行一项大样本量的前瞻性队列研究，以探讨应激/缺铁性贫血和联合应激/铅暴露在预测婴儿发育方面的潜在乘数效应。这份重新提交的报告包括了自上次申请以来对120对母婴进行的关于压力-铅/压力-贫血相互作用的初步研究的新数据，这证明了研究的可行性和假设的相互作用的证据。在这项应用中，我们将在墨西哥城的一对母婴队列中测量母亲压力水平、婴儿缺铁性贫血和铅暴露，并纵向测量母亲压力、铁储存、铅暴露、唾液皮质醇和神经发育，从产前到产后3年。该项目将确定产前和产后母亲应激在预测婴儿发育方面的独立作用，以及母亲应激/缺铁和母亲应激/铅中毒在预测婴儿发育方面的乘性联合影响。