Associations among in utero exposure to metals/metal mixtures,stress/stress mixtures, and internalizing problems in early childhood

Brandon Goldson补充研究的总体目标是利用母项目的 暴露专业知识和措施(金属、压力)，以通过检查来解决研究差距 从产前开始的这些暴露与儿童早期高血压的关系 心理健康风险。该项目还将利用计划中的尿液金属分析，费用为3,000英镑 棱镜回声产前样本可以通过大赢与这一补充汇集在一起 分析建议HHEAR EC0376，以及压力措施和儿童行为检查表 (CBCL)通过全回声队列协议收集，并提供协调指导 由PRO Core调查人员在整个生命阶段检查复杂金属和/或 压力混合物对与焦虑和抑郁问题有关的跨诊断(TD)特征的影响 评估至3-6岁。该提案包括与Echo HHEAR和 Pro核心组件。本附录将支持布兰登·戈德森与 西奈山伊坎医学院的棱镜/回声研究小组 进行和解释以6个月和3年结果数据为重点的分析，并获得 有稿件准备经验。这个机会将扩大他在这一角色中的知识 金属在神经毒性中的作用，特别是它们对早期精神病理学的潜在影响 在很大程度上仍未被探索。他还将更深入地了解 化学品和社会应激源之间的相互作用与健康差距。我们的目标是 有两份第一作者的手稿，其中一份在申请之前提交并出版 医学院毕业后的住院医师计划。这将加强他的 计划申请研究驻院计划，以进一步进行研究培训。

The overall goal of Brandon Goldson’s supplemental research is to leverage the parent project’s exposure expertise and measures (metals, stress) to address a research gap by examining associations between these exposures, starting prenatally, and early childhood antecedents of mental health risk. The project will also leverage planned urinary metals assays for n~3,000 PRISM ECHO prenatal samples which can be pooled with this supplement through Big Win analysis proposal HHEAR EC0376, and stress measures and the Child Behavior Checklist (CBCL) collected through the ECHO-wide cohort protocol with guidance on harmonization across life stage by PRO Core investigators, to examine the influence of complex metal and/or stress mixtures on transdiagnostic (TD) features linked to anxiety and depressive problems assessed up to ages 3-6 years. The proposal includes collaborations with ECHO HHEAR and PRO Core components. This supplement will support Brandon Goldson to work with the PRISM/ECHO investigator team at the Icahn School of Medicine at Mount Sinai to conduct and interpret analyses focused on both 6-mo and 3-yr outcome data and to gain experience in manuscript preparation. This opportunity will expand his knowledge in the role of metals in neurotoxicity, specifically their potential impact on early psychopathology which remains largely unexplored. He will also gain a greater understanding of the importance of interactions between chemicals and social stressors in relation to health disparities. The goal is to have 2 first-authored manuscripts, with one submitted and published prior to his applications to residency programs following the completion of medical school. This will strengthen his planned applications for research residency programs to further his research training.