Associations among in utero exposure to metals/metal mixtures,stress/stress mixtures, and internalizing problems in early childhood

子宫内接触金属/金属混合物、压力/压力混合物与幼儿期内化问题之间的关联

• 批准号: 10412666
• 负责人: Robert O Wright
• 金额: $ 4.08万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10412666
• 关键词: Address; Age; Anxiety; Biological Assay; Chemicals; Child Behavior Checklist; Collaborations; Data; Goals; Health; Joints; Knowledge; Life; Link; Manuscripts; Measures; Mental Health; Metal exposure; Metals; National Institute of Environmental Health Sciences; Outcome; Policies; Preparation; Protocols documentation; Psychopathology; Publishing; Research; Research Personnel; Research Training; Residencies; Risk; Role; Sampling; Stress; Work; childhood anxiety; cohort; depressive symptoms; early childhood; experience; health disparity; medical schools; metal complex; neurotoxicity; parent project; prenatal; prenatal exposure; programs; social stressor; urinary

The overall goal of Brandon Goldson’s supplemental research is to leverage the parent project’s exposure expertise and measures (metals, stress) to address a research gap by examining associations between these exposures, starting prenatally, and early childhood antecedents of mental health risk. The project will also leverage planned urinary metals assays for n~3,000 PRISM ECHO prenatal samples which can be pooled with this supplement through Big Win analysis proposal HHEAR EC0376, and stress measures and the Child Behavior Checklist (CBCL) collected through the ECHO-wide cohort protocol with guidance on harmonization across life stage by PRO Core investigators, to examine the influence of complex metal and/or stress mixtures on transdiagnostic (TD) features linked to anxiety and depressive problems assessed up to ages 3-6 years. The proposal includes collaborations with ECHO HHEAR and PRO Core components. This supplement will support Brandon Goldson to work with the PRISM/ECHO investigator team at the Icahn School of Medicine at Mount Sinai to conduct and interpret analyses focused on both 6-mo and 3-yr outcome data and to gain experience in manuscript preparation. This opportunity will expand his knowledge in the role of metals in neurotoxicity, specifically their potential impact on early psychopathology which remains largely unexplored. He will also gain a greater understanding of the importance of interactions between chemicals and social stressors in relation to health disparities. The goal is to have 2 first-authored manuscripts, with one submitted and published prior to his applications to residency programs following the completion of medical school. This will strengthen his planned applications for research residency programs to further his research training.

布兰登戈德森补充研究的总体目标是利用母项目的 暴露专门知识和措施（金属，压力），以解决研究差距， 这些接触之间的关联，开始产前，和幼儿的前身， 心理健康风险。该项目还将利用计划中的尿金属测定， PRISM ECHO产前样本可通过Big Win与该补充剂合并 分析提案HHEAR EC 0376，压力测量和儿童行为检查表 （CBCL）通过ECHO范围内的队列方案收集，并提供协调指南 PRO核心研究人员在整个生命阶段进行研究，以检查复杂金属和/或 强调与焦虑和抑郁问题相关的跨诊断（TD）特征的混合物 评估年龄为3-6岁。该提案包括与ECHO HHEAR的合作， PRO核心组件。此补充将支持布兰登戈德森与 西奈山伊坎医学院的PRISM/ECHO调查小组， 对6个月和3年的结局数据进行分析和解释， 有手稿准备的经验。这个机会将扩大他在这个角色中的知识 金属在神经毒性中的作用，特别是它们对早期精神病理学的潜在影响， 大部分尚未开发。他还将更好地了解 化学品与社会压力因素之间的相互作用与健康差距。目标是 有2个第一作者的手稿，其中一个提交并发表之前，他的申请 在医学院毕业后参加住院医师项目。这将加强他的 计划申请研究住院医师项目，以进一步加强他的研究培训。