Associations among in utero exposure to metals/metal mixtures,stress/stress mixtures, and internalizing problems in early childhood

子宫内接触金属/金属混合物、压力/压力混合物与幼儿期内化问题之间的关联

• 批准号: 10412666
• 负责人: Robert O Wright
• 金额: $ 4.08万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10412666
• 关键词: Address; Age; Anxiety; Biological Assay; Chemicals; Child Behavior Checklist; Collaborations; Data; Goals; Health; Joints; Knowledge; Life; Link; Manuscripts; Measures; Mental Health; Metal exposure; Metals; National Institute of Environmental Health Sciences; Outcome; Policies; Preparation; Protocols documentation; Psychopathology; Publishing; Research; Research Personnel; Research Training; Residencies; Risk; Role; Sampling; Stress; Work; childhood anxiety; cohort; depressive symptoms; early childhood; experience; health disparity; medical schools; metal complex; neurotoxicity; parent project; prenatal; prenatal exposure; programs; social stressor; urinary

The overall goal of Brandon Goldson’s supplemental research is to leverage the parent project’s exposure expertise and measures (metals, stress) to address a research gap by examining associations between these exposures, starting prenatally, and early childhood antecedents of mental health risk. The project will also leverage planned urinary metals assays for n~3,000 PRISM ECHO prenatal samples which can be pooled with this supplement through Big Win analysis proposal HHEAR EC0376, and stress measures and the Child Behavior Checklist (CBCL) collected through the ECHO-wide cohort protocol with guidance on harmonization across life stage by PRO Core investigators, to examine the influence of complex metal and/or stress mixtures on transdiagnostic (TD) features linked to anxiety and depressive problems assessed up to ages 3-6 years. The proposal includes collaborations with ECHO HHEAR and PRO Core components. This supplement will support Brandon Goldson to work with the PRISM/ECHO investigator team at the Icahn School of Medicine at Mount Sinai to conduct and interpret analyses focused on both 6-mo and 3-yr outcome data and to gain experience in manuscript preparation. This opportunity will expand his knowledge in the role of metals in neurotoxicity, specifically their potential impact on early psychopathology which remains largely unexplored. He will also gain a greater understanding of the importance of interactions between chemicals and social stressors in relation to health disparities. The goal is to have 2 first-authored manuscripts, with one submitted and published prior to his applications to residency programs following the completion of medical school. This will strengthen his planned applications for research residency programs to further his research training.

布兰登·戈德森（Brandon Goldson）补充研究的总体目标是利用父母项目的 暴露专业知识和措施（金属，压力）通过检查研究差距 这些暴露之间的关联，从产前开始，以及幼儿的前提 心理健康风险。该项目还将利用n〜3,000的计划的泌尿金属测定法 Prism Echo Echo产前样品，可以通过大胜利汇总此补品 分析提案HHEAR EC0376，以及压力指标和儿童行为清单 （CBCL）通过回声范围的队列协议收集，并有协调指导 Pro Core研究人员在整个生命阶段，检查复杂金属和/或 转诊（TD）的应力混合物与焦虑和抑郁问题有关的特征 评估最多3-6岁。该提案包括与Echo Hhear和 Pro Core组件。这种补充剂将支持布兰登·戈德森（Brandon Goldson）与 西奈山伊坎医学院的Prism/Echo调查员团队 进行和解释分析的重点是6-MO和3年结果数据，并获得 手稿准备的经验。这个机会将扩大他对角色的知识 神经毒性中的金属，特别是它们对早期心理病理学的潜在影响 静止大部分出乎意料。他还将对 与健康差异有关的化学物质与社会压力之间的相互作用。目标是 要有2个首次撰写的手稿，其中一本提交并在其申请之前发布 完成医学院后的居住计划。这将加强他的 计划申请研究居住计划，以进一步进一步研究他的研究培训。