ECHO Consortium on Perinatal Programming of Neurodevelopment

ECHO 围产期神经发育规划联盟

基本信息

项目摘要

Environmental interactions with genes, co-occurring environmental factors, sex, and life stage define normal variation and adverse neurodevelopment over the life course. Beginning in utero, the central nervous system (CNS) develops sequentially with network components of distinct functional domains (e.g., attention, memory, etc.) developing at different times. Thus, toxin effects depend both on timing of exposure and dose. The developing fetus and infant are most vulnerable. Moreover, pregnant women and children are not exposed to a single chemical but to complex chemical mixtures. Complex interactions between chemical and non-chemical stressors as well as sex can also influence outcomes. We propose a new ECHO Consortium of 5,000 prenatally enrolled and prospectively followed ethnically diverse mothers and their children to better address these complexities. Our UG3 mission will be to measure environmental exposures across pregnancy and childhood to determine how pro-oxidant environmental factors affect neurodevelopment. We will leverage methodological advances developed by our team including 1) a novel tooth-based biomarker that can objectively ; 2) satellite remote sensing based air pollution models that can reconstruct ; 3) mixtures statistics; and 4) data-driven statistical reconstruct past exposure timing and dose past exposure timing and dose methods to identify vulnerable windows. The Mount Sinai Consortium will also be part of the larger national ECHO synthetic cohort to study the health impacts of chemicals, nutrition, social factors, the biological response to these exposures, and the gene-environment interactions that underlie childhood disease more broadly. We can both meet our UG3 aims and the goals of the ECHO UH3, as our cohorts have extensive biobanking to facilitate expanded exposure assessment and mechanistic studies and our team has the requisite expertise in phenotyping in the four ECHO focus areas, in exposure science, and in cohort management. In this application, we will establish the infrastructure to coordinate, plan, and communicate with the four cohorts that make up our consortium, while performing similar functions within the greater NIH ECHO program, working with the Coordinating Center, the ECHO Data Center, the Pediatric Research Outcomes (PRO) Core, the future Genomics Core, and the CHEAR Exposure Core. Our Consortium will harmonize the databases of our four established cohorts to achieve these goals in tandem with experts in data science from the CHEAR Network Data Center. This proposal links highly experienced environmental health scientists with, statisticians, social epidemiologists, stress researchers, child psychologists, chemists, pediatricians, toxicologists, geneticists, and epigeneticists to build the infrastructure and scientific capacity to create a highly functional, state of the art longitudinal birth cohort consortium that objectively measures human environments that program child health and integrates with the greater NIH ECHO program.
环境与基因的相互作用、共同发生的环境因素、性别和生命阶段定义了正常

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Robert O Wright其他文献

Effect of Iron on Blood Lead Concentration in Iron Deficient, Lead Poisoned Rats † 703
铁对缺铁性铅中毒大鼠血铅浓度的影响 † 703
  • DOI:
    10.1203/00006450-199804001-00724
  • 发表时间:
    1998-04-01
  • 期刊:
  • 影响因子:
    3.100
  • 作者:
    Robert O Wright;Howard Hu;Timothy J Maher;Chitra Amarasiriwardena;Pasarapa Chaiyakul;Alan D Woolf;Michael W Shannon
  • 通讯作者:
    Michael W Shannon
N-ACETYLCYSTEINE REDUCES METHEMOGLOBIN: AN IN VITRO MODEL.† 969
  • DOI:
    10.1203/00006450-199604001-00991
  • 发表时间:
    1996-04-01
  • 期刊:
  • 影响因子:
    3.100
  • 作者:
    Robert O Wright;Barbarajean Magnani;Michael W Shannon;Alan D Woolf
  • 通讯作者:
    Alan D Woolf

Robert O Wright的其他文献

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{{ truncateString('Robert O Wright', 18)}}的其他基金

Mount Sinai HHEAR Network Targeted Lab Hub
西奈山 HHEAR 网络目标实验室中心
  • 批准号:
    10875017
  • 财政年份:
    2023
  • 资助金额:
    $ 863.4万
  • 项目类别:
Stress-Chemical Interactions and Neurobehavior in School Age Children
学龄儿童的应激化学相互作用和神经行为
  • 批准号:
    10337782
  • 财政年份:
    2021
  • 资助金额:
    $ 863.4万
  • 项目类别:
The Programming Research in Obesity, GRowth, Environment and Social Stress (PROGRESS) Cohort
肥胖、生长、环境和社会压力(PROGRESS)队列的规划研究
  • 批准号:
    9761855
  • 财政年份:
    2017
  • 资助金额:
    $ 863.4万
  • 项目类别:
Associations among in utero exposure to metals/metal mixtures,stress/stress mixtures, and internalizing problems in early childhood
子宫内接触金属/金属混合物、压力/压力混合物与幼儿期内化问题之间的关联
  • 批准号:
    10412666
  • 财政年份:
    2016
  • 资助金额:
    $ 863.4万
  • 项目类别:
ECHO Consortium on Perinatal Programming of Neurodevelopment
ECHO 围产期神经发育规划联盟
  • 批准号:
    10675379
  • 财政年份:
    2016
  • 资助金额:
    $ 863.4万
  • 项目类别:
ECHO Consortium on Perinatal Programming of Neurodevelopment
ECHO 围产期神经发育规划联盟
  • 批准号:
    10018530
  • 财政年份:
    2016
  • 资助金额:
    $ 863.4万
  • 项目类别:
ECHO Consortium on Perinatal Programming of Neurodevelopment
ECHO 围产期神经发育规划联盟
  • 批准号:
    10239019
  • 财政年份:
    2016
  • 资助金额:
    $ 863.4万
  • 项目类别:
Mount Sinai CHEAR Network Laboratory Hub
西奈山 CEAR 网络实验室中心
  • 批准号:
    9351604
  • 财政年份:
    2016
  • 资助金额:
    $ 863.4万
  • 项目类别:
ECHO Consortium on Perinatal Programming of Neurodevelopment
ECHO 围产期神经发育规划联盟
  • 批准号:
    10469680
  • 财政年份:
    2016
  • 资助金额:
    $ 863.4万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10660987
  • 财政年份:
    2015
  • 资助金额:
    $ 863.4万
  • 项目类别:

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激素治疗、绝经年龄、既往产次和 APOE 基因型会影响老年人的认知。
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