Imaging physics development

核心B的总体目标是继续提供最先进的成像工具， 通过提高高场功能性MRI的功能分辨率，为了实现这一目标， 提出了一种新的方法，将重点放在新的功能磁共振成像采集的发展 高灵敏度和特异性的方法，并为我们参与的项目提供可靠的服务功能 信号检测 开发组件的目标是设计、实现和验证新的fMRI采集 对功能性信号源有效、灵敏和特异的方法。重点将放在 1)改进了我们最初开发的用于磁化率信号恢复的新采集方法， 计划项目补助金，以确保进一步提高空间保真度和清晰度，2）开发新的收购 技术，确保提高灵敏度和效率，并使用并行高分辨率 成像基础设施，以及3）通过开发新的成像技术来改善功能信号的特异性 战略，重点放在小血管网络密切联系到真正的神经元活动。预计 这些改进的成像工具将使我们参与的神经科学研究人员能够留在 通过提出更复杂的问题，设计更复杂的 功能成像范例和检测更微妙的信号变化。 服务部分的目标是通过无缝接口确保可靠的扫描仪操作 通过参与项目，为日常运营提供强大的支持平台，以及积极的 质量保证。具体而言，核心将与参与项目密切合作，设计量身定制的扫描 协议，为新开发的技术和工具开发在线教学材料，并实施 监测和确保高信噪比、空间保真度和时间稳定性的程序。我们认为 这些高质量的服务将为整个计划项目提供长期的稳定性和可靠性，并确保 成功实施我们的研究计划。

The overall goal of the Core B is to continue to offer state-of-art imaging tools and support for the scientific projects by improving the functional resolution of high field functional MRI. To achieve this goal, a twoproned approach is proposed that will emphasize on both the development of novel fMRI acquisition methods for high sensitivity and specificity and the service to our participating projects for reliable functional signal detection. The objective of the development component is to design, implement and validate new fMRI acquisition methods that are efficient, sensitive and specific to the functional signal source. Emphases will be placed on 1) refining the novel acquisitions methods for susceptibility signal recovery developed during our initial Program Project Grant to ensure further improved spatial fidelity and clarity, 2) developing new acquisition techniques that ensure increased sensitivity and efficiency and are of high resolution using the parallel imaging infrastructure, and 3) improving the specificity of the functional signal by developing novel imaging strategies to focus on the small vessel networks closely tied to the true neuronal activities. It is anticipated that these improved imaging tools will allow our participating neuroscience researchers to remain at the forefront of neuroimaging research by asking more sophisticated questions, designing more complex functional imaging paradigms and detecting more subtle signal changes. The objective of the service component is to ensure reliable scanner operation through a seamless interface with the participating projects, a robust support platform for daily operation, and an aggressive program of quality assurance. Specifically, the core wil work closely with the participating projects to design tailored scan protocols, develop online instructional materials for newly developed techniques and tools, and implement procedures to monitor and ensure high signal-to-noise ratio, spatial fidelity and temporal stability. We believe these quality services will provide long-term stability and reliability to the overall program project and ensure successful execution of our research plans.