Roles of Wnt Receptors (Frizzled) in Lung Cancer

Wnt 受体（卷曲）在肺癌中的作用

• 批准号: 7287407
• 负责人: DAWN T BRAVO
• 金额: $ 4.88万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-05 至 2009-05-04
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7287407
• 关键词: Biological; Cells; Development; Fellowship; Growth; Malignant neoplasm of lung; Malignant neoplasm of prostate; Mediating; Molecular; PC3 cell line; Pathogenesis; Play; Prostate; Proteins; Role; Signal Pathway; Tissues; cancer cell; cell growth; receptor; selective expression; tumorigenesis

DESCRIPTION (provided by applicant): The molecular mechanism by which Wnt signaling pathways regulate the growth of prostate cells has not been elucidated. Particularly, the identities of the receptors (Frizzled) that selectively express in prostate cancer cells are not known. Furthermore, the biological role Frizzleds play in mediating these signaling pathways during prostate cancer development and progression are not understood. Therefore, identification and characterization of the Frizzled proteins that selectively express in prostate cells and regulate the cell growth of prostate cancer will be very important for understanding the pathogenesis and progression of prostate cancer. The major of objective of this proposal is to investigate the expression and function of Frizzled proteins that are selectively expressed in prostate cancer cells in order to fully understand the biological role of the Wnt signaling pathway in the tumorigenesis of prostate cancer. Three specific aims are proposed in this fellowship, which include (1) Identification of the Frizzled proteins that selectively express in prostate cancer cell lines and prostate cancer tissues; (2) Investigate the biological role of Frizzled proteins in prostate cancer cells; (3) Study the biological role of Frizzleds in the pathogenesis of prostate cancer.

描述(申请人提供)：Wnt信号通路调节前列腺细胞生长的分子机制尚未阐明。特别是，在前列腺癌细胞中选择性表达的受体(Frizzled)的身份尚不清楚。此外，Frizzleds在前列腺癌发生和发展过程中调节这些信号通路所起的生物学作用尚不清楚。因此，鉴定和鉴定在前列腺癌细胞中选择性表达并调节细胞生长的Frizzled蛋白质对于了解前列腺癌的发病机制和进展具有重要意义。本研究的主要目的是研究在前列腺癌细胞中选择性表达的Frizzled蛋白的表达和功能，以全面了解Wnt信号通路在前列腺癌发生发展中的生物学作用。这项研究提出了三个具体目标，包括：(1)鉴定在前列腺癌细胞系和前列腺癌组织中选择性表达的Frizzleed蛋白；(2)研究Frizzleed蛋白在前列腺癌细胞中的生物学作用；(3)研究Frizzleds在前列腺癌发病机制中的生物学作用。