Myeloid Cells: Development, Diversity and Distinct Biological Roles

骨髓细胞：发育、多样性和独特的生物学作用

• 批准号: 10609155
• 负责人: TERRY L. SHEPPARD
• 金额: $ 1.4万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-11-01 至 2023-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10609155
• 关键词: Area; Basic Science; Biological; Biological Process; Biology; Cells; Collaborations; Communicable Diseases; Development; Dimensions; Disease; Educational workshop; Fostering; Growth; Knowledge; Malignant Neoplasms; Metabolism; Methodology; Molecular and Cellular Biology; Myelogenous; Myeloid Cells; Neoplasm Metastasis; Outcome; Physiological; Population; Process; Research; Research Personnel; Role; Scientist; Technology; Therapeutic; Time; Training; Utah; Work; cancer therapy; clinical practice; design; frontier; improved; innovation; myeloid cell development; neutrophil; new technology; next generation; posters; programs; symposium; tumor

ABSTRACT Support is requested for a Keystone Symposia conference entitled Myeloid Cells: Development, Diversity and Distinct Biological Roles, organized by Drs. Gwendalyn Randolph, Minsoo Kim, Roxane Tussiwand, and Muzlifah Haniffa. The conference will be held in Snowbird, Utah from March 16-19, 2023. It is becoming more evident that myeloid cells participate critically in a variety of physiological and pathophysiological processes and that targeting myeloid cells, either at selected stages of their development or as they mature, may be successfully harnessed in the treatment of cancers or infectious disease. The application of rapidly evolving omics technologies are aiding in the quest to increase understanding of myeloid cell diversity and the potential of targeting them therapeutically. However, at the same time, fundamental questions about myeloid cell identity and function remain unknown. This Keystone Symposia conference will address these frontiers as it aims to attract speakers and attendees across the full breadth of the field. The conference program will include key talks intended to focus on the application of new technologies in the field, the advances they bring, best-practice application, and potential complications in analysis. Significant focus will also be given to the role of myeloid cells in cancer and metastasis, including the fast-growing area of how neutrophils aid tumor metastasis. Basic science that covers myeloid cell development and function will be interspersed with talks on the role of myeloid cells in disease states. In the last decades, the number of outstanding scientists in the field has grown tremendously, and this conference will showcase this growth through inclusion of many new dimensions in the field.

抽象的 请求支持Keystone研讨会会议标题为“髓样细胞：发展，多样性和多样性” 由Drs组织的不同生物学作用。 Gwendalyn Randolph，Minsoo Kim，Roxane Tussiwand和 Muzlifah Haniffa。会议将于2023年3月16日至19日在犹他州雪鸟举行。 越来越明显的是，髓样细胞在各种生理和 病理生理过程和针对髓样细胞的靶向髓样细胞，要么在其发育的选定阶段或 随着它们的成熟，可能会成功利用癌症或传染病的治疗。这 快速发展的Omics技术的应用有助于提高对髓样的理解 细胞多样性以及对其进行治疗的潜力。但是，同时，基本 有关髓样细胞身份和功能的问题仍然未知。这次Keystone研讨会会议将 解决这些边界，旨在吸引整个领域的扬声器和与会者。这 会议计划将包括旨在关注新技术在现场的应用的关键对话， 他们带来的进步，最佳实践应用以及分析的潜在并发症。重点 还将给予髓样细胞在癌症和转移中的作用，包括如何快速增长的领域 中性粒细胞有助于肿瘤转移。涵盖髓样细胞开发和功能的基础科学将是 散布着关于髓样细胞在疾病状态中的作用的谈话。在过去的几十年中， 该领域的杰出科学家发展巨大，这次会议将展示这一增长 通过在该领域包含许多新的维度。