Myeloid Cells: Development, Diversity and Distinct Biological Roles

骨髓细胞：发育、多样性和独特的生物学作用

• 批准号: 10609155
• 负责人: TERRY L. SHEPPARD
• 金额: $ 1.4万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-11-01 至 2023-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10609155
• 关键词: Area; Basic Science; Biological; Biological Process; Biology; Cells; Collaborations; Communicable Diseases; Development; Dimensions; Disease; Educational workshop; Fostering; Growth; Knowledge; Malignant Neoplasms; Metabolism; Methodology; Molecular and Cellular Biology; Myelogenous; Myeloid Cells; Neoplasm Metastasis; Outcome; Physiological; Population; Process; Research; Research Personnel; Role; Scientist; Technology; Therapeutic; Time; Training; Utah; Work; cancer therapy; clinical practice; design; frontier; improved; innovation; myeloid cell development; neutrophil; new technology; next generation; posters; programs; symposium; tumor

ABSTRACT Support is requested for a Keystone Symposia conference entitled Myeloid Cells: Development, Diversity and Distinct Biological Roles, organized by Drs. Gwendalyn Randolph, Minsoo Kim, Roxane Tussiwand, and Muzlifah Haniffa. The conference will be held in Snowbird, Utah from March 16-19, 2023. It is becoming more evident that myeloid cells participate critically in a variety of physiological and pathophysiological processes and that targeting myeloid cells, either at selected stages of their development or as they mature, may be successfully harnessed in the treatment of cancers or infectious disease. The application of rapidly evolving omics technologies are aiding in the quest to increase understanding of myeloid cell diversity and the potential of targeting them therapeutically. However, at the same time, fundamental questions about myeloid cell identity and function remain unknown. This Keystone Symposia conference will address these frontiers as it aims to attract speakers and attendees across the full breadth of the field. The conference program will include key talks intended to focus on the application of new technologies in the field, the advances they bring, best-practice application, and potential complications in analysis. Significant focus will also be given to the role of myeloid cells in cancer and metastasis, including the fast-growing area of how neutrophils aid tumor metastasis. Basic science that covers myeloid cell development and function will be interspersed with talks on the role of myeloid cells in disease states. In the last decades, the number of outstanding scientists in the field has grown tremendously, and this conference will showcase this growth through inclusion of many new dimensions in the field.

摘要 请求为题为“骨髓细胞：发展、多样性和 独特的生物作用，由Gwendalyn兰多夫博士，Minsoo Kim，Roxane Tussiwand和 穆兹利法·哈尼法会议将于2023年3月16日至19日在犹他州雪鸟举行。 越来越明显的是，骨髓细胞在多种生理和病理过程中起着关键作用。 病理生理过程和靶向髓样细胞，无论是在其发展的选定阶段， 随着它们的成熟，可能会成功地用于治疗癌症或传染病。的 快速发展的组学技术的应用有助于提高对骨髓细胞的理解， 细胞多样性和治疗靶向它们的潜力。与此同时，基本 关于骨髓细胞的身份和功能的问题仍然是未知的。本次Keystone研讨会将 解决这些前沿问题，因为它旨在吸引整个领域的演讲者和与会者。的 会议计划将包括旨在关注该领域新技术应用的关键会谈， 它们带来的进步、最佳实践应用以及分析中的潜在复杂性。重点突出 还将给予髓细胞在癌症和转移中的作用，包括如何快速增长的领域， 嗜中性粒细胞有助于肿瘤转移。涵盖骨髓细胞发育和功能的基础科学将是 穿插着关于骨髓细胞在疾病状态中的作用的演讲。在过去的几十年里， 该领域的杰出科学家有了巨大的增长，这次会议将展示这种增长 通过在该领域中纳入许多新的方面。