Patient-Oriented Models for Urinary Function in Women

描述(由申请人提供)： 此应用程序申请资金用于两个目的： 1)职业发展：申请人计划在密歇根大学安娜堡分校完成既定的临床研究硕士学位课程。职业目标包括短期目标和长期目标。短期目标包括硕士学习计划，在以患者为中心的研究项目期间监督指导对象，以及完善协作的多学科团队。长期目标包括在临床研究中发挥领导作用，开发中心拨款申请的计划项目，并可能领导临床试验网络。 2)研究计划： -使用同心针EMG(带有定量运动单元分析)和电流知觉测试从女性尿路获取高质量的神经肌肉信号，以验证以下情况下的尿道括约肌神经肌肉功能没有差异的无效假设： I.按种族划分的妇女(高加索人与非裔美国人)， 二、女性大小便失禁状况(大小便失禁与大小便失禁) 三、按产次分列的大陆妇女(经产妇与未产妇)。 -与计算机科学家合作，将这些信号输入到图形计算机模型中，以准确反映我们对尿路功能的临床理解 -将尿路和膀胱数据合并到同一模型中，并为尿路和膀胱相互作用创造“规则”。 B.模拟尿液储存在健康和疾病中的作用 C.模拟健康和疾病中的尿液排空

DESCRIPTION (provided by applicant): This application request funds for two purposes: 1) Career development: the applicant plans to complete an established master's degree program in clinical research at the University of Michigan, Ann Arbor. The career goals include short and long-term goals. Short-term goals include the master's program of study, oversight of mentee during a patient-oriented research project and refinement of a collaborative, multidisciplinary team. The long term goals include assuming a leadership role in clinical research, developing Program Project of Center grant applications, and possibly leading clinical trials network. 2) Research Plan: -To acquire high-quality neuromuscular signals from the female urethra using concentric needle EMG (with quantitative motor unit analysis) and current perception testing in order to test the null hypotheses that there are no differences in urethral sphincter neuromuscular function in: i. Women by race (Caucasian vs. African American), ii. Women by continence status (continent vs. incontinent) iii. Continent women by parity (parous vs. nulliparous). -To collaborate with computer scientists to import these signals into a graphic computer model which accurately reflects our clinical understanding of urethral function -To combine urethral and bladder data into the same model and create "rules" for urethral and bladder interaction. b. To model urinary storage in health and disease c. To model urinary emptying in health and diseas