Patient-Oriented Models for Urinary Function in Women

描述（由申请人提供）： 本申请要求资金用于两个目的： 1)职业发展：申请人计划在密歇根大学安阿伯完成临床研究的硕士学位课程。职业目标包括短期和长期目标。短期目标包括研究硕士课程，在以患者为导向的研究项目期间监督学员，以及改进协作，多学科团队。长期目标包括在临床研究中发挥领导作用，开发中心资助申请的计划项目，并可能领导临床试验网络。 2)研究计划： - 使用同心针EMG（具有定量运动单位分析）和电流感知测试从女性尿道获取高质量的神经肌肉信号，以测试以下方面的尿道括约肌神经肌肉功能没有差异的零假设： I.按种族分列的妇女（高加索人与非裔美国人）， 二.按大小便失禁状况分列的妇女（失禁与失禁） 三.按产次分列的大陆妇女（经产与未经产）。 - 与计算机科学家合作，将这些信号导入图形计算机模型，准确反映我们对尿道功能的临床理解 - 将联合收割机尿道和膀胱数据组合到同一模型中，并创建尿道和膀胱相互作用的“规则”。 B.模拟健康和疾病状态下的尿潴留 C.建立健康和疾病状态下的尿排空模型

DESCRIPTION (provided by applicant): This application request funds for two purposes: 1) Career development: the applicant plans to complete an established master's degree program in clinical research at the University of Michigan, Ann Arbor. The career goals include short and long-term goals. Short-term goals include the master's program of study, oversight of mentee during a patient-oriented research project and refinement of a collaborative, multidisciplinary team. The long term goals include assuming a leadership role in clinical research, developing Program Project of Center grant applications, and possibly leading clinical trials network. 2) Research Plan: -To acquire high-quality neuromuscular signals from the female urethra using concentric needle EMG (with quantitative motor unit analysis) and current perception testing in order to test the null hypotheses that there are no differences in urethral sphincter neuromuscular function in: i. Women by race (Caucasian vs. African American), ii. Women by continence status (continent vs. incontinent) iii. Continent women by parity (parous vs. nulliparous). -To collaborate with computer scientists to import these signals into a graphic computer model which accurately reflects our clinical understanding of urethral function -To combine urethral and bladder data into the same model and create "rules" for urethral and bladder interaction. b. To model urinary storage in health and disease c. To model urinary emptying in health and diseas